LOMA 335 The Insurance Company and Operations Management (Module 2) exam with answers

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Exam (elaborations)

LOMA 335 The Insurance Company and Operations Management (Module 2) exam with answers

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23 pages

2024/2025

Institution LOMA 335

Course LOMA 335

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LOMA 335 The Insurance Company and Operations Management (Module 2) exam with answers

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GMS 6552 Exam 1 with !| !| !| !| !|

verified detailed solutions !| !|

Molecular Drug Targets - Correct answer ✔Receptors-45%
!| !| !| !| !| !|

Enzymes-28%

Hormones-11%

Unknown-7%

Ion Channels-5%
!|

DNA-4%

Channel-Linked (Ionotropic) Receptors - Correct answer ✔Produce
!| !| !| !| !| !| !|

cellular effects in milliseconds
!| !| !|

Nicotinic ACh receptor !| !|

GPCRs - Correct answer ✔Effects happen in seconds
!| !| !| !| !| !| !|

Muscarinic ACh receptor !| !|

Kinase-linked receptors - Correct answer ✔Effects happen in minutes
!| !| !| !| !| !| !| !|

Insulin receptor
!|

Receptors linked to gene transcription - Correct answer ✔Effects happen
!| !| !| !| !| !| !| !| !| !|

in hours
!|

,Estrogen receptor !|

Heterotrimeric G proteins - Correct answer ✔alpha, beta and gamma !| !| !| !| !| !| !| !| !| !|

subunits

GPCR Components - Correct answer ✔More than 800 receptors
!| !| !| !| !| !| !| !|

7 transmembrane domains
!| !|

N and C termini
!| !| !|

Conformationally flexible !|

Constitutively active !|

GPCR Ligands - Correct answer ✔Hormones, neurotransmitters,
!| !| !| !| !| !| !|

chemokine, ions, amino acids, peptides !| !| !| !|

G-proteins - Correct answer ✔a-20 !| !| !| !|

Gas- increases AC !| !|

Gai - decreases AC
!| !| !|

Gaq - increases PLC
!| !| !|

b(6)y(12)

Why use G proteins - Correct answer ✔Means of amplifying the signal
!| !| !| !| !| !| !| !| !| !| !|

G proteins can regulate more than one effector
!| !| !| !| !| !| !|

, PKA - Correct answer ✔Phosphorylase Kinase (glycogen breakdown)
!| !| !| !| !| !| !|

CREB (gene transcription)
!| !|

L-type Ca channels (heart contraction)
!| !| !| !|

Pyruvate Kinase (glycolysis) !| !|

Hormone Sensitive Lipase (triglyceride breakdown)
!| !| !| !|

Kinase-linked receptor signaling - Correct answer ✔No second messenger
!| !| !| !| !| !| !| !|

Protein kinase-linked receptors - Correct answer ✔Receptors associated
!| !| !| !| !| !| !| !|

with cytosolic kinases
!| !|

Receptor tyrosine kinases !| !|

Receptor serine/threonine kinases
!| !|

Receptors associated with cytosolic kinases - Correct answer ✔Ligands:
!| !| !| !| !| !| !| !|

Prolactin

GH

Interferons

Cytokines

Receptor tyrosine kinases - Correct answer ✔Receptor tyrosine kinases
!| !| !| !| !| !| !| !| !|

(RTKs) consist of an extracellular ligand
!| !| !| !| !|

binding and dimerization domain, a single hydrophobic
!| !| !| !| !| !|

transmembrane a-helix and a cytosolic domain with intrinsic
!| !| !| !| !| !| !|

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Uploaded on: July 25, 2025
Number of pages: 23
Written in: 2024/2025
Type: Exam (elaborations)
Contains: Questions & answers

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