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Fractionation Schedules - Answer- Standard
Hyper fractionation
Hypo fractionation
Accelerated Fractionation
Standard fractionation - Answer- daily single doses typically between 1.8-2.0 Gy per
day, delivered 5 days per week
Hyper fractionation - Answer- - smaller than standard doses
- Given more than once daily (separated by at least 6 hours)
- done over the standard treatment time
- allows increased dose delivery
- reduces late complication
Hypo fractionation - Answer- - use of larger daily doses, which
- less total dose over a shorter treatment time
- allows treatment over a shorter period of time;
- increased risk of late toxicity
Accelerated fractionation - Answer- Standard doses are given more than once daily
over a shortened treatment time (minimizes tumor cell repopulation)
Radio sensitizing chemotherapeutic agents include: - Answer- - Mitomycin
- Cisplatin
- Vinorelbine
- Paclitaxel
- Docetaxel
- 5FU
Radio protectors such as amifostine and dexrazoxane. - Answer- protect cells that are
well oxygenated, such as normal cells, but do not have much effect on hypoxic cells,
such as tumor cells
Low dose radiation (LDR) - Answer- continuous treatment administered over several
hours or days in a protected lead shielded room
High dose radiation (HDR) - Answer- source used rapidly deposits energy and
treatment may be given over a few minutes in either one or several doses (at least six
hours apart)