Advanced Pharm Final Exam 2025-2026
1. Charlie Is A 65-Year-Old Male Who Has Been Diagnosed With Hypertension
And Benign Prostatic Hyperplasia. Doxazosin Has Been Chosen To Treat His
Hypertension Because It:
1. Increases Peripheral Vasoconstriction
2. Decreases Detrusor Muscle Contractility
3. Lowers Supine Blood Pressure More Than Standing Pressure
4. Relaxes Smooth Muscle In The Bladder Neck
4. Relaxes Smooth Muscle In The Bladder Neck
2. To Reduce Potential Adverse Effects, Patients Taking A Peripherally Acting
Alpha1 Antagonist Should Do All Of The Following Except:
1. Take The Dose At Bedtime
2. Sit Up Slowly And Dangle Their Feet Before Standing
3. Monitor Their Blood Pressure And Skip A Dose If The Pressure Is Less Than
120/80
4. Weigh Daily And Report Weight Gain Of Greater Than 2 Pounds In One Day
3. Monitor Their Blood Pressure And Skip A Dose If The Pressure Is Less Than
120/80
3. John Has Clonidine, A Centrally-Acting Adrenergic Blocker, Prescribed For
His Hypertension. He Should:
1. Not Miss A Dose Or Stop Taking The Drug Because Of Potential Rebound
Hypertension
2. Increase Fiber In The Diet To Treat Any Diarrhea That May Occur
3. Reduce Fluid Intake To Less Than 2 Liters Per Day To Prevent Fluid
Retention
4. Avoid Sitting For Long Periods, As This Can Lead To Deep Vein Thrombosis
1. Not Miss A Dose Or Stop Taking The Drug Because Of Potential Rebound
Hypertension
4. Clonidine Has Several Off-Label Uses, Including:
1. Alcohol And Nicotine Withdrawal
2. Post-Herpetic Neuralgia
3. Both 1 And 2
4. Neither 1 Nor 2
, 3. Both 1 And 2
5. Jim Is Being Treated For Hypertension. Because He Has A History Of Heart
Attacks, The Drug Chosen Is Atenolol. Beta-Blockers Treat Hypertension By:
1. Increasing Heart Rate To Improve Cardiac Output
2. Reducing Vascular Smooth Muscle Tone
3. Increasing Aldosterone-Mediated Volume Activity
4. Reducing Aqueous Humor Production
2. Reducing Vascular Smooth Muscle Tone
6. Which Of The Following Adverse Effects Are Less Likely In A Beta 1-Selective
Blocker?
1. Dysrhythmias
2. Impaired Insulin Release
3. Reflex Orthostatic Changes
4. Decreased Triglycerides And Cholesterol
2 . Impaired insulin release
7. Richard Is 70 Years Old And Has A History Of Cardiac Dysrhythmias. He Has
Been Prescribed Nadolol. You Do His Annual Laboratory Work And Find A
Crcl Of 25 Ml/Min. What Action Should You Take Related To His Nadolol?
1. Extend The Dosage Interval.
2. Decrease The Dose By 75%.
3. Take No Action Because This Value Is Expected In The Older Adult.
4. Schedule A Serum Creatinine Level To Validate The Crcl Value.
1 . Extend the dosage interval.
8. Beta Blockers Are The Drugs Of Choice For Exertional Angina Because They:
1. Improve Myocardial Oxygen Supply By Vasodilating The Coronary Arteries 2.
Decrease Myocardial Oxygen Demand By Decreasing Heart Rate And
Vascular Resistance 3. Both 1 And 2
4. Neither 1 Nor 2
2. Decrease Myocardial Oxygen Demand By Decreasing Heart Rate And
Vascular Resistance
9. Adherence To Beta-Blocker Therapy May Be Affected By Their:
, 1. Short Half-Lives Requiring Twice Daily Dosing
2. Tendency To Elevate Lipid Levels
3. Effects On The Male Genitalia, Which May Produce Impotence
4. None Of The Above
3. Effects On The Male Genitalia, Which May Produce Impotence
10. Beta-Blockers Have Favorable Effects On Survival And Disease Progression
In Heart Failure. Treatment Should Be Initiated When The:
1. Symptoms Are Severe
2. Patient Has Not Responded To Other Therapies
3. Patient Has Concurrent Hypertension
4. Left Ventricular Dysfunction Is Diagnosed
4 . Left ventricular dysfunction is diagnosed
11. Abrupt Withdrawal Of Beta Blockers Can Be Life-Threatening. Patients At The
Highest Risk For Serious Consequences Of Rapid Withdrawal Are Those
With:
1. Angina
2. Coronary Artery Disease
3. Both 1 And 2
4. Neither 1 Nor 2
3 . Both 1 and 2
12. To Prevent Life-Threatening Events From Rapid Withdrawal Of A Beta
Blocker:
1. The Dosage Interval Should Be Increased By 1 Hour Each Day.
2. An Alpha Blocker Should Be Added To The Treatment Regimen Before
Withdrawal.
