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ATI Medical-Surgical Nursing – Immune & Infection Exam | 2025–2026 | Verified Real Questions & Correct Answers – Complete NCLEX-Style Prep

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This document contains a comprehensive set of real ATI-style multiple-choice questions and verified answers for the Med-Surg Immune and Infection Exam, relevant for the 2025–2026 academic year. It includes high-yield topics such as HIV/AIDS care, systemic lupus erythematosus (SLE), tuberculosis precautions, herpes zoster, autoimmune conditions, immune responses, and medication-related teaching. This is a fully detailed prep resource designed for nursing students preparing for exams or NCLEX.

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ATI MED SURG IMMUNE & INFECTION Exam
2025–2026 Accurate Real Exam Questions and
Verified Correct Answers JUST RELEASED
A nurse is planning care for a client who has AIDS and has developed stomatitis. Which of
the following interventions should the nurse include in the plan of care?
A. Rinse the mouth with chlorhexidine solution every 2 hr
B. Limit fluid intake with meals
C. Provide oral hygiene with a firm-bristled toothbrush after each meal
D. Avoid salty foods - answer>>>D. Avoid salty foods


A nurse is evaluating the injection site of a client who had a Mantoux skin test 48 hr ago.
The nurse finds 10 mm of induration with slight redness. Which of the following
conclusions should the nurse make?
A. The client has active tuberculosis.
B. The client had an exposure to tuberculosis.
C. The nurse must re-evaluate the result in 24 hr.
D. The test is negative for tuberculosis. - answer>>>B. The client had an exposure to
tuberculosis.


A nurse is working with an assistive personnel (AP) who is assigned to bathe a client with
herpes zoster. The AP asks the nurse if herpes zoster is contagious. Which of the
following responses should the nurse make?
A. "Adults receive natural immunity to herpes zoster from casual exposure to children
who have had chickenpox."
B. "Herpes zoster is not contagious to individuals who received an MMR vaccine as an
infant."
C. "A client who has herpes zoster is not contagious if blisters are present on the skin."

,D. "Herpes zoster is not contagious to people who have had chickenpox." - answer>>>D.
"Herpes zoster is not contagious to people who have had chickenpox."


A nurse is caring for a client who is concerned about the possibility of contracting Lyme
disease after receiving a tick bite. For which of the following early manifestations of Lyme
disease should the nurse assess the client?
A. Diffuse maculopapular rash
B. Dyspnea
C. Double vision
D. Progressive circular rash - answer>>>D. Progressive circular rash


A nurse is providing dietary teaching for a client with AIDS who has stomatitis of the
mouth. Which of the following instructions should the nurse include in the teaching?
A. "You can suck on popsicles to numb your mouth."
B. "Season food with spices instead of salt."
C. "Avoid the use of a straw to drink liquids."
D. "Eat foods at hot temperatures." - answer>>>A. "You can suck on popsicles to numb
your mouth."


A nurse is caring for a client who underwent radioallergosorbent (RAST) testing due to
seasonal allergies. The nurse should anticipate an elevation in which of the following
immunoglobulin laboratory values?
A. IgM
B. IgA
C. IgG
D. IgE - answer>>>D. IgE

, A nurse is teaching a client who was recently diagnosed with Raynaud's disease about
preventing the onset of manifestations. Which of the following statements by the client
indicates an understanding of the teaching?
A. "I should limit my exposure to sunlight."
B. "I should avoid drinking alcohol."
C. "I should not smoke."
D. "I should limit of intake of foods that are high in purine." - answer>>>C. "I should not
smoke."


A nurse is preparing to administer a Mantoux skin test to a client. What is the purpose of
a Mantoux skin test using purified protein derivative (PPD)?
A. To identify if a client lacks immunity to tuberculosis
B. To find out if a client has active tuberculosis
C. To decrease the hypersensitivity of the client's reaction to PPD
D. To identify if a client has been infected with Mycobacterium tuberculosis -
answer>>>D. To identify if a client has been infected with Mycobacterium tuberculosis


A nurse is providing discharge teaching to a client who has a new diagnosis of systemic
lupus erythematosus (SLE). Which of the following statements by the client indicates an
understanding of the teaching?
A. "I will need to take methotrexate, even if I'm in remission."
B. "I'm thankful that this type of lupus only affects the skin."
C. "Each day, I should apply a sunblock with a sun protection factor of 15."
D. "A mild fever is common with SLE and usually does not require medical intervention." -
answer>>>A. "I will need to take methotrexate, even if I'm in remission."


A nurse is teaching a client with systemic lupus erythematosus who has a new
prescription for prednisone. The nurse should instruct the client to monitor for which of
the following adverse effects of this medication?

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