MSN 671 NEI GLOBAL VIDEO QUESTIONS &
ANSWERS
Communication between human CNS neurons at synapses is: - Answer -Chemical
An example of volume neurotransmission is: - Answer -Dopamine in the prefrontal
cortex
The direct role of transcription factors is to: - Answer -Influence gene expression
The term epigenetics refers to: - Answer -A process determining whether a given gene
is expressed or silenced
Presynaptic reuptake transporters are a major method of inactivation for which of the
following? - Answer -Serotonin and GABA
What is constitutive activity? - Answer -Signal transduction when no agonist or inverse
agonist is bound to the receptor.
A partial agonist has what effect on neurotransmission? - Answer -Net agonism when
neurotransmission is deficient.
Net antagonism when neurotransmission is excessive.
Both of the above answers are correct
Agonists cause ligand-gated ion channels to: - Answer -Open more frequently
Which of the following is true? - Answer -Both positive and negative allosteric
modulations are possible only in the presence of a neurotransmitter
The neurodevelopmental hypothesis of schizophrenia centers heavily around the idea
that aberrant competitive elimination occurs. Competitive elimination is a stage of
neurodevelopment in which: - Answer -Rarely used synapses are pruned, while
frequently used synapses are preserved.
What three neurotransmitter systems are implicated in the neuropathology of
psychosis? - Answer -Serotonin, glutamate, dopamine
What receptor subtypes act as presynaptic autoreceptors to inhibit serotonin release? -
Answer -5HT1A and 5HT1B/D receptors
Stimulation of 5HT3 receptors on GABA interneurons leads to inhibited release of: -
Answer -Acetylcholine, norepinephrine, and serotonin.
, Psychosis in Parkinson's disease or dementia may occur due to upregulation of which
postsynaptic serotonin receptor on glutamate neurons in the prefrontal cortex? -
Answer -5HT2A
Antagonism of dopamine 2 receptors in the mesolimbic/mesostriatal pathway may lead
to: - Answer -Improvement in positive symptoms of psychosis and development of
secondary negative symptoms.
A 44-year-old male with schizophrenia has been treated with a dopamine 2 receptor
antagonist since initial diagnosis twelve years ago. He has recently begun experiencing,
difficulty with fluid movement of his arms as well as involuntary facial grimaces. Which
of the following likely underlies these symptoms? - Answer -Upregulation of dopamine
2 receptors.
A 38-year-old woman was diagnosed with schizophrenia approximately two years ago
and after multiple trials of different medications has been maintained on haloperidol for
the last several months with good response. Two weeks ago she began exhibiting mild
motor symptoms representative of drug-induced parkinsonism. Which of the following
would be the most appropriate adjunct medication for this patient? - Answer -
Muscarinic 1 antagonist
A 44-year-old woman with schizophrenia has developed tardive dyskinesia after taking
haloperidol 15 mg/day for 2 years. Which of the following would be the most appropriate
pharmacologic mechanism to manage her tardive dyskinesia? - Answer -Inhibition of
vesicular monoamine transporter 2
Sam is a 76-year-old patient with Parkinson's disease psychosis who demonstrated a
reduction in psychotic symptoms with no exacerbation of motor symptoms following
treatment with dopamine 2/serotonin 1A partial agonist. Where on the dopamine agonist
spectrum did her medication most likely fall? - Answer -Nearly full dopamine agonist
The majority of drugs to treat psychosis: - Answer -Have higher affinity for serotonin 2
A receptors than for dopamine 2 receptors.
When voltage-sensitive sodium channels are open and activated, the flow of sodium is:
- Answer -Into the neuron
Which of the following are involved in regulating neurotransmission via excitation-
secretion coupling? - Answer -Both of these which are voltage-sensitive sodium
channels and voltage-sensitive calcium channels.