3. The Dosage Should Be Tapered Over A Period Of Weeks.
4. The Dosage Should Be Decreased By One-Half Every 4 Days.
4. The Dosage Should Be Decreased By One-Half Every 4 Days.
13. Beta-Blockers Are Prescribed For Diabetics With Caution Because Of Their
Ability To Produce Hypoglycemia And Block The Common Symptoms Of It.
Which Of The Following Symptoms Of Hypoglycemia Is Not Blocked By These
Drugs And So Can Be Used To Warn Diabetics Of Possible Decreased Blood
Glucose?
, 1. Dizziness
2. Increased Heart Rate
3. Nervousness And Shakiness
4. Diaphoresis
4. Diaphoresis
14. Combined Alpha-Beta Antagonists Are Used To Reduce The Progression Of
Heart Failure Because They:
1. Vasodilate The Peripheral Vasculature
2. Decrease Cardiac Output
3. Increase Renal Vascular Resistance
4. Reduce Atherosclerosis Secondary To Elevated Serum Lipoproteins
1. Vasodilate The Peripheral Vasculature
15. Carvedilol Is Heavily Metabolized By Cyp2d6 And 2c9, Resulting In Drug
Interactions With Which Of The Following Drug Classes?
1. Histamine 2 Blockers
2. Quinolones
3. Serotonin Re-Uptake Inhibitors
4. All Of The Above
4 . All of the above
16. Alpha-Beta Blockers Are Especially Effective In Treating Hypertension For
Which Ethnic Group?
1. White
2. Asian
3. African American
4. Native American
3. African American
17. Bethanechol:
1. Increases Detrusor Muscle Tone To Empty The Bladder
2. Decreases Gastric Acid Secretion To Treat Peptic Ulcer Disease
3. Stimulates Voluntary Muscle Tone To Improve Strength
4. Reduces Bronchial Airway Constriction To Treat Asthma
1. Increases Detrusor Muscle Tone To Empty The Bladder
1. Charlie Is A 65-Year-Old Male Who Has Been Diagnosed With Hypertension
And Benign Prostatic Hyperplasia. Doxazosin Has Been Chosen To Treat His
Hypertension Because It:
1. Increases Peripheral Vasoconstriction
2. Decreases Detrusor Muscle Contractility
3. Lowers Supine Blood Pressure More Than Standing Pressure
4. Relaxes Smooth Muscle In The Bladder Neck
4. Relaxes Smooth Muscle In The Bladder Neck
2. To Reduce Potential Adverse Effects, Patients Taking A Peripherally Acting
Alpha1 Antagonist Should Do All Of The Following Except:
1. Take The Dose At Bedtime
2. Sit Up Slowly And Dangle Their Feet Before Standing
3. Monitor Their Blood Pressure And Skip A Dose If The Pressure Is Less Than
120/80
4. Weigh Daily And Report Weight Gain Of Greater Than 2 Pounds In One Day
3. Monitor Their Blood Pressure And Skip A Dose If The Pressure Is Less Than
120/80
3. John Has Clonidine, A Centrally-Acting Adrenergic Blocker, Prescribed For
His Hypertension. He Should:
1. Not Miss A Dose Or Stop Taking The Drug Because Of Potential Rebound
Hypertension
2. Increase Fiber In The Diet To Treat Any Diarrhea That May Occur
3. Reduce Fluid Intake To Less Than 2 Liters Per Day To Prevent Fluid
Retention
4. Avoid Sitting For Long Periods, As This Can Lead To Deep Vein Thrombosis
1. Not Miss A Dose Or Stop Taking The Drug Because Of Potential Rebound
Hypertension
4. Clonidine Has Several Off-Label Uses, Including:
1. Alcohol And Nicotine Withdrawal
2. Post-Herpetic Neuralgia
3. Both 1 And 2
4. Neither 1 Nor 2
, 3. Both 1 And 2
5. Jim Is Being Treated For Hypertension. Because He Has A History Of Heart
Attacks, The Drug Chosen Is Atenolol. Beta-Blockers Treat Hypertension By:
1. Increasing Heart Rate To Improve Cardiac Output
2. Reducing Vascular Smooth Muscle Tone
3. Increasing Aldosterone-Mediated Volume Activity
4. Reducing Aqueous Humor Production
2. Reducing Vascular Smooth Muscle Tone
6. Which Of The Following Adverse Effects Are Less Likely In A Beta 1-Selective
Blocker?
