Drugs
Reviewed
Drug Use Mechanism Side effects
fluoxetine, sertraline, depression, long term selective serotonin reuptake low libido, emotional blunting,
paroxetine anxiety (>4wks) inhibitor (SSRI) serotonin syndrome
venlafaxine, serotonin and noradrenaline
depression insomnia, hypertension
duloxetine reuptake inhibitor (SNRI)
reboxetine,
noradrenaline specific reuptake
buproprion, depression insomnia
inhibitor (NSRI)
maproteline
amitriptiline, depression, tricyclic antidepressant (blocks
toxic (cardio), seizures, suicide
imipramine neuropathic pain NA, 5HT, his and mAChR)
depression,
selegiline, rasagiline monoamine oxidase B inhibitor tyramine shock, nausea
parkinsons
moclobenamide depression reversible MAOAI ‘’
phenelzine depression irreversible MAOI ‘’
experimental model of blocks VMAT > depletion of
reserpine depression, parkinsons?
depression monoamine from vesicles
vet anaesthetic, rapid non competitive NMDA antag,
ketamine benefit for increases sypnaptogenesis and schizophrenic-like symptoms
depression? BDNF in prefrontal cortex
recreational drug -
phencyclidine NMDA antag ‘’
angel dust
noradrenaline serotonin
specific antagonist (NSSA) -
mirtazapine depression weight gain
5HT1a and a2 antag to block
autoinhibition
depression, quitting
smoking, anxiety (no
5HT1a ag > desensitisation of
sedation and
buspirone autoinhibitor effect so inc
dependence but
release
longer onset than
benzos)
psychotropic
5HT2 ag, promotes plasticity in
psilocybin (LSD) recreational drug,
prefrontal cortex?
depression?
unknown - maybe Na mimic to teratogenicity, dehydration,
bipolar, some unipolar
lithium block NA and inc 5HT nephrotoxic, hypothyroidism,
depression
synthesis? GSK3 inhibition? fatal in OD, goiter
Drugs 1
, Drug Use Mechanism Side effects
bipolar (effective on
agranulocytosis, ataxia, diplopia,
mania only), epilepsy use dependent VGSC block (for
hypersensitivity, megaloblastic
carbamazepine (not absence), inactive form), GABA ag? VGCC
anemia, cytochrome p450
neuropathic pain block?
inducer
(frontline)
hirsutism, gingival hyperplasia,
use dependent VGSC block (for
phenytoin epilepsy (not absence) cytochrome p450 inducer,
inactive form), VGCC block?
teratogenic
bipolar (for mania), all
VGSC block, GABA ag? teratogenic, hepatotoxic,
valproate types epilepsy,
transaminase antag? thrombocytopenia
neuropathic pain
use dependent VGSC/VGCC
bipolar, all
lamotrigine block, 5HT3 antag, inhibits teratogenic, fatal dermatitis
typesepilepsy
glutamate release
weight gain, anticholinergic (dry
mouth etc), hypotension,
schizophrenia,
gynacomasteia,
bipolar?, antag to D2 ≥ a adreno > 5HT2,
chlorpromazine pseudoparkinsonism,akasthasia,
huntingtons/tourettes mACh, D1, his
acute dystonia, tardive
tics
dyskinesia, neuroleptic
malignant syndrome
haloperidol ‘’ ‘’ more potent ‘’ + cardiac arrhythmias
metabolic (T2D, weight gain),
olanzapine, clozapine, schizophrenia, antag to 5HT2 > D4 > D2, a,
anticholinergic, clozapine only
risperidone depression? bipolar? mACh, his
risk agranulocytosis
D2R partial ag: inc activity in
aripiprazole schizophrenia mesocortical/nigrostriatal, dec akasthasia
in mesolimbic
NMDA ag, promotes
d-cycloserine schizophrenia
neuroplasticity
benztropine,
benzhexol, parkinsons tremor,
dry mouth, constipation,
procyclidine, schizophrenic mAChR antag
confusion
biperiden, pseudoparkinsonism
orphenadrine
GABAa PAM (inc duration of toxic in OD, induces cytochrome
epilepsy (1st line in opening), at high doses direct p450 so drug interactions,
barbituates eg.
