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Gms 6552 Exam 1 2025 | Expert Verified Exam Questions & Answers

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GMS 6552 EXAM 1 2025 | EXPERT VERIFIED EXAM QUESTIONS & ANSWERS

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GMS 6552 EXAM 1 2025 | EXPERT VERIFIED
EXAM QUESTIONS & ANSWERS



Molecular Drug Targets - correct-answer-Receptors-45%
Enzymes-28%
Hormones-11%
Unknown-7%
Ion Channels-5%
DNA-4%




Channel-Linked (Ionotropic) Receptors - correct-answer-Produce cellular effects in
milliseconds
Nicotinic ACh receptor




GPCRs - correct-answer-Effects happen in seconds
Muscarinic ACh receptor




Kinase-linked receptors - correct-answer-Effects happen in minutes
Insulin receptor

,2|Page




Receptors linked to gene transcription - correct-answer-Effects happen in hours
Estrogen receptor




Heterotrimeric G proteins - correct-answer-alpha, beta and gamma subunits




GPCR Components - correct-answer-More than 800 receptors
7 transmembrane domains
N and C termini
Conformationally flexible
Constitutively active




GPCR Ligands - correct-answer-Hormones, neurotransmitters, chemokine, ions,
amino acids, peptides




G-proteins - correct-answer-a-20
Gas- increases AC
Gai - decreases AC

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Gaq - increases PLC
b(6)y(12)




Why use G proteins - correct-answer-Means of amplifying the signal
G proteins can regulate more than one effector




PKA - correct-answer-Phosphorylase Kinase (glycogen breakdown)
CREB (gene transcription)
L-type Ca channels (heart contraction)
Pyruvate Kinase (glycolysis)
Hormone Sensitive Lipase (triglyceride breakdown)




Agonist Activation of GPCR - correct-answer-Ligand binds
Promotes conformational changes
Increase in R




Inverse Agonist Inhibition of GPCR - correct-answer-Ligand binds
Stabilizes inactive receptor conformations

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