1. Dysrhythmias
2. Impaired Insulin Release
3. Reflex Orthostatic Changes
4. Decreased Triglycerides And Cholesterol
2 . Impaired insulin release
7. Richard Is 70 Years Old And Has A History Of Cardiac Dysrhythmias. He Has
Been Prescribed Nadolol. You Do His Annual Laboratory Work And Find A
Crcl Of 25 Ml/Min. What Action Should You Take Related To His Nadolol?
1. Extend The Dosage Interval.
2. Decrease The Dose By 75%.
3. Take No Action Because This Value Is Expected In The Older Adult.
4. Schedule A Serum Creatinine Level To Validate The Crcl Value.
1 . Extend the dosage interval.
8. Beta Blockers Are The Drugs Of Choice For Exertional Angina Because They:
1. Improve Myocardial Oxygen Supply By Vasodilating The Coronary Arteries 2.
Decrease Myocardial Oxygen Demand By Decreasing Heart Rate And
Vascular Resistance 3. Both 1 And 2
4. Neither 1 Nor 2
2. Decrease Myocardial Oxygen Demand By Decreasing Heart Rate And
Vascular Resistance
9. Adherence To Beta-Blocker Therapy May Be Affected By Their:
, 1. Short Half-Lives Requiring Twice Daily Dosing
2. Tendency To Elevate Lipid Levels
3. Effects On The Male Genitalia, Which May Produce Impotence
4. None Of The Above
3. Effects On The Male Genitalia, Which May Produce Impotence
10. Beta-Blockers Have Favorable Effects On Survival And Disease Progression
In Heart Failure. Treatment Should Be Initiated When The:
1. Symptoms Are Severe
2. Patient Has Not Responded To Other Therapies
3. Patient Has Concurrent Hypertension
4. Left Ventricular Dysfunction Is Diagnosed
4 . Left ventricular dysfunction is diagnosed
11. Abrupt Withdrawal Of Beta Blockers Can Be Life-Threatening. Patients At The
Highest Risk For Serious Consequences Of Rapid Withdrawal Are Those
With:
1. Angina
2. Coronary Artery Disease
3. Both 1 And 2
4. Neither 1 Nor 2
3 . Both 1 and 2
12. To Prevent Life-Threatening Events From Rapid Withdrawal Of A Beta
Blocker:
1. The Dosage Interval Should Be Increased By 1 Hour Each Day.
2. An Alpha Blocker Should Be Added To The Treatment Regimen Before
Withdrawal.
3. The Dosage Should Be Tapered Over A Period Of Weeks.
4. The Dosage Should Be Decreased By One-Half Every 4 Days.
4. The Dosage Should Be Decreased By One-Half Every 4 Days.
13. Beta-Blockers Are Prescribed For Diabetics With Caution Because Of Their
Ability To Produce Hypoglycemia And Block The Common Symptoms Of It.
Which Of The Following Symptoms Of Hypoglycemia Is Not Blocked By These
Drugs And So Can Be Used To Warn Diabetics Of Possible Decreased Blood
Glucose?
, 1. Dizziness
2. Increased Heart Rate
3. Nervousness And Shakiness
4. Diaphoresis
4. Diaphoresis
14. Combined Alpha-Beta Antagonists Are Used To Reduce The Progression Of
Heart Failure Because They:
1. Vasodilate The Peripheral Vasculature
2. Decrease Cardiac Output
3. Increase Renal Vascular Resistance
4. Reduce Atherosclerosis Secondary To Elevated Serum Lipoproteins
1. Vasodilate The Peripheral Vasculature
15. Carvedilol Is Heavily Metabolized By Cyp2d6 And 2c9, Resulting In Drug
Interactions With Which Of The Following Drug Classes?
1. Histamine 2 Blockers
2. Quinolones
3. Serotonin Re-Uptake Inhibitors
4. All Of The Above
4 . All of the above
16. Alpha-Beta Blockers Are Especially Effective In Treating Hypertension For
Which Ethnic Group?
1. White
2. Asian
3. African American
4. Native American
3. African American
17. Bethanechol:
1. Increases Detrusor Muscle Tone To Empty The Bladder
2. Decreases Gastric Acid Secretion To Treat Peptic Ulcer Disease
3. Stimulates Voluntary Muscle Tone To Improve Strength
4. Reduces Bronchial Airway Constriction To Treat Asthma
1. Increases Detrusor Muscle Tone To Empty The Bladder
