Science Biology Immunology
Chamberlain NR507 Midterm Exam
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Chamberlain NR507 Midterm Exam NR 507 midterm NP235 Immune and
63 terms 180 terms 72 terms
Lydia_Kimani5 Preview LivNichols923 Preview kuriachrisyuis
- "Allergic reaction"
- Mediated by IgE.
- Inflammation d/t mast cell degranulation.
- Hay fever, hives (uticaria).
Type 1 Hypersensitivity Reaction - Local s/s: itching, rash.
- Systemic: wheezing.
- Severe, systemic reaction: anaphylaxis: hypotension, severe
bronchoconstriction.
- Main tx: epinephrine.
- Cytotoxic reaction; tissue specific
- Macrophages are the primary effectors cells involved
- Causes tissue damage or alters function
- Examples: 1) Grave's disease- example of altering thyroid
Type 2 Hypersensitivity Reaction
function, doesn't destroy thyroid tissue. 2) ABO incompatibility-
example of cell/tissue damage; severe transfusion reaction
occurs & the transfused erythrocytes are destroyed by
agglutination or complement-mediated lysis.
- Type 2: organ specific; antibody binds to the antigen on the cell
surface.
Difference between type 2 & 3
- Type 3: not organ specific; antibody binds to soluble antigen
hypersensitivity reactions
outside the cell surface that was released into the blood or body
fluids, and the complex is then deposited in the tissues.
- Immune complex
- Antigen-antibody complex deposited in the tissues
- Neutrophils are the primary effector cell
Type 3 Hypersensitivity Reaction
- Causes autoimmune diseases
- Examples: rheumatoid arthritis ( joints), systemic lupus
erythematosus (SLE, organs)
, - Facial rash confined to the cheeks (malar rash)
- Discoid rash (raised patches, scaling)
- Photosensitivity (skin rash d/t sunlight exposure)
- Oral or nasopharyngeal ulcers
- Hematologic disorders (hemolytic anemia, leukopenia,
Systemic Lupus Erythematosus lymphopenia, thrombocytopenia)
(SLE) - Immunologic disorders
- Non-erosive arthritis of at least two peripheral joints
- Serositis (pleurisy, pericarditis)
- Renal disorder
- Neurologic disorders (seizures, psychosis)
- Presence of antinuclear antibody (ANA)
- Can be familial: Affected family members may not all develop
the same disease, but several members may have different
Autoimmunity
disorders characterized by a variety of hypersensitivity reactions
(autoimmune and allergic reactions).
- General term used to describe when an individual's immune
system reacts against antigens on the tissues of other members
of the same species.
Alloimmunity
- Examples: Neonatal disease where the maternal immune
system becomes sensitized against antigens expressed by the
fetus, Transplant rejection, Transfusion reaction.
- T-cell mediated
- Lymphocytes
- Does not involve antigen/antibody complexes
Type 4 Hypersensitivity
- Delayed response
Reaction
- Ex: localized contact dermatitis. Treated with a topical
corticosteroid (wouldn't use antihistamine since Type 4 doesn't
involve mast cells and H1 receptors).
- Type 1: Immediate hypersensitivity reactions, termed atopic
dermatitis, are usually characterized by widely distributed
lesions.
- Type 4: Contact dermatitis (delayed hypersensitivity) consists of
Differentiating between the rash lesions only at the site of contact with the allergen.
of a Type 1 vs Type 4 Reaction
The key determinant is the timing of the rash:
-Type 1 = Immediate
-Type 4 = Delayed: Several days following contact, ex- poison
ivy
- Most are the result of single gene defects.
- Occurs d/t immune system development defect.
- Antibody deficiencies, B- and T-cell deficiencies, phagocytic
Primary Immunodeficiency
cell defects, complement deficiency
- Ex: chronic granulomatous disease, familial Mediterranean
fever, common variable immunodeficiency
- Complication of some other physiologic condition or disease.
Secondary Immunodeficiency - Malnutrition is one of the most common causes worldwide.
- Cancer, drugs, chemotherapeutic agents.
Most of our body's iron stores The recycling of iron from old red blood cells (RBCs)
come from.....
