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GMS 6552 Exam 2 with verified detailed answers

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Exam (elaborations)

GMS 6552 Exam 2 with verified detailed answers

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Institution GMS 6552

Course GMS 6552

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GMS 6552 Exam 2 with verified detailed answers

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GMS 6552 Exam 2 with !| !| !| !| !|

verified detailed !| !|

answers

An oncogene is defined as - Correct answer ✔a gene that causes or
!| !| !| !| !| !| !| !| !| !| !| !| !|

contributes to the development of cancer
!| !| !| !| !|

What are the two types of evidence for oncogenic behavior? - Correct
!| !| !| !| !| !| !| !| !| !| !| !|

answer ✔In vivo !| !|

In vitro
!|

What are the 4 criteria for In vivo oncogenic behavior - Correct answer
!| !| !| !| !| !| !| !| !| !| !| !| !|

✔Cause cancer when activated in a transgenic animal
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Render nontumorigenic cells tumorigenic
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Knock down or knock out in tumorigenic cells renders the cells
!| !| !| !| !| !| !| !| !| !| !|

nontumorigenic !|

Activation/overexpression of the oncogene is strongly correlated with !| !| !| !| !| !| !| !|

human cancer !|

, What are the 3 criteria for In vitro oncogenic behavior - Correct answer
!| !| !| !| !| !| !| !| !| !| !| !| !|

✔Causes anchorage-independent growth in soft agar (protection from
!| !| !| !| !| !| !| !|

anoikis) !|

Causes focus formation (loss of contact inhibition)
!| !| !| !| !| !| !|

Renders cells growth factor independent
!| !| !| !|

What is an example of a GTPase that plays a biochemical role in
!| !| !| !| !| !| !| !| !| !| !| !| !|

oncogenes. - Correct answer ✔Ras !| !| !| !|

What is an example of a Protein Kinases that plays a biochemical role in
!| !| !| !| !| !| !| !| !| !| !| !| !| !|

oncogenes. - Correct answer ✔Raf, Akt, BCR-ABL, Cdk4, Src
!| !| !| !| !| !| !| !|

What is an example of a Lipid Kinases that plays a biochemical role in
!| !| !| !| !| !| !| !| !| !| !| !| !| !|

oncogenes. - Correct answer ✔PI3-Kinase !| !| !| !|

What is an example of a Transcription factors that plays a biochemical
!| !| !| !| !| !| !| !| !| !| !| !|

role in oncogenes. - Correct answer ✔Myc, Fos, Jun, E2F1, ....
!| !| !| !| !| !| !| !| !| !|

What is an example of a Binding and inactivating apoptotic proteins that
!| !| !| !| !| !| !| !| !| !| !| !|

plays a biochemical role in oncogenes. - Correct answer ✔BCL2
!| !| !| !| !| !| !| !| !|

What is an example of a Protein Kinase Regulatory Subunits that plays a
!| !| !| !| !| !| !| !| !| !| !| !| !|

biochemical role in oncogenes. - Correct answer ✔Cyclins A, E, and D
!| !| !| !| !| !| !| !| !| !| !|

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Uploaded on: July 25, 2025
Number of pages: 15
Written in: 2024/2025
Type: Exam (elaborations)
Contains: Questions & answers

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