TEST BANK
cx
Genetics and Genomics in Nursing and Health Care
cx cx cx cx cx cx cx
Theresa A. Beery, M. Linda Workman, and Julia A. Eggert
cx cx cx cx cx cx cx cx cx
2nd Edition
cx
www.Plusbay.Plus
,Table of Contents
cx cx
Chaptercx01cxDNAcxStructurecxandcxFunction 1
Chaptercx02cxProteincxSynthesis 9
Chaptercx03cxGeneticcxInfluencecxoncxCellcxDivision,cxDifferentiation,cxandcxGametogenesis 19
Chaptercx04cxPatternscxofcxInheritance 29
Chaptercx05cxEpigeneticcxInfluencescxoncxGenecxExpression 43
Chaptercx06cxAutosomalcxInheritancecxandcxDisorders 47
Chaptercx07cxSexcxChromosomecxandcxMitochondrialcxInheritancecxandcxDisorders 55
Chaptercx08cxFamilycxHistorycxandcxPedigreecxConstruction 61
Chaptercx09cxCongenitalcxAnomalies,cxBasiccxDysmorphology,cxandcxGeneticcxAssessment 68
Chaptercx10cxEnzymecxandcxCollagencxDisorders 74
Chaptercx11cxCommoncxChildhood-OnsetcxGeneticcxDisorders 84
Chaptercx12cxCommoncxAdult-OnsetcxDisorders 95
Chaptercx13cxCardiovascularcxDisorders 103
Chaptercx14cxThecxGeneticscxofcxCancer 110
Chaptercx15cxGeneticcxContributionscxtocxPsychiatriccxandcxBehavioralcxDisorders 119
Chaptercx16cxGeneticcxandcxGenomiccxTesting 124
Chaptercx17cxAssessingcxGenomiccxVariationcxincxDrugcxResponse 129
Chaptercx18cxHealthcxProfessionalscxandcxGenomiccxCare 135
Chaptercx19cxFinancial,cxEthical,cxLegal,cxandcxSocialcxConsiderations 140
Chaptercx20cxGeneticcxandcxGenomiccxVariation 144
www.Plusbay.Plus
, TestcxBankcx-
cxGeneticscxandcxGenomicscxincxNursingcxandcxHealthcxCare,cx2ndcxEditioncx(Beery,cx2019)
Chaptercx1:cxDNAcxStructurecxandcxFunction
MULTIPLEcxCHOICE
1. Incxwhichcxbodycxorcxcellcxareacxarecxmostcxgenescxincxhumanscxlocated?
a. Nucleus
b. Mitochondrion
c. Cytoplasm
d. Plasmacxmembrane
ANS:c x c x A
MostcxgenescxarecxpartcxofcxthecxDNAcxlocatedcxincxthecxnucleuscxofcxbodycxcells.cxOnlycxacxfewcxgen
escxarecxlocatedcxincxacxcell’scxmitochondrioncxorcxmitochondria.cxTherecxarecxnocxgenescxorcxDNAcxi
ncxeithercxthecxcytoplasmcxorcxthecxplasmacxmembranescxofcxanycxcell.
2. Whichcxconditioncxorcxstatementcxexemplifiescxthecxconceptcxofcxgenomicscxrathercxthancxgenetics?
a. Thecxgenecxforcxinsulincxiscxlocatedcxoncxchromosomecx11cxincxallcxpeople.
b. Expressioncxofcxanycxsinglecxgenecxiscxdependentcxoncxinheritingcxtwocxalleles.
c. Sex-linkedcxrecessivecxdisorderscxaffectcxmalescxmorecxoftencxthancxfemales.
d. Onecxallelecxforcxeachcxgenecxiscxinheritedcxfromcxthecxmother,cxandcxonecxiscxinheritedcxf
romcxthecxfather.
ANS:c x c x A
Geneticscxiscxthecxstudycxofcxthecxgeneralcxmechanismscxofcxhereditycxandcxthecxvariationcxofcxinh
eritedcxtraits.cxGenomicscxiscxthecxstudycxofcxthecxfunctioncxofcxallcxthecxnucleotidecxsequencescxpr
esentcxwithincxthecxentirecxgenomecxofcxacxs p e c i e s , Wi nWcW
l u.d iTn B
g cxS
geMn.
esWiS
ncxDNAcxcodingcxregionsc
xandcxDNAcxnoncoding
regions.cxSelectionscxB,cxC,cxandcxDcxallcxrefercxtocxmechanismscxofcxheredity.cxOnlycxselectioncxAcxref
ers
tocxthecxfunctioncxofcxacxspecificcxnucleotidecxsequence.