A 21-year-old man who has just been diagnosed with schizophrenia presents with his
parents. He speaks with a reserved and simple language processing style; he is able to
understand and relate to simple questions but seems to get lost when the pace of the
conversation between the clinician and parents accelerates. when reviewing the
patient's history, what pattern of cognitive functioning prior to psychosis onset would you
ANSWERS
Communication between human CNS neurons at synapses is: - Answer -Chemical
An example of volume neurotransmission is: - Answer -Dopamine in the prefrontal
cortex
The direct role of transcription factors is to: - Answer -Influence gene expression
The term epigenetics refers to: - Answer -A process determining whether a given gene
is expressed or silenced
Presynaptic reuptake transporters are a major method of inactivation for which of the
following? - Answer -Serotonin and GABA
What is constitutive activity? - Answer -Signal transduction when no agonist or inverse
agonist is bound to the receptor.
A partial agonist has what effect on neurotransmission? - Answer -Net agonism when
neurotransmission is deficient.
Net antagonism when neurotransmission is excessive.
Both of the above answers are correct
Agonists cause ligand-gated ion channels to: - Answer -Open more frequently
Which of the following is true? - Answer -Both positive and negative allosteric
modulations are possible only in the presence of a neurotransmitter
The neurodevelopmental hypothesis of schizophrenia centers heavily around the idea
that aberrant competitive elimination occurs. Competitive elimination is a stage of
neurodevelopment in which: - Answer -Rarely used synapses are pruned, while
frequently used synapses are preserved.
What three neurotransmitter systems are implicated in the neuropathology of
psychosis? - Answer -Serotonin, glutamate, dopamine
What receptor subtypes act as presynaptic autoreceptors to inhibit serotonin release? -
Answer -5HT1A and 5HT1B/D receptors
Stimulation of 5HT3 receptors on GABA interneurons leads to inhibited release of: -
Answer -Acetylcholine, norepinephrine, and serotonin.
, Psychosis in Parkinson's disease or dementia may occur due to upregulation of which
postsynaptic serotonin receptor on glutamate neurons in the prefrontal cortex? -
Answer -5HT2A
Antagonism of dopamine 2 receptors in the mesolimbic/mesostriatal pathway may lead
to: - Answer -Improvement in positive symptoms of psychosis and development of
secondary negative symptoms.
A 44-year-old male with schizophrenia has been treated with a dopamine 2 receptor
antagonist since initial diagnosis twelve years ago. He has recently begun experiencing,
difficulty with fluid movement of his arms as well as involuntary facial grimaces. Which
of the following likely underlies these symptoms? - Answer -Upregulation of dopamine
2 receptors.
A 38-year-old woman was diagnosed with schizophrenia approximately two years ago
and after multiple trials of different medications has been maintained on haloperidol for
the last several months with good response. Two weeks ago she began exhibiting mild
motor symptoms representative of drug-induced parkinsonism. Which of the following
would be the most appropriate adjunct medication for this patient? - Answer -
Muscarinic 1 antagonist
A 44-year-old woman with schizophrenia has developed tardive dyskinesia after taking
haloperidol 15 mg/day for 2 years. Which of the following would be the most appropriate
pharmacologic mechanism to manage her tardive dyskinesia? - Answer -Inhibition of
vesicular monoamine transporter 2
Sam is a 76-year-old patient with Parkinson's disease psychosis who demonstrated a
reduction in psychotic symptoms with no exacerbation of motor symptoms following
treatment with dopamine 2/serotonin 1A partial agonist. Where on the dopamine agonist
spectrum did her medication most likely fall? - Answer -Nearly full dopamine agonist
The majority of drugs to treat psychosis: - Answer -Have higher affinity for serotonin 2
A receptors than for dopamine 2 receptors.
When voltage-sensitive sodium channels are open and activated, the flow of sodium is:
- Answer -Into the neuron
Which of the following are involved in regulating neurotransmission via excitation-
secretion coupling? - Answer -Both of these which are voltage-sensitive sodium
channels and voltage-sensitive calcium channels.
A 21-year-old man who has just been diagnosed with schizophrenia presents with his
parents. He speaks with a reserved and simple language processing style; he is able to
understand and relate to simple questions but seems to get lost when the pace of the
conversation between the clinician and parents accelerates. when reviewing the
patient's history, what pattern of cognitive functioning prior to psychosis onset would you
