NU664C Study Guide for Midterm Exam
2025/2026 Exam Questions and Verified
Answers | Already Graded A+
Know the route of administration for newer agent asenapine (Saphris) and what
instructions should be given to the patient regarding administration. - 🧠 ANSWER
✔✔Route- Sublingual
Not to eat or drink for 10 minutes after medication administration
Not to swallow or chew the capsule.
Asenapine is an atypical antipsychotic (serotonin-dopamine antagonist, as a mood
stabilizer). Asenapine is not absorbed after swallowing (less than 2% bioavailable
orally) and thus must be administered sublingually (35% bioavailable), as
swallowing would render asenapine inactive.
,Patients should be instructed to place the tablet under the tongue and allow it to
dissolve completely, which will occur in seconds; tablet should not be divided,
crushed, chewed, or swallowed.
Patients may not eat or drink for 10 minutes following sublingual administration so
that the drug in the oral cavity can be absorbed locally and not washed into the
stomach (where it would not be absorbed).
Due to rapid onset of action, can be used as a rapid acting "prn" or "as needed"
dose for agitation or transient worsening of psychosis or mania instead of an
injection.
Treatment should be suspended if absolute neutrophil count falls below
1,000/mm3.
Know and describe the top atypical antipsychotic with greatest incidence of
prolonged QTc interval. - 🧠 ANSWER ✔✔Ziprasidone (Geodon).
Normal QTc =450.
>470, Call Cardiologist
>500, stop all meds.
Ziprasidone (Geodon) has been associated with a dose-related prolongation of the
QTc
COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
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STATEMENT. ALL RIGHTS RESERVED
, QTc interval prolongation is greatest with ziprasidone and least with olanzapine.
Ziprasidone (Geodon) an atypical antipsychotic (serotonin-dopamine antagonist;
second-generation antipsychotic; also a mood stabilizer.
Ziprasidone is prescribed for Schizophrenia, delaying relapse in schizophrenia,
acute agitation in schizophrenia (intramuscular), acute mania/mixed mania, bipolar
maintenance, other psychotic d/o, bipolar depression, behavioral disturbances in
dementias, behavioral disturbances in children and adolescents, and disorders
associated with problems with impulse control.
Ziprasidone blocks dopamine 2 receptors, reducing positive symptoms of
psychosis and stabilizing affective symptoms. Blocks serotonin 2A receptors,
causing enhancement of dopamine release in certain brain regions and thus
reducing motor side effects and possible improving cognitive and affective
symptoms.
EKGs may be useful for selected patients (e.g., those with personal or family
history of QTc prolongation; cardiac arrhythmia; recent myocardial infarction;
uncompensated heart failure; or those taking agents that prolong QTc interval
(such as pimozide, thioridazine, selected antiarrhythmics, moxifloxacin,
sparfloxacin, etc.)
Ziprasidone prolongs QTc interval more than some other antipsychotics.
COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
3
STATEMENT. ALL RIGHTS RESERVED
2025/2026 Exam Questions and Verified
Answers | Already Graded A+
Know the route of administration for newer agent asenapine (Saphris) and what
instructions should be given to the patient regarding administration. - 🧠 ANSWER
✔✔Route- Sublingual
Not to eat or drink for 10 minutes after medication administration
Not to swallow or chew the capsule.
Asenapine is an atypical antipsychotic (serotonin-dopamine antagonist, as a mood
stabilizer). Asenapine is not absorbed after swallowing (less than 2% bioavailable
orally) and thus must be administered sublingually (35% bioavailable), as
swallowing would render asenapine inactive.
,Patients should be instructed to place the tablet under the tongue and allow it to
dissolve completely, which will occur in seconds; tablet should not be divided,
crushed, chewed, or swallowed.
Patients may not eat or drink for 10 minutes following sublingual administration so
that the drug in the oral cavity can be absorbed locally and not washed into the
stomach (where it would not be absorbed).
Due to rapid onset of action, can be used as a rapid acting "prn" or "as needed"
dose for agitation or transient worsening of psychosis or mania instead of an
injection.
Treatment should be suspended if absolute neutrophil count falls below
1,000/mm3.
Know and describe the top atypical antipsychotic with greatest incidence of
prolonged QTc interval. - 🧠 ANSWER ✔✔Ziprasidone (Geodon).
Normal QTc =450.
>470, Call Cardiologist
>500, stop all meds.
Ziprasidone (Geodon) has been associated with a dose-related prolongation of the
QTc
COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
2
STATEMENT. ALL RIGHTS RESERVED
, QTc interval prolongation is greatest with ziprasidone and least with olanzapine.
Ziprasidone (Geodon) an atypical antipsychotic (serotonin-dopamine antagonist;
second-generation antipsychotic; also a mood stabilizer.
Ziprasidone is prescribed for Schizophrenia, delaying relapse in schizophrenia,
acute agitation in schizophrenia (intramuscular), acute mania/mixed mania, bipolar
maintenance, other psychotic d/o, bipolar depression, behavioral disturbances in
dementias, behavioral disturbances in children and adolescents, and disorders
associated with problems with impulse control.
Ziprasidone blocks dopamine 2 receptors, reducing positive symptoms of
psychosis and stabilizing affective symptoms. Blocks serotonin 2A receptors,
causing enhancement of dopamine release in certain brain regions and thus
reducing motor side effects and possible improving cognitive and affective
symptoms.
EKGs may be useful for selected patients (e.g., those with personal or family
history of QTc prolongation; cardiac arrhythmia; recent myocardial infarction;
uncompensated heart failure; or those taking agents that prolong QTc interval
(such as pimozide, thioridazine, selected antiarrhythmics, moxifloxacin,
sparfloxacin, etc.)
Ziprasidone prolongs QTc interval more than some other antipsychotics.
COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
3
STATEMENT. ALL RIGHTS RESERVED
