GMS 6552 Exam 1 with verified answers graded A+
passed
1. Molecular
Receptors-
Drug Targets
45%
Enzymes-
28%
Hormones-
11%
2. Channel- Unknown-
Linked 7% Ion
(Ionotropic) Channels-5%
Receptors DNA-4%
Produce cellular ettects in milliseconds
Nicotinic ACh receptor
3. GPCRs Ettects happen in
seconds Muscarinic
ACh receptor
4. Kinase-linked Ettects happen in minutes
re- ceptors Insulin receptor
5. Receptors Ettects happen in hours
linked to gene
Estrogen receptor
tran- scription
6. Heterotrimeri
alpha, beta and gamma subunits
c G proteins
7. GPCR
Compo- More than 800 receptors
nents 7 transmembrane
domains N and C
1/
28
,GMS 6552 Exam 1 with verified answers graded A+
passed
t mini Conformationally
e flexible Constitutively
r active
8. GPCR Ligands Hormones, neurotransmitters, chemokine, ions, amino acids, peptides
9. G-proteins
2/
28
,GMS 6552 Exam 1 with verified answers graded A+
passed
a-20
Gas- increases AC Gai -
decreases AC Gaq
- increases PLC
b(6)y(12)
10. Why use G Means of amplifying the signal
pro- teins G proteins can regulate more than one ettector
11. PKA Phosphorylase Kinase (glycogen
breakdown) CREB (gene
transcription)
L-type Ca channels (heart
contraction) Pyruvate Kinase
(glycolysis)
Hormone Sensitive Lipase (triglyceride breakdown)
12. Kinase-linked No second messenger
re- ceptor
signaling
Receptors associated with cytosolic kinases
13. Protein ki-
Receptor tyrosine kinases
nase-linked
Receptor serine/threonine kinases
re- ceptors
14. Receptors associ- Ligands:
ated with cytoso- kinases
lic kinases
15. Receptor
tyro- sine
3/
28
passed
1. Molecular
Receptors-
Drug Targets
45%
Enzymes-
28%
Hormones-
11%
2. Channel- Unknown-
Linked 7% Ion
(Ionotropic) Channels-5%
Receptors DNA-4%
Produce cellular ettects in milliseconds
Nicotinic ACh receptor
3. GPCRs Ettects happen in
seconds Muscarinic
ACh receptor
4. Kinase-linked Ettects happen in minutes
re- ceptors Insulin receptor
5. Receptors Ettects happen in hours
linked to gene
Estrogen receptor
tran- scription
6. Heterotrimeri
alpha, beta and gamma subunits
c G proteins
7. GPCR
Compo- More than 800 receptors
nents 7 transmembrane
domains N and C
1/
28
,GMS 6552 Exam 1 with verified answers graded A+
passed
t mini Conformationally
e flexible Constitutively
r active
8. GPCR Ligands Hormones, neurotransmitters, chemokine, ions, amino acids, peptides
9. G-proteins
2/
28
,GMS 6552 Exam 1 with verified answers graded A+
passed
a-20
Gas- increases AC Gai -
decreases AC Gaq
- increases PLC
b(6)y(12)
10. Why use G Means of amplifying the signal
pro- teins G proteins can regulate more than one ettector
11. PKA Phosphorylase Kinase (glycogen
breakdown) CREB (gene
transcription)
L-type Ca channels (heart
contraction) Pyruvate Kinase
(glycolysis)
Hormone Sensitive Lipase (triglyceride breakdown)
12. Kinase-linked No second messenger
re- ceptor
signaling
Receptors associated with cytosolic kinases
13. Protein ki-
Receptor tyrosine kinases
nase-linked
Receptor serine/threonine kinases
re- ceptors
14. Receptors associ- Ligands:
ated with cytoso- kinases
lic kinases
15. Receptor
tyro- sine
3/
28
