NS 660 Exam 1 Questions With Precisely Matched
Solutions
What medication is most associated with increased prolactin Correct
Answer - Risperidal
Which medication is most associated with weight gain Correct Answer -
olanzapine
Second Generation is mainly associated with which side effects? Correct
Answer - Weight gain, hypercholesterolemia, altered glucose tolerance
insulin secretion
First Generation is mainly associated with which side effects? Correct
Answer - TD, EPS
Why is olanzapine associated with weight gain? Correct Answer - High
affinity for 2c receptors
What are the rating scales used to evaluate abnormal movements associated
with psychotropic medication? Correct Answer - SMARTS , AIMS,
PANAS- self report questionnaire, SAGE,
PHQ-depression, COWS-Opioid withdrawl
What is the black box warning of Clozapine Correct Answer -
Agranulocytosis
What is the most common side effect of clozapine Correct Answer -
sedation
What labs need to be done before starting clients on antipsychotic
medications? Correct Answer - fasting lipid panel, fasting glucose,
weight, bp
When someone with schizophrenia is on an atypical antipsychotic with
complaints of increased fatigue, which antipsychotic would you switch to?
Correct Answer - Abilify
, Patient has been on an atypical antipsychotic for 6weeks with unchanged
weight. Do you think that weight would be a good predictor of fasting
triglycerides Correct Answer - no
What is the pathway responsible for regulation of dopamine in the
hypothalamus Correct Answer - mesolimbic pathway
What antidepressant should be avoided for a patient on clozapine? Correct
Answer - Fluvox, paroxetine, sertraline (in large doses)
If a patient is experiencing breast milk secretion while receiving a med that
may stimulate breast secretions which medication could be switched to that
does not have increased prolactin as a side effect? Correct Answer -
Seroquel or zyprexa
What is the pharmacological explanation of the resolution of breast secretion
Correct Answer - decreased dopamine- increased prolactin
Increased serotonin- increased prolactin
Patient gains 25lbs in 6mons. What are the pharmacological properties of this
medication that cause the weight gain? Correct Answer - Blockade of 2a,
2c, d2 receptors
Drug induced parkinsonism is caused by a decrease of dopamine in which
pathway Correct Answer - nigrostriatal dopamine pathway
What Is the neurotransmitter that is needed for the activation of the AMPA
receptors? Correct Answer - Glutamate
What antipsychotic has low risk of metabolic effects Correct Answer -
Iloperidone (Fanapt)
What is the treatment for parkonsonism EPS effects? Correct Answer -
Symmetrel and Artane (amantadine or trihexyphenidyl)
What antipsychotic does not exceed 60% D2 occupancy? Correct Answer -
Clozapine
Solutions
What medication is most associated with increased prolactin Correct
Answer - Risperidal
Which medication is most associated with weight gain Correct Answer -
olanzapine
Second Generation is mainly associated with which side effects? Correct
Answer - Weight gain, hypercholesterolemia, altered glucose tolerance
insulin secretion
First Generation is mainly associated with which side effects? Correct
Answer - TD, EPS
Why is olanzapine associated with weight gain? Correct Answer - High
affinity for 2c receptors
What are the rating scales used to evaluate abnormal movements associated
with psychotropic medication? Correct Answer - SMARTS , AIMS,
PANAS- self report questionnaire, SAGE,
PHQ-depression, COWS-Opioid withdrawl
What is the black box warning of Clozapine Correct Answer -
Agranulocytosis
What is the most common side effect of clozapine Correct Answer -
sedation
What labs need to be done before starting clients on antipsychotic
medications? Correct Answer - fasting lipid panel, fasting glucose,
weight, bp
When someone with schizophrenia is on an atypical antipsychotic with
complaints of increased fatigue, which antipsychotic would you switch to?
Correct Answer - Abilify
, Patient has been on an atypical antipsychotic for 6weeks with unchanged
weight. Do you think that weight would be a good predictor of fasting
triglycerides Correct Answer - no
What is the pathway responsible for regulation of dopamine in the
hypothalamus Correct Answer - mesolimbic pathway
What antidepressant should be avoided for a patient on clozapine? Correct
Answer - Fluvox, paroxetine, sertraline (in large doses)
If a patient is experiencing breast milk secretion while receiving a med that
may stimulate breast secretions which medication could be switched to that
does not have increased prolactin as a side effect? Correct Answer -
Seroquel or zyprexa
What is the pharmacological explanation of the resolution of breast secretion
Correct Answer - decreased dopamine- increased prolactin
Increased serotonin- increased prolactin
Patient gains 25lbs in 6mons. What are the pharmacological properties of this
medication that cause the weight gain? Correct Answer - Blockade of 2a,
2c, d2 receptors
Drug induced parkinsonism is caused by a decrease of dopamine in which
pathway Correct Answer - nigrostriatal dopamine pathway
What Is the neurotransmitter that is needed for the activation of the AMPA
receptors? Correct Answer - Glutamate
What antipsychotic has low risk of metabolic effects Correct Answer -
Iloperidone (Fanapt)
What is the treatment for parkonsonism EPS effects? Correct Answer -
Symmetrel and Artane (amantadine or trihexyphenidyl)
What antipsychotic does not exceed 60% D2 occupancy? Correct Answer -
Clozapine