3. WhatcxiscxthecxpurposecxofcxphosphorouscxincxacxDNAcxstrand?
a. Linkingcxthecxnucleotidescxintocxacxstrand
b. Holdingcxcomplementarycxstrandscxtogether
c. Ensuringcxthatcxacxpurinecxiscxalwayscxpairedcxwithcxacxpyrimidine
d. Preventingcxthecxseparationcxofcxdouble-strandedcxDNAcxintocxsingle-strandedcxDNA
ANS:c x c x A
Eachcxnucleosidecxbecomescxacxcompletecxnucleotidecxwhencxacxphosphatecxgroupcxiscxattached.cx
Thecxphosphatescxhavecxmultiplecxbindingcxsites,cxandcxeachcxonecxcancxlinkcxtocxtwocxnucleotide
s.cxThesecxlinkagescxallowcxthecxnucleotidescxtocxbecxconnectedcxwhencxplacedcxintocxthecxDNAcx
strand.cxThecxnucleotidescxwithincxeachcxstrandcxarecxheldcxincxpositioncxbycxthecxlinkedcxphospha
tecxgroups,cxwhichcxactcxlikecxthecxstringcxholdingcxacxstrandcxofcxbeadscxtogether,cxformingcxacxne
cklace.
4. Whatcxiscxthecxtermcxusedcxtocxdefinecxalternativecxformscxofcxacxgenecxthatcxmaycxresultcxincx
differentcxexpressioncxofcxthecxtraitcxcodedcxforcxbycxthatcxgene?
a. Alleles
b. Bases
c. Centromeres
d. Diploids
cx ANS:c x A
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| Pcxacxgcxe
cx cx
, TestcxBankcx-
cxGeneticscxandcxGenomicscxincxNursingcxandcxHealthcxCare,cx2ndcxEditioncx(Beery,cx2019)
Forcxeachcxsinglecxgene,cxtwocxalternativecxformscxofcxthatcxgene,cxknowncxascxalleles,cxtogethercxc
ontrolcxhowcxthatcxgenecxiscxexpressed.cxThecxallelescxmaycxbecxidenticalcxincxtheircxsequencecxbutcx
docxnotcxhavecxtocxbe.cxWhencxacxdominantcxallelecxiscxpairedcxwithcxacxrecessivecxallele,cxonlycxthe
cxdominantcxallelecxiscxexpressed,cxandcxthecxrecessivecxallelecxiscxsilent.cxWhencxacxdominantcxall
elecxiscxpairedcxwithcxanothercxdominantcxallele,cxtheycxarecxbothcxexpressedcx(usuallycxequally).cx
Recessivecxallelescxarecxonlycxexpressedcxwhencxtheycxarecxhomozygous.cxBasescxarecxthecxessent
ialcxpartcxofcxacxnucleotide,cxofcxwhichcxtherecxarecxmanycxwithincxanycxgenecxregion.cxCentromere
scxarecxthecxpinched-
incxpartcxofcxacxchromosomecxbetweencxthecxpcxarmscxandcxthecxqcxarms.cxThecxtermcxdiploidcxrefer
scxtocxthecxnormalcxnumbercxofcxchromosomecxpairscxwithincxacxcell.cxItcxiscxancxadjective,cxnotcxacx
noun.cxTherefore,cxthecxpluralcxdiploidscxdoescxnotcxexist.
5. Whatcxpercentagecxofcxbasescxincxacxstretchcxofcxdouble-
strandedcxDNAcxthatcxcontainscx30%cxguanine
(G)cxbasescxwouldcxbecxadeninecx(A)?
a. 70%
b. 60%
c. 30%
d. 20%
ANS:c x c x D
Becausecxofcxcomplementarycxpairing,cxifcx30%cxofcxthecxbasescxarecxguaninecx(G),cxwhichcxalwayscx
pairscxwithcxcytosinecxC,cxthesecxtwocxbasescxaccountcxforcx60%cxofcxthecxtotalcxbasescxincxthiscxstretc
h.cxThecxremainingcxbasescxmakecxupcx40%cxofcxthecxtotal.cxThiscx40%cxiscxcomposedcxofcxequalcxper
centagescxofcxthyminecx(T)cxandcxadeninecx(A).
