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Essential Concepts of Human Pathophysiology: A Systems-Based Approach (7th Edition Reference Guide)

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This document is a detailed reference guide that explains the foundational mechanisms of human disease, focusing on physiological processes and system-based pathophysiology, tailored for health science and nursing students.

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Understanding Pathophysiology 7th edition by Huether, McCance
Test Bank

, Understanding Pathophysiology 7th edition by Huether, McCance Test Bank


Chapter 1. Cellular Biology

MULTIPLE CHOICE

1. A student is observing a cell under the microscope. It is observed to have
supercoiled DNA with histones. Which of the following would also be observed by
the student?
a. A single circular chromosome
b. A nucleus
c. Free-floating nuclear material
d. No organelles

ANS: B

The cell described is a eukaryotic cell, so it has histones and a supercoiled DNA
within its nucleus; thus, the nucleus should be observed.

A single circular chromosome is characteristic of prokaryotic cells, which do not
have histones.

Free-floating nuclear material describes a prokaryotic cell, which would not have a
distinct nucleus.

Eukaryotic cells have membrane bounded cellular components called organelles.
No organelles describes a prokaryotic cell.

2. A nurse is instructing the staff about cellular functions. Which cellular
function is the nurse describing when an isolated cell absorbs oxygen and uses it to
transform nutrients to energy?
a. Metabolic absorption
b. Communication
c. Secretion
d. Respiration



2

, Understanding Pathophysiology 7th edition by Huether, McCance Test Bank


ANS: D

The ability of the cell to absorb oxygen refers to the cells function of respiration.

The ability of the cell to function within a society of cells refers to its function of
communication.

The ability of the cell to take in nutrients refers to the cells function of metabolic
absorption.

The ability of the cell to synthesize new substances and secrete these elsewhere
refers to the cells function of secretion.

3. A eukaryotic cell is undergoing DNA replication. In which region of the cell
would most of the genetic information be contained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Nucleus

ANS: C

The region of the cell that contains genetic material, including a large amount of
ribonucleic acid, most of the DNA, and DNA-binding proteins, is the nucleolus.

The mitochondria is the site of cellular respiration.

The ribosomes are involved in manufacturing of proteins within the cell.

The nucleus contains the nucleolus, and it is the nucleolus that contains genetic
material.




3

, Understanding Pathophysiology 7th edition by Huether, McCance Test Bank

4. The fluid mosaic model for biologic membranes describes membrane
behavior. According to this model, which of the following float singly or as
aggregates in the fluid lipid bilayer?
a. Peripheral membrane proteins
b. Integral membrane proteins


c. Glycoproteins
d. Cell adhesion molecules

ANS: B

Integral membrane proteins float freely in the fluid lipid bilayer.

Peripheral membrane proteins are not embedded in the layer, but reside at the
surface. Glycoproteins act as cell surface markers.
Cell adhesion molecules are on the outside of the membrane and allow cells to
hook together.

5. Which of the following can bind to plasma membrane receptors?

a. Oxygen
b. Ribosomes
c. Amphipathic lipids
d. Ligands

ANS: D

Ligands are specific molecules that can bind with receptors on the cell membrane.
Oxygen moves by diffusion; it does not bind to receptors.
Ribosomes make proteins and are not involved in binding. Amphipathic lipids are a
portion of the cell membrane.
6. A nurse is reviewing a report from a patient with metastatic cancer. What
finding would support the diagnosis of metastatic cancer? Alterations in
extracellular matrix that include:

4

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