GOLDFRANK'S SELF-ASSESSMENT QUIZZES
ACTUAL LATEST EXAM 2025 WITH 160 QUESTIONS
AND VERIFIED CORRECT ANSWERS | ALREADY
GRADED A+ | GUARANTEED PASS | GOLDFRANK'S
SELF-ASSESSMENT QUIZZES
LATEST EXAM 2025 [BRAND NEW]
pancreatic alpha cell disruptors - ANSWER ✔✔- cobalt salts
decamethylene-diguanidine
phenylethylbiguanide
pancreatic beta cell disruptors - ANSWER ✔✔- cyproheptadine
pentamidine
streptozocin
vacor (pyrinuron)
adenosine receptors - ANSWER ✔✔- - cerebral and peripheral
vasculature
- stimulates vasodilation
- methylxanthines: antagonize the inhibitory effect of adenosine
(postsynaptic A1 receptors)
--> increased HR, increased ventilation, GI motility, gastric acid
secretion
1|Page
,- chronic caffeine: increases A1 receptors, increases receptor affinity,
enhances receptor coupling to the G protein, increased G protein
stimulated adenyl cyclase
colchicine: cycle of blood cell damage - ANSWER ✔✔- leukocytosis,
then
leukopenia (48-72 hours)
pancytopenia
then rebound
From: Folpini et al: Colchicine toxicity. JToxClinTox 1995;33:71-77
what GHB analog has a pharmacokinetic interaction with ethanol? -
ANSWER ✔✔- 1,4-butandediol (1,4-BD)
- 1,4-BD is metabolized by alcohol dehydrogenase, as is GHB
- coingestion can delay and prolong clinical effects
how is thujone toxic? - ANSWER ✔✔- GABA-A antagonism, in
absinthe
- antagonizes GABA-A receptor at the picrotoxin site on the chloride
channel
- effects: neuroexcitation (hallucinations or seizures)
zinc deficiency (3 features) - ANSWER ✔✔- 1. alopecia
2|Page
, 2. diarrhea
3. dermatitis
- either autosomal recessive or acquired
- TPN w/o zinc, intestinal bypass, Crohn's, preemies
aka acrodermatitis enteropathica
rapid acetylators and INH toxicity - ANSWER ✔✔- clinically: same risk
for hepatotoxicity, lower risk for neurotoxicity as normal acetylators
cadmium toxicity (3 cellular functions) - ANSWER ✔✔- 1. binding to
sulfhydryl groups (denaturing proteins and inactivating enzymes)
2. interference with cell-cell adhesion (cadherins E &N, and B-catenin)
3. interference with calcium transport mechanisms
vitamin A induced hepatotoxicity - ANSWER ✔✔- cirrhosis:
proliferative effect on Ito cells, depositing excessive collagen and
causing liver scarring
how does lead cause anemia? - ANSWER ✔✔- decreased hemoglobin
synthesis
other effects: increased production of RBCs and increased release of
reticulocytes to compensate for decreased hgb synthesis
3|Page
ACTUAL LATEST EXAM 2025 WITH 160 QUESTIONS
AND VERIFIED CORRECT ANSWERS | ALREADY
GRADED A+ | GUARANTEED PASS | GOLDFRANK'S
SELF-ASSESSMENT QUIZZES
LATEST EXAM 2025 [BRAND NEW]
pancreatic alpha cell disruptors - ANSWER ✔✔- cobalt salts
decamethylene-diguanidine
phenylethylbiguanide
pancreatic beta cell disruptors - ANSWER ✔✔- cyproheptadine
pentamidine
streptozocin
vacor (pyrinuron)
adenosine receptors - ANSWER ✔✔- - cerebral and peripheral
vasculature
- stimulates vasodilation
- methylxanthines: antagonize the inhibitory effect of adenosine
(postsynaptic A1 receptors)
--> increased HR, increased ventilation, GI motility, gastric acid
secretion
1|Page
,- chronic caffeine: increases A1 receptors, increases receptor affinity,
enhances receptor coupling to the G protein, increased G protein
stimulated adenyl cyclase
colchicine: cycle of blood cell damage - ANSWER ✔✔- leukocytosis,
then
leukopenia (48-72 hours)
pancytopenia
then rebound
From: Folpini et al: Colchicine toxicity. JToxClinTox 1995;33:71-77
what GHB analog has a pharmacokinetic interaction with ethanol? -
ANSWER ✔✔- 1,4-butandediol (1,4-BD)
- 1,4-BD is metabolized by alcohol dehydrogenase, as is GHB
- coingestion can delay and prolong clinical effects
how is thujone toxic? - ANSWER ✔✔- GABA-A antagonism, in
absinthe
- antagonizes GABA-A receptor at the picrotoxin site on the chloride
channel
- effects: neuroexcitation (hallucinations or seizures)
zinc deficiency (3 features) - ANSWER ✔✔- 1. alopecia
2|Page
, 2. diarrhea
3. dermatitis
- either autosomal recessive or acquired
- TPN w/o zinc, intestinal bypass, Crohn's, preemies
aka acrodermatitis enteropathica
rapid acetylators and INH toxicity - ANSWER ✔✔- clinically: same risk
for hepatotoxicity, lower risk for neurotoxicity as normal acetylators
cadmium toxicity (3 cellular functions) - ANSWER ✔✔- 1. binding to
sulfhydryl groups (denaturing proteins and inactivating enzymes)
2. interference with cell-cell adhesion (cadherins E &N, and B-catenin)
3. interference with calcium transport mechanisms
vitamin A induced hepatotoxicity - ANSWER ✔✔- cirrhosis:
proliferative effect on Ito cells, depositing excessive collagen and
causing liver scarring
how does lead cause anemia? - ANSWER ✔✔- decreased hemoglobin
synthesis
other effects: increased production of RBCs and increased release of
reticulocytes to compensate for decreased hgb synthesis
3|Page