neonatal), euthanasia, ag + ag to glycine + block of CNS/respiratory depression,
phenobarbitol
anaesthetic VGCC/nACh/AMPA/5HT3/VGSC addiction/tolerance,
etc megaloblastic anemia
anaesthesia/amnesiac,
sedation, addiction, toxic OD,
IM epilepsy (not benzo - GABAa PAM (inc
midazolam dec REM sleep, enhance effects
absence) - v short half frequency opening)
of drugs/alcohol
life
Drugs 2
Reviewed
Drug Use Mechanism Side effects
fluoxetine, sertraline, depression, long term selective serotonin reuptake low libido, emotional blunting,
paroxetine anxiety (>4wks) inhibitor (SSRI) serotonin syndrome
venlafaxine, serotonin and noradrenaline
depression insomnia, hypertension
duloxetine reuptake inhibitor (SNRI)
reboxetine,
noradrenaline specific reuptake
buproprion, depression insomnia
inhibitor (NSRI)
maproteline
amitriptiline, depression, tricyclic antidepressant (blocks
toxic (cardio), seizures, suicide
imipramine neuropathic pain NA, 5HT, his and mAChR)
depression,
selegiline, rasagiline monoamine oxidase B inhibitor tyramine shock, nausea
parkinsons
moclobenamide depression reversible MAOAI ‘’
phenelzine depression irreversible MAOI ‘’
experimental model of blocks VMAT > depletion of
reserpine depression, parkinsons?
depression monoamine from vesicles
vet anaesthetic, rapid non competitive NMDA antag,
ketamine benefit for increases sypnaptogenesis and schizophrenic-like symptoms
depression? BDNF in prefrontal cortex
recreational drug -
phencyclidine NMDA antag ‘’
angel dust
noradrenaline serotonin
specific antagonist (NSSA) -
mirtazapine depression weight gain
5HT1a and a2 antag to block
autoinhibition
depression, quitting
smoking, anxiety (no
5HT1a ag > desensitisation of
sedation and
buspirone autoinhibitor effect so inc
dependence but
release
longer onset than
benzos)
psychotropic
5HT2 ag, promotes plasticity in
psilocybin (LSD) recreational drug,
prefrontal cortex?
depression?
unknown - maybe Na mimic to teratogenicity, dehydration,
bipolar, some unipolar
lithium block NA and inc 5HT nephrotoxic, hypothyroidism,
depression
synthesis? GSK3 inhibition? fatal in OD, goiter
Drugs 1
, Drug Use Mechanism Side effects
bipolar (effective on
agranulocytosis, ataxia, diplopia,
mania only), epilepsy use dependent VGSC block (for
hypersensitivity, megaloblastic
carbamazepine (not absence), inactive form), GABA ag? VGCC
anemia, cytochrome p450
neuropathic pain block?
inducer
(frontline)
hirsutism, gingival hyperplasia,
use dependent VGSC block (for
phenytoin epilepsy (not absence) cytochrome p450 inducer,
inactive form), VGCC block?
teratogenic
bipolar (for mania), all
VGSC block, GABA ag? teratogenic, hepatotoxic,
valproate types epilepsy,
transaminase antag? thrombocytopenia
neuropathic pain
use dependent VGSC/VGCC
bipolar, all
lamotrigine block, 5HT3 antag, inhibits teratogenic, fatal dermatitis
typesepilepsy
glutamate release
weight gain, anticholinergic (dry
mouth etc), hypotension,
schizophrenia,
gynacomasteia,
bipolar?, antag to D2 ≥ a adreno > 5HT2,
chlorpromazine pseudoparkinsonism,akasthasia,
huntingtons/tourettes mACh, D1, his
acute dystonia, tardive
tics
dyskinesia, neuroleptic
malignant syndrome
haloperidol ‘’ ‘’ more potent ‘’ + cardiac arrhythmias
metabolic (T2D, weight gain),
olanzapine, clozapine, schizophrenia, antag to 5HT2 > D4 > D2, a,
anticholinergic, clozapine only
risperidone depression? bipolar? mACh, his
risk agranulocytosis
D2R partial ag: inc activity in
aripiprazole schizophrenia mesocortical/nigrostriatal, dec akasthasia
in mesolimbic
NMDA ag, promotes
d-cycloserine schizophrenia
neuroplasticity
benztropine,
benzhexol, parkinsons tremor,
dry mouth, constipation,
procyclidine, schizophrenic mAChR antag
confusion
biperiden, pseudoparkinsonism
orphenadrine
GABAa PAM (inc duration of toxic in OD, induces cytochrome
epilepsy (1st line in opening), at high doses direct p450 so drug interactions,
barbituates eg.
neonatal), euthanasia, ag + ag to glycine + block of CNS/respiratory depression,
phenobarbitol
anaesthetic VGCC/nACh/AMPA/5HT3/VGSC addiction/tolerance,
etc megaloblastic anemia
anaesthesia/amnesiac,
sedation, addiction, toxic OD,
IM epilepsy (not benzo - GABAa PAM (inc
midazolam dec REM sleep, enhance effects
absence) - v short half frequency opening)
of drugs/alcohol
life
Drugs 2