6. Whatcxiscxthecxtermcxusedcxtocxdescribecxthecxorganizedcxpicturecxofcxthecxpairedcxchromosomescx
withincxacxcellcxusedcxtocxdeterminecxwhethercxchromosomecxnumbers,cxstructures,cxandcxbandin
gcxpatternscxare
normal? WWW.TBSM.WS
a. Pedigree
b. Phenotype
c. Karyotype
d. Autotype
ANS:c x c x C
Acxkaryotypecxiscxacxpicturecxofcxancxorganizedcxarrangementcxofcxallcxofcxthecxchromosomescxwit
hincxonecxcellcxduringcxthecxmetaphasecxsectioncxofcxmitosis.cxThecxchromosomescxarecxpairedcxan
dcxthencxarrangedcxbycxnumbercxaccordingcxtocxsizecxandcxcentromerecxposition.cxThecxbandingcxp
atterncxofcxeachcxpaircxiscxanalyzedcxtocxdeterminecxwhethercxareascxhavecxbeencxdeleted,cxexpand
ed,cxorcxtranslocated.cxAcxpedigreecxalsocxiscxacxpicture,cxbutcxitcxillustratescxseveralcxgenerationscx
ofcxacxfamilycxhistory.
Phenotypescxarecxobservablecxtraits.cxAutotypecxiscxnotcxacxgeneticcxterm.
7. WhatcxwouldcxbecxthecxsequencecxofcxDNAcxthatcxiscxcomplementarycxtocxacxDNAcxsectioncxwithcx
thecxbasecxsequencecxofcxGGTCAATCCTTAG?
a. GATTCCTAACTGG
b. TTGACCGAAGGCT
c. AACTGGCTTCCGA
d. CCAGTTAGGAATC
ANS:c x D
cx
www.Plusbay.Plus 2
| Pcxacxgcxe
cx cx
cx
Genetics and Genomics in Nursing and Health Care
cx cx cx cx cx cx cx
Theresa A. Beery, M. Linda Workman, and Julia A. Eggert
cx cx cx cx cx cx cx cx cx
2nd Edition
cx
www.Plusbay.Plus
,Table of Contents
cx cx
Chaptercx01cxDNAcxStructurecxandcxFunction 1
Chaptercx02cxProteincxSynthesis 9
Chaptercx03cxGeneticcxInfluencecxoncxCellcxDivision,cxDifferentiation,cxandcxGametogenesis 19
Chaptercx04cxPatternscxofcxInheritance 29
Chaptercx05cxEpigeneticcxInfluencescxoncxGenecxExpression 43
Chaptercx06cxAutosomalcxInheritancecxandcxDisorders 47
Chaptercx07cxSexcxChromosomecxandcxMitochondrialcxInheritancecxandcxDisorders 55
Chaptercx08cxFamilycxHistorycxandcxPedigreecxConstruction 61
Chaptercx09cxCongenitalcxAnomalies,cxBasiccxDysmorphology,cxandcxGeneticcxAssessment 68
Chaptercx10cxEnzymecxandcxCollagencxDisorders 74
Chaptercx11cxCommoncxChildhood-OnsetcxGeneticcxDisorders 84
Chaptercx12cxCommoncxAdult-OnsetcxDisorders 95
Chaptercx13cxCardiovascularcxDisorders 103
Chaptercx14cxThecxGeneticscxofcxCancer 110
Chaptercx15cxGeneticcxContributionscxtocxPsychiatriccxandcxBehavioralcxDisorders 119
Chaptercx16cxGeneticcxandcxGenomiccxTesting 124
Chaptercx17cxAssessingcxGenomiccxVariationcxincxDrugcxResponse 129
Chaptercx18cxHealthcxProfessionalscxandcxGenomiccxCare 135
Chaptercx19cxFinancial,cxEthical,cxLegal,cxandcxSocialcxConsiderations 140
Chaptercx20cxGeneticcxandcxGenomiccxVariation 144
www.Plusbay.Plus
, TestcxBankcx-
cxGeneticscxandcxGenomicscxincxNursingcxandcxHealthcxCare,cx2ndcxEditioncx(Beery,cx2019)