Chamberlain NR507 Midterm Exam
Save
Students also studied
Flashcard sets Study guides
Chamberlain NR507 Midterm Exam NR 507 midterm NP235 Immune and
63 terms 180 terms 72 terms
Lydia_Kimani5 Preview LivNichols923 Preview kuriachrisyuis
- "Allergic reaction"
- Mediated by IgE.
- Inflammation d/t mast cell degranulation.
- Hay fever, hives (uticaria).
Type 1 Hypersensitivity Reaction - Local s/s: itching, rash.
- Systemic: wheezing.
- Severe, systemic reaction: anaphylaxis: hypotension, severe
bronchoconstriction.
- Main tx: epinephrine.
- Cytotoxic reaction; tissue specific
- Macrophages are the primary effectors cells involved
- Causes tissue damage or alters function
- Examples: 1) Grave's disease- example of altering thyroid
Type 2 Hypersensitivity Reaction
function, doesn't destroy thyroid tissue. 2) ABO incompatibility-
example of cell/tissue damage; severe transfusion reaction
occurs & the transfused erythrocytes are destroyed by
agglutination or complement-mediated lysis.
- Type 2: organ specific; antibody binds to the antigen on the cell
surface.
Difference between type 2 & 3
- Type 3: not organ specific; antibody binds to soluble antigen
hypersensitivity reactions
outside the cell surface that was released into the blood or body
fluids, and the complex is then deposited in the tissues.
- Immune complex
- Antigen-antibody complex deposited in the tissues
- Neutrophils are the primary effector cell
Type 3 Hypersensitivity Reaction
- Causes autoimmune diseases
- Examples: rheumatoid arthritis ( joints), systemic lupus
erythematosus (SLE, organs)
, - Facial rash confined to the cheeks (malar rash)
- Discoid rash (raised patches, scaling)
- Photosensitivity (skin rash d/t sunlight exposure)
- Oral or nasopharyngeal ulcers
- Hematologic disorders (hemolytic anemia, leukopenia,
Systemic Lupus Erythematosus lymphopenia, thrombocytopenia)
(SLE) - Immunologic disorders
- Non-erosive arthritis of at least two peripheral joints
- Serositis (pleurisy, pericarditis)
- Renal disorder
- Neurologic disorders (seizures, psychosis)
- Presence of antinuclear antibody (ANA)
- Can be familial: Affected family members may not all develop
the same disease, but several members may have different
Autoimmunity
disorders characterized by a variety of hypersensitivity reactions
(autoimmune and allergic reactions).
- General term used to describe when an individual's immune
system reacts against antigens on the tissues of other members
of the same species.
Alloimmunity
- Examples: Neonatal disease where the maternal immune
system becomes sensitized against antigens expressed by the
fetus, Transplant rejection, Transfusion reaction.
- T-cell mediated
- Lymphocytes
- Does not involve antigen/antibody complexes
Type 4 Hypersensitivity
- Delayed response
Reaction
- Ex: localized contact dermatitis. Treated with a topical
corticosteroid (wouldn't use antihistamine since Type 4 doesn't
involve mast cells and H1 receptors).
- Type 1: Immediate hypersensitivity reactions, termed atopic
dermatitis, are usually characterized by widely distributed
lesions.
- Type 4: Contact dermatitis (delayed hypersensitivity) consists of
Differentiating between the rash lesions only at the site of contact with the allergen.
of a Type 1 vs Type 4 Reaction
The key determinant is the timing of the rash:
-Type 1 = Immediate
-Type 4 = Delayed: Several days following contact, ex- poison
ivy
- Most are the result of single gene defects.
- Occurs d/t immune system development defect.
- Antibody deficiencies, B- and T-cell deficiencies, phagocytic
Primary Immunodeficiency
cell defects, complement deficiency
- Ex: chronic granulomatous disease, familial Mediterranean
fever, common variable immunodeficiency
- Complication of some other physiologic condition or disease.
Secondary Immunodeficiency - Malnutrition is one of the most common causes worldwide.
- Cancer, drugs, chemotherapeutic agents.
Most of our body's iron stores The recycling of iron from old red blood cells (RBCs)
come from.....
