NBME PATHOLOGY FINAL EXAM
2025/2026 ACTUAL PREP QUESTIONS
AND ANSWERS GRADED A+
A 32-year-oId Rh-negative woman was delivered of her third child. She had not sought medical
care during pregnancy. Upon admission, / her saline agglutinin titer for Rh+ cells was 1:4, and
indirect antiglobulin (Coombs) test titer was 1:32. The infant had a hemoglobin of 10 g/dL and
became severely jaundiced, as her second child had been.
The greatest hazard for the infant is
kernicterus associated with an increased concentration of [conjugated or unconjugated] bilirubin
unconjugated (indirect) bilinibin
A standardized template bleeding time provides rapid assessment of functional adequacy of
[platelets or thrombin] platelets
Involvement of endothelial cells is most characteristic of infection with
rickettsiae
Severe cell injury due to ischemia is characterized by [increased or decreased] intracellular pH
decreased intracellular pH
Coagulation necrosis is most often h result of local [hyperemia or hypoxia] caused by loss of
blood supply
local hypoxia caused by loss of blood supply
Which of the following pigments will accumulate as the result of peroxidation of cell
membranes?
[Bilirubin or Lipochrome] Lipochrome
Cellular regeneration and restoration of normal morphology is possible in each of the following
conditions EXCEPT
diphtheritic myocarditis
,Severe cell injury caused by ischemia is characterized by [increased or decreased] intracellular
pH
decreased intracellular pH
Histologic grading systems to classify prostatic carcinoma were evaluated by investigators on
two separate occasions. Results were compared between the investigators as well as across
occasions for each investigator; The purpose of the multiple measurements was to establish the
[accuracy or reliability or validity] of the grading systems
establish the reliability of the grading systems
The pathogenesis of granulomatous reactions includes each of the following EXCEPT
antibodies
Development of tensile strength in a heal parallels the appearance of [collagen or fibroblasts]
collagen
The gross and microscopic characteristics used to differentiate benign from malignant neoplasms
have been proved by testing them for correlation with [analyses of chromosome number and con
figuration or behavior of neoplasms in human subjects]
behavior of neoplasms in human subjects
Visceral malignancy is associated with [acanthosis nigricans or vitiligo] acanthosis nigricans
The chance of finding a complete human leukocyte antigen (HLA) match between fraternal
siblings is
1:[2 or 4 or 6]
1:4
Splenectomy increases the risk for [pneumococcal infection or polycythemia vera]
pneumococcal infection
, Staphylococcus aureus causes infection in children with chronic granulomatous disease because
it is [catalase or coagulase]-positive
Catalase-positive
Grape-like clusters of avascular, hydropic chorionic
villi from the uterine cavity in the fourth month of pregnancy are associated with [paternal or
maternal] choriocarcinoma
associated with maternal choriocarcinoma
Gonorrheal infection in men is LEAST likely to involve:
testes
Which of the following features is LEAST likely to be expected in the cerebrospinal fluid (CSF)
of a patient with acute bacterial meningitis?
Normal protein concentration
Each of the following is a characteristic of the plaques seen in multiple sclerosis EXCEPT
early complete loss of axons
During the first two months of life, the microorganism most frequently responsible for
meningitis is
[Escherichia coli or Neisseria meningitidis] Escherichia coli
Multiple oligoclonal bands of immunoglobulins can be detected electrophoretically in the
cerebrospinal fluid of most patients with
[viral meningoencephalitis or multiple sclerosis] multiple sclerosis
Hypercalcemia with an increased plasma concentration of immunoreactive parathyroid hormone
is most characteristically associated with
[hyperthyroidism or primary hyperparathyroidism] primary hyperparathyroidism
A subdural hematoma is most likely to be associated with a traumatic tear of the
[bridging cerebral veins or middle cerebral artery] bridging cerebral veins
2025/2026 ACTUAL PREP QUESTIONS
AND ANSWERS GRADED A+
A 32-year-oId Rh-negative woman was delivered of her third child. She had not sought medical
care during pregnancy. Upon admission, / her saline agglutinin titer for Rh+ cells was 1:4, and
indirect antiglobulin (Coombs) test titer was 1:32. The infant had a hemoglobin of 10 g/dL and
became severely jaundiced, as her second child had been.
The greatest hazard for the infant is
kernicterus associated with an increased concentration of [conjugated or unconjugated] bilirubin
unconjugated (indirect) bilinibin
A standardized template bleeding time provides rapid assessment of functional adequacy of
[platelets or thrombin] platelets
Involvement of endothelial cells is most characteristic of infection with
rickettsiae
Severe cell injury due to ischemia is characterized by [increased or decreased] intracellular pH
decreased intracellular pH
Coagulation necrosis is most often h result of local [hyperemia or hypoxia] caused by loss of
blood supply
local hypoxia caused by loss of blood supply
Which of the following pigments will accumulate as the result of peroxidation of cell
membranes?
[Bilirubin or Lipochrome] Lipochrome
Cellular regeneration and restoration of normal morphology is possible in each of the following
conditions EXCEPT
diphtheritic myocarditis
,Severe cell injury caused by ischemia is characterized by [increased or decreased] intracellular
pH
decreased intracellular pH
Histologic grading systems to classify prostatic carcinoma were evaluated by investigators on
two separate occasions. Results were compared between the investigators as well as across
occasions for each investigator; The purpose of the multiple measurements was to establish the
[accuracy or reliability or validity] of the grading systems
establish the reliability of the grading systems
The pathogenesis of granulomatous reactions includes each of the following EXCEPT
antibodies
Development of tensile strength in a heal parallels the appearance of [collagen or fibroblasts]
collagen
The gross and microscopic characteristics used to differentiate benign from malignant neoplasms
have been proved by testing them for correlation with [analyses of chromosome number and con
figuration or behavior of neoplasms in human subjects]
behavior of neoplasms in human subjects
Visceral malignancy is associated with [acanthosis nigricans or vitiligo] acanthosis nigricans
The chance of finding a complete human leukocyte antigen (HLA) match between fraternal
siblings is
1:[2 or 4 or 6]
1:4
Splenectomy increases the risk for [pneumococcal infection or polycythemia vera]
pneumococcal infection
, Staphylococcus aureus causes infection in children with chronic granulomatous disease because
it is [catalase or coagulase]-positive
Catalase-positive
Grape-like clusters of avascular, hydropic chorionic
villi from the uterine cavity in the fourth month of pregnancy are associated with [paternal or
maternal] choriocarcinoma
associated with maternal choriocarcinoma
Gonorrheal infection in men is LEAST likely to involve:
testes
Which of the following features is LEAST likely to be expected in the cerebrospinal fluid (CSF)
of a patient with acute bacterial meningitis?
Normal protein concentration
Each of the following is a characteristic of the plaques seen in multiple sclerosis EXCEPT
early complete loss of axons
During the first two months of life, the microorganism most frequently responsible for
meningitis is
[Escherichia coli or Neisseria meningitidis] Escherichia coli
Multiple oligoclonal bands of immunoglobulins can be detected electrophoretically in the
cerebrospinal fluid of most patients with
[viral meningoencephalitis or multiple sclerosis] multiple sclerosis
Hypercalcemia with an increased plasma concentration of immunoreactive parathyroid hormone
is most characteristically associated with
[hyperthyroidism or primary hyperparathyroidism] primary hyperparathyroidism
A subdural hematoma is most likely to be associated with a traumatic tear of the
[bridging cerebral veins or middle cerebral artery] bridging cerebral veins