Chaptercx1:cxDNAcxStructurecxandcxFunction
MULTIPLEcxCHOICE
1. Incxwhichcxbodycxorcxcellcxareacxarecxmostcxgenescxincxhumanscxlocated?
a. Nucleus
b. Mitochondrion
c. Cytoplasm
d. Plasmacxmembrane
ANS:c x c x A
MostcxgenescxarecxpartcxofcxthecxDNAcxlocatedcxincxthecxnucleuscxofcxbodycxcells.cxOnlycxacxfewcxgen
escxarecxlocatedcxincxacxcell’scxmitochondrioncxorcxmitochondria.cxTherecxarecxnocxgenescxorcxDNAcxi
ncxeithercxthecxcytoplasmcxorcxthecxplasmacxmembranescxofcxanycxcell.
2. Whichcxconditioncxorcxstatementcxexemplifiescxthecxconceptcxofcxgenomicscxrathercxthancxgenetics?
a. Thecxgenecxforcxinsulincxiscxlocatedcxoncxchromosomecx11cxincxallcxpeople.
b. Expressioncxofcxanycxsinglecxgenecxiscxdependentcxoncxinheritingcxtwocxalleles.
c. Sex-linkedcxrecessivecxdisorderscxaffectcxmalescxmorecxoftencxthancxfemales.
d. Onecxallelecxforcxeachcxgenecxiscxinheritedcxfromcxthecxmother,cxandcxonecxiscxinheritedcxf
romcxthecxfather.
ANS:c x c x A
Geneticscxiscxthecxstudycxofcxthecxgeneralcxmechanismscxofcxhereditycxandcxthecxvariationcxofcxinh
eritedcxtraits.cxGenomicscxiscxthecxstudycxofcxthecxfunctioncxofcxallcxthecxnucleotidecxsequencescxpr
esentcxwithincxthecxentirecxgenomecxofcxacxs p e c i e s , Wi nWcW
l u.d iTn B
g cxS
geMn.
esWiS
ncxDNAcxcodingcxregionsc
xandcxDNAcxnoncoding
regions.cxSelectionscxB,cxC,cxandcxDcxallcxrefercxtocxmechanismscxofcxheredity.cxOnlycxselectioncxAcxref
ers
tocxthecxfunctioncxofcxacxspecificcxnucleotidecxsequence.
3. WhatcxiscxthecxpurposecxofcxphosphorouscxincxacxDNAcxstrand?
a. Linkingcxthecxnucleotidescxintocxacxstrand
b. Holdingcxcomplementarycxstrandscxtogether
c. Ensuringcxthatcxacxpurinecxiscxalwayscxpairedcxwithcxacxpyrimidine
d. Preventingcxthecxseparationcxofcxdouble-strandedcxDNAcxintocxsingle-strandedcxDNA
ANS:c x c x A
Eachcxnucleosidecxbecomescxacxcompletecxnucleotidecxwhencxacxphosphatecxgroupcxiscxattached.cx
Thecxphosphatescxhavecxmultiplecxbindingcxsites,cxandcxeachcxonecxcancxlinkcxtocxtwocxnucleotide
s.cxThesecxlinkagescxallowcxthecxnucleotidescxtocxbecxconnectedcxwhencxplacedcxintocxthecxDNAcx
strand.cxThecxnucleotidescxwithincxeachcxstrandcxarecxheldcxincxpositioncxbycxthecxlinkedcxphospha
tecxgroups,cxwhichcxactcxlikecxthecxstringcxholdingcxacxstrandcxofcxbeadscxtogether,cxformingcxacxne
cklace.
