Pharma - Midterms - Quiz 2 Questions and Answers Already Passed
Drug Delivery Systems - AnswersRate controlled; continuously deliver small amounts of drug to a
specific target site
True - AnswersRelease of the drug inside the patient's body strictly controlled by the device or design of
the drug. True or False
True - AnswersRelease of drug is prolonged because it's gradually released. True or False
1. Decrease in side effects because drug is
delivered directly
2. Eliminates peaks and valleys of periodic dosing
3. Improve drug performance
4. Better Patient Compliance - AnswersAdvantages of DDS
Transdermal Patches - AnswersRefer as "skin patches"
Liner
Drug
Membrane
Adhesive
Backing - Answers5 Layers of Transdermal Patches
Nicotine Patches - AnswersA smoker who is trying to quit may wear this. Produce a static effect when
they try to smoke as a way of withdrawal
Analgesic Patches - AnswersMore common patches, such as Salonpas
The PassPort System - AnswersRelease of drug through that very thin layer of patch is
activated by an RF system
Oral Osmotic Pumps - AnswersOrally administered oversized capsule that needs to be swallowed by the
patient. Capsule made out of 2 semipermeable membranes which do not easily dissolved in stomach
acid and small intestine.
Reduced dose
targeting of site
, avoiding GI stability
hepatic bypass of drug molecule - AnswersAdvantage of Oral Osmotic Pumps
- AnswersUnlike Traditional capsules, Oral Osmotic Pumps:
○ Capsule does not really dissolve or if it
dissolves, only at the latter part (elimination)
○ Capsule shell quickly dissolves
Semi Permeable Membrane - AnswersPart of Oras Osmotic Pumps that Allows lumen from the stomach
and intestine to get inside the chamber which is in the middle.
Implantable Pumps - AnswersImplantable — inside patient body; These days, implants being passed
onto the patients which are controlled by radiofrequency (RF)
Insulin Pump - AnswersExample of Implantable Pump
INJECTABLE drug Carriers - AnswersDrugs that are in a nano level; Injected to the body then spread
within the body; nano-suspension particulate delivery system; Colloidal drug carrier systems such as
micellar solutions, vesicle and liquid crystal dispersions.
True - AnswersDrug molecules need to get in a circulation except for
intravenous administration. True or False
40% - AnswersLipid Component of the Bilayer
5-10% - AnswersCarbohydrate Component of The Bilayer
50-60% - AnswersProtein Component of the Bilayer
Phospholipid Bilayer - AnswersA double layer of phospholipids that makes up plasma and organelle
membranes.
Fluid Mosaic Model - AnswersStructural model of the plasma membrane where molecules are free to
move sideways within a lipid bilayer.
Glycolipids - AnswersMembrane carbohydrates that are covalently bonded to lipids.
Glycoproteins - AnswersMembrane carbohydrates that are covalently bonded to proteins.
Passive Transfer - AnswersLipid-soluble substances use simple diffusion to move across lipoprotein
membrane; Water-soluble molecules (small) can pass through membranes via bulk flow of water;
Filtration of molecules may also be included.
Simple Diffusion
Drug Delivery Systems - AnswersRate controlled; continuously deliver small amounts of drug to a
specific target site
True - AnswersRelease of the drug inside the patient's body strictly controlled by the device or design of
the drug. True or False
True - AnswersRelease of drug is prolonged because it's gradually released. True or False
1. Decrease in side effects because drug is
delivered directly
2. Eliminates peaks and valleys of periodic dosing
3. Improve drug performance
4. Better Patient Compliance - AnswersAdvantages of DDS
Transdermal Patches - AnswersRefer as "skin patches"
Liner
Drug
Membrane
Adhesive
Backing - Answers5 Layers of Transdermal Patches
Nicotine Patches - AnswersA smoker who is trying to quit may wear this. Produce a static effect when
they try to smoke as a way of withdrawal
Analgesic Patches - AnswersMore common patches, such as Salonpas
The PassPort System - AnswersRelease of drug through that very thin layer of patch is
activated by an RF system
Oral Osmotic Pumps - AnswersOrally administered oversized capsule that needs to be swallowed by the
patient. Capsule made out of 2 semipermeable membranes which do not easily dissolved in stomach
acid and small intestine.
Reduced dose
targeting of site
, avoiding GI stability
hepatic bypass of drug molecule - AnswersAdvantage of Oral Osmotic Pumps
- AnswersUnlike Traditional capsules, Oral Osmotic Pumps:
○ Capsule does not really dissolve or if it
dissolves, only at the latter part (elimination)
○ Capsule shell quickly dissolves
Semi Permeable Membrane - AnswersPart of Oras Osmotic Pumps that Allows lumen from the stomach
and intestine to get inside the chamber which is in the middle.
Implantable Pumps - AnswersImplantable — inside patient body; These days, implants being passed
onto the patients which are controlled by radiofrequency (RF)
Insulin Pump - AnswersExample of Implantable Pump
INJECTABLE drug Carriers - AnswersDrugs that are in a nano level; Injected to the body then spread
within the body; nano-suspension particulate delivery system; Colloidal drug carrier systems such as
micellar solutions, vesicle and liquid crystal dispersions.
True - AnswersDrug molecules need to get in a circulation except for
intravenous administration. True or False
40% - AnswersLipid Component of the Bilayer
5-10% - AnswersCarbohydrate Component of The Bilayer
50-60% - AnswersProtein Component of the Bilayer
Phospholipid Bilayer - AnswersA double layer of phospholipids that makes up plasma and organelle
membranes.
Fluid Mosaic Model - AnswersStructural model of the plasma membrane where molecules are free to
move sideways within a lipid bilayer.
Glycolipids - AnswersMembrane carbohydrates that are covalently bonded to lipids.
Glycoproteins - AnswersMembrane carbohydrates that are covalently bonded to proteins.
Passive Transfer - AnswersLipid-soluble substances use simple diffusion to move across lipoprotein
membrane; Water-soluble molecules (small) can pass through membranes via bulk flow of water;
Filtration of molecules may also be included.
Simple Diffusion
