GMS 6540 EXAMINATION TEST 2025/2026 QUESTIONS WITH SOLUTIONS RATED A+

GMS 6540 EXAMINATION TEST 2025/2026 QUESTIONS
WITH SOLUTIONS RATED A+
✔✔What is the target of pembrolizumab?

PD-L1 on cancer cells
PD-L1 on T-cells
PD-1 on cancer cells
PD-1 on T-cells - ✔✔PD-1 on T-cells

✔✔Which cells will CTL019 kill? Select all that apply.

Cancer cells lacking CD19
Cancer cells expressing CD19
Normal cells lacking CD19
Normal cells expressing CD19 - ✔✔Cancer cells expressing CD19
Normal cells expressing CD19

✔✔What is the process called when two EGFR proteins bind to each other?

Conjugation
Combination
Colocalization
Dimerization
Translocation - ✔✔Dimerization

✔✔In what location does Cetuximab bind EGFR?

Extracellularly
Intramembranously
Intracellularly
Intranuclearly - ✔✔Extracellularly

✔✔Which type of immune cells induce ADCC in cells treated with Cetuximab?

B cells
Plasma cells
Granulocytes
Natural killer cells
Monocytes - ✔✔Natural killer cells

✔✔If a patient is being treated with Osimertinib, what were they likely treated with
previously?

Cetuximab

, Erlotinib
Trastuzumab
Lapatinib
Imatinib - ✔✔Erlotinib

✔✔What is the endogenous ligand for HER2?

EGF
Neu
PDGF
HGF
It has no known ligand. - ✔✔It has no known ligand

✔✔A breast cancer patient with a tumor with which characterization would be most
likely to respond to Tamoxifen?

ER- PR+ HER2+
ER- PR+ HER2-
ER- PR- HER2-
ER+ PR+ HER2+
ER+ PR- HER2- - ✔✔ER+ PR- HER2-

✔✔Which class of drugs could potentially increase estrogen signaling?

SERMs
SERDs
AIs - ✔✔SERMs

✔✔Which drug significantly increases the risk of DVTs?

Tamoxifen
Raloxifene
Fulvestrant
Anastrozole
Exemastane - ✔✔Raloxifene

✔✔Which drug is given intramuscularly?

Tamoxifen
Raloxifene
Fulvestrant
Anastrozole
Exemastane - ✔✔Fulvestrant

✔✔Enzalutamide blocks the signaling caused by which hormone?