4. Whatcxiscxthecxtermcxusedcxtocxdefinecxalternativecxformscxofcxacxgenecxthatcxmaycxresultcxincx
differentcxexpressioncxofcxthecxtraitcxcodedcxforcxbycxthatcxgene?
a. Alleles
b. Bases
c. Centromeres
d. Diploids
cx ANS:c x A
www.Plusbay.Plus 1
| Pcxacxgcxe
cx cx
, TestcxBankcx-
cxGeneticscxandcxGenomicscxincxNursingcxandcxHealthcxCare,cx2ndcxEditioncx(Beery,cx2019)
Forcxeachcxsinglecxgene,cxtwocxalternativecxformscxofcxthatcxgene,cxknowncxascxalleles,cxtogethercxc
ontrolcxhowcxthatcxgenecxiscxexpressed.cxThecxallelescxmaycxbecxidenticalcxincxtheircxsequencecxbutcx
docxnotcxhavecxtocxbe.cxWhencxacxdominantcxallelecxiscxpairedcxwithcxacxrecessivecxallele,cxonlycxthe
cxdominantcxallelecxiscxexpressed,cxandcxthecxrecessivecxallelecxiscxsilent.cxWhencxacxdominantcxall
elecxiscxpairedcxwithcxanothercxdominantcxallele,cxtheycxarecxbothcxexpressedcx(usuallycxequally).cx
Recessivecxallelescxarecxonlycxexpressedcxwhencxtheycxarecxhomozygous.cxBasescxarecxthecxessent
ialcxpartcxofcxacxnucleotide,cxofcxwhichcxtherecxarecxmanycxwithincxanycxgenecxregion.cxCentromere
scxarecxthecxpinched-
incxpartcxofcxacxchromosomecxbetweencxthecxpcxarmscxandcxthecxqcxarms.cxThecxtermcxdiploidcxrefer
scxtocxthecxnormalcxnumbercxofcxchromosomecxpairscxwithincxacxcell.cxItcxiscxancxadjective,cxnotcxacx
noun.cxTherefore,cxthecxpluralcxdiploidscxdoescxnotcxexist.
5. Whatcxpercentagecxofcxbasescxincxacxstretchcxofcxdouble-
strandedcxDNAcxthatcxcontainscx30%cxguanine
(G)cxbasescxwouldcxbecxadeninecx(A)?
a. 70%
b. 60%
c. 30%
d. 20%
ANS:c x c x D
Becausecxofcxcomplementarycxpairing,cxifcx30%cxofcxthecxbasescxarecxguaninecx(G),cxwhichcxalwayscx
pairscxwithcxcytosinecxC,cxthesecxtwocxbasescxaccountcxforcx60%cxofcxthecxtotalcxbasescxincxthiscxstretc
h.cxThecxremainingcxbasescxmakecxupcx40%cxofcxthecxtotal.cxThiscx40%cxiscxcomposedcxofcxequalcxper
centagescxofcxthyminecx(T)cxandcxadeninecx(A).
6. Whatcxiscxthecxtermcxusedcxtocxdescribecxthecxorganizedcxpicturecxofcxthecxpairedcxchromosomescx
withincxacxcellcxusedcxtocxdeterminecxwhethercxchromosomecxnumbers,cxstructures,cxandcxbandin
gcxpatternscxare
normal? WWW.TBSM.WS
a. Pedigree
b. Phenotype
c. Karyotype
d. Autotype
ANS:c x c x C
Acxkaryotypecxiscxacxpicturecxofcxancxorganizedcxarrangementcxofcxallcxofcxthecxchromosomescxwit
hincxonecxcellcxduringcxthecxmetaphasecxsectioncxofcxmitosis.cxThecxchromosomescxarecxpairedcxan
dcxthencxarrangedcxbycxnumbercxaccordingcxtocxsizecxandcxcentromerecxposition.cxThecxbandingcxp
atterncxofcxeachcxpaircxiscxanalyzedcxtocxdeterminecxwhethercxareascxhavecxbeencxdeleted,cxexpand
ed,cxorcxtranslocated.cxAcxpedigreecxalsocxiscxacxpicture,cxbutcxitcxillustratescxseveralcxgenerationscx
ofcxacxfamilycxhistory.
Phenotypescxarecxobservablecxtraits.cxAutotypecxiscxnotcxacxgeneticcxterm.
7. WhatcxwouldcxbecxthecxsequencecxofcxDNAcxthatcxiscxcomplementarycxtocxacxDNAcxsectioncxwithcx
thecxbasecxsequencecxofcxGGTCAATCCTTAG?
a. GATTCCTAACTGG
b. TTGACCGAAGGCT
c. AACTGGCTTCCGA
d. CCAGTTAGGAATC
ANS:c x D
cx
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cx cx
