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PCOL 838b Exam 1 2025/2026 Exam
Questions and Verified Answers |
Already Graded A+
MHC Class I - 🧠 ANSWER ✔✔display antigens from intracellular pathogens
interact with CD8
expressed on ALL cells
MCH Class II - 🧠 ANSWER ✔✔display antigens from extracellular pathogens.
interact with CD4
expressed on APCs
humoral immunity - 🧠 ANSWER ✔✔antibody-mediated immunity
involves B cells
cell-mediated immunity - 🧠 ANSWER ✔✔type of immunity produced by T cells
that attack infected or abnormal body cells
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COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
STATEMENT. ALL RIGHTS RESERVED
, 2
isotype of antibody - 🧠 ANSWER ✔✔determined by constant region of heavy
chain
somatic recombination - 🧠 ANSWER ✔✔gene segments of antibody rearrange to
form variable domain gene
junctional diversity - 🧠 ANSWER ✔✔source of antibody diversity
RAG yields DNA hairpin which is then cleaved, TdT adds nucleotides at random,
gaps filled by DNA synthesis
isotope class switching - 🧠 ANSWER ✔✔VDJ region is brought to a new constant
region of the heavy chain
heavy chain constant region determined by cytokines
constant region=isotype
isotype class switching signals - 🧠 ANSWER ✔✔1. CD40 ligand (on T cell)
interacts with CD40 on B cell
2. Cytokine determines isotype class
memory B cell formation - 🧠 ANSWER ✔✔1. B cell interacts with T cell via
antigen-MHC and CD40-CD40 L
2. Cytokine released from T cell
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COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
STATEMENT. ALL RIGHTS RESERVED
PCOL 838b Exam 1 2025/2026 Exam
Questions and Verified Answers |
Already Graded A+
MHC Class I - 🧠 ANSWER ✔✔display antigens from intracellular pathogens
interact with CD8
expressed on ALL cells
MCH Class II - 🧠 ANSWER ✔✔display antigens from extracellular pathogens.
interact with CD4
expressed on APCs
humoral immunity - 🧠 ANSWER ✔✔antibody-mediated immunity
involves B cells
cell-mediated immunity - 🧠 ANSWER ✔✔type of immunity produced by T cells
that attack infected or abnormal body cells
1
COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
STATEMENT. ALL RIGHTS RESERVED
, 2
isotype of antibody - 🧠 ANSWER ✔✔determined by constant region of heavy
chain
somatic recