Pharmacotherapeutics for Advanced Practice Nurse Prescribers –
Course Summary and Study Guide
Nurse practitioner prescriptive authority is regulated by who? The State Board of Nursing for Each State
<< correct answer >>What is the benefits of having an APRN prescriber? APRN's care for patients more
holistically and include patients in making decisions regarding their care << correct answer >>What does
clinical judgement in prescribing include? Factoring in the cost of the particular << correct answer
>>What is included in the criteria for choosing and effective drug for a disorder? Consulting nationally
recognized guidelines for disease management << correct answer >>NP's thrive under the new health-
care reform because of what? NP's have the ability to control care cost and improve patient outcome <<
correct answer >>Nutritional intake and lab results reflect hypoalbuminemia; why is this important for
prescribers? The Distribution of drugs to target tissues may be affected << correct answer >>Drugs that
have an significant first-pass effect what? they are rapidly metabolized by the liver and may have little if
any desired action << correct answer >>The route of excretion of a volatile drug will likely be? Lungs <<
correct answer >>Medroxyprogesterone (Depo Provera) is prescribed IM to create storage reservoir of
the drug. What are storage reserviors> Increased the length of time a drug is available and active <<
correct answer >>Why is Cephalexin given every 8 hours? What knowledge of the drug does the NP
know? Half Life << correct answer >>Azithromycin doing requires that the first day's doing be twice
those of the other four day; This is considered a loading does. What is a loading dose? Rapidly actives
drug levels in the therapeutic range << correct answer >>The point in time on the drug concentration
curve that indicates the first sign of a therapeutic effect is the: Onset of action << correct answer
>>Phenytoin required that a trough level be drawn. When and why are peak and trough levels are done
To determine if a d rug is in the therapeutic range << correct answer >>Drugs that are receptor agonists
may demonstrate what property? Concentrations will produce an adverse effect << correct answer
>>Factors that affect gastric drug absorption include Lipid solubility of the drug << correct answer
>>Drugs that are receptors antagonists, such as beta-blockers, may cause what? An exaggerated
response if abrupt discontinues << correct answer >>Drug administration via IV:
1) need to be lipid soluble in order to absorb easily
2) Begin distribution in the body immediately
3) Are easily absorbed if they are nonionized
4) May use pinocytosis to be absorbed Are easily absorbed if they are nonionized << correct answer
>>What is the combination effect when a medication is added to a regimen for a synergistic effect?
Greater than the sum of the effects of each drug individually << correct answer >>Which of the following
statements about bioavailability is true?
1) Bioavailability issues are especially important for drugs with narrow therapeutic
ranges or sustained-release mechanisms.
2) brands of a drug have the same bioavailability.
, 3) Drugs that are administered more than once a day have greater bioavailability than
drugs given once daily.
4) Combining an active drug with an inert substance does not affect bioavailability. Bioavailability issues
are especially important for drugs with narrow therapeutic << correct answer >>Which of the following
statements about the major distribution barriers (blood-brain or fetal-placental) is true?
1) Water soluble and ionized drugs cross these barriers rapidly.
2) The blood-brain barrier slows the entry of many drugs into and from brain cells.
3) The fetal-placental barrier protects the fetus from drugs taken by the mother.
4) Lipid-soluble drugs do not pass these barriers and are safe for pregnant women The blood-brain
barrier slows the entry of many drugs into and from brain cells. << correct answer >>What is the
purpose of phase I and phase II of metabolism in the liver? Change drug molecules to a form that an
excretory organ can excrete << correct answer >>What happens to the metabolites after they are
metabolized in the liver? the metabolite may or may not be more active than the parent drug and they
are totally deactivated so they are excreted without and effect; it depends on the medication being
given << correct answer >>What causes the body to increased the excretion of a drug through the renal
system Unbinding a nonvolatile drug from plasma proteins. << correct answer >>What is "steady state"?
When the amount of the drug in the body remains constant << correct answer >>When two pain
medications are given together to treat pain, what kind of drug-to-drug interaction occurs? Additive <<
correct answer >>Actions taken to reduce drug—drug interaction problems include all of the following
EXCEPT:
1) Reducing the dosage of one of the drugs
2) Scheduling their administration at different times
3) Prescribing a third drug to counteract the adverse reaction of the combination
4) Reducing the dosage of both drugs Prescribing a third drug to counteract the adverse reaction of the
combination << correct answer >>What reduces the inhibition properties of Phase 1 Oxidative reductive
process of drug metabolism? << correct answer >>What is the period of time called that it takes for a
drug too decreased by 50% in the body? Half Life << correct answer >>Drug antagonism is best defined
as an effect of a drug that:
1. Leads to major physiological and psychological dependence
2. Is modified by the concurrent administration of another drug
3. Cannot be metabolized before another dose is administered
4. Leads to a decreased physiological response when combined with another drug Is modified by the
concurrent administration of another drug << correct answer >>What happens when a drug antagonist
is given regularly? Down regulated the number of specific receptors << correct answer >>What should
be included in the education fo those who are prescribed oral enteric coated tables To achieve best
effect, take the tablet with at least 8 oz of fluids << correct answer >>What is the main reason for not
Course Summary and Study Guide
Nurse practitioner prescriptive authority is regulated by who? The State Board of Nursing for Each State
<< correct answer >>What is the benefits of having an APRN prescriber? APRN's care for patients more
holistically and include patients in making decisions regarding their care << correct answer >>What does
clinical judgement in prescribing include? Factoring in the cost of the particular << correct answer
>>What is included in the criteria for choosing and effective drug for a disorder? Consulting nationally
recognized guidelines for disease management << correct answer >>NP's thrive under the new health-
care reform because of what? NP's have the ability to control care cost and improve patient outcome <<
correct answer >>Nutritional intake and lab results reflect hypoalbuminemia; why is this important for
prescribers? The Distribution of drugs to target tissues may be affected << correct answer >>Drugs that
have an significant first-pass effect what? they are rapidly metabolized by the liver and may have little if
any desired action << correct answer >>The route of excretion of a volatile drug will likely be? Lungs <<
correct answer >>Medroxyprogesterone (Depo Provera) is prescribed IM to create storage reservoir of
the drug. What are storage reserviors> Increased the length of time a drug is available and active <<
correct answer >>Why is Cephalexin given every 8 hours? What knowledge of the drug does the NP
know? Half Life << correct answer >>Azithromycin doing requires that the first day's doing be twice
those of the other four day; This is considered a loading does. What is a loading dose? Rapidly actives
drug levels in the therapeutic range << correct answer >>The point in time on the drug concentration
curve that indicates the first sign of a therapeutic effect is the: Onset of action << correct answer
>>Phenytoin required that a trough level be drawn. When and why are peak and trough levels are done
To determine if a d rug is in the therapeutic range << correct answer >>Drugs that are receptor agonists
may demonstrate what property? Concentrations will produce an adverse effect << correct answer
>>Factors that affect gastric drug absorption include Lipid solubility of the drug << correct answer
>>Drugs that are receptors antagonists, such as beta-blockers, may cause what? An exaggerated
response if abrupt discontinues << correct answer >>Drug administration via IV:
1) need to be lipid soluble in order to absorb easily
2) Begin distribution in the body immediately
3) Are easily absorbed if they are nonionized
4) May use pinocytosis to be absorbed Are easily absorbed if they are nonionized << correct answer
>>What is the combination effect when a medication is added to a regimen for a synergistic effect?
Greater than the sum of the effects of each drug individually << correct answer >>Which of the following
statements about bioavailability is true?
1) Bioavailability issues are especially important for drugs with narrow therapeutic
ranges or sustained-release mechanisms.
2) brands of a drug have the same bioavailability.
, 3) Drugs that are administered more than once a day have greater bioavailability than
drugs given once daily.
4) Combining an active drug with an inert substance does not affect bioavailability. Bioavailability issues
are especially important for drugs with narrow therapeutic << correct answer >>Which of the following
statements about the major distribution barriers (blood-brain or fetal-placental) is true?
1) Water soluble and ionized drugs cross these barriers rapidly.
2) The blood-brain barrier slows the entry of many drugs into and from brain cells.
3) The fetal-placental barrier protects the fetus from drugs taken by the mother.
4) Lipid-soluble drugs do not pass these barriers and are safe for pregnant women The blood-brain
barrier slows the entry of many drugs into and from brain cells. << correct answer >>What is the
purpose of phase I and phase II of metabolism in the liver? Change drug molecules to a form that an
excretory organ can excrete << correct answer >>What happens to the metabolites after they are
metabolized in the liver? the metabolite may or may not be more active than the parent drug and they
are totally deactivated so they are excreted without and effect; it depends on the medication being
given << correct answer >>What causes the body to increased the excretion of a drug through the renal
system Unbinding a nonvolatile drug from plasma proteins. << correct answer >>What is "steady state"?
When the amount of the drug in the body remains constant << correct answer >>When two pain
medications are given together to treat pain, what kind of drug-to-drug interaction occurs? Additive <<
correct answer >>Actions taken to reduce drug—drug interaction problems include all of the following
EXCEPT:
1) Reducing the dosage of one of the drugs
2) Scheduling their administration at different times
3) Prescribing a third drug to counteract the adverse reaction of the combination
4) Reducing the dosage of both drugs Prescribing a third drug to counteract the adverse reaction of the
combination << correct answer >>What reduces the inhibition properties of Phase 1 Oxidative reductive
process of drug metabolism? << correct answer >>What is the period of time called that it takes for a
drug too decreased by 50% in the body? Half Life << correct answer >>Drug antagonism is best defined
as an effect of a drug that:
1. Leads to major physiological and psychological dependence
2. Is modified by the concurrent administration of another drug
3. Cannot be metabolized before another dose is administered
4. Leads to a decreased physiological response when combined with another drug Is modified by the
concurrent administration of another drug << correct answer >>What happens when a drug antagonist
is given regularly? Down regulated the number of specific receptors << correct answer >>What should
be included in the education fo those who are prescribed oral enteric coated tables To achieve best
effect, take the tablet with at least 8 oz of fluids << correct answer >>What is the main reason for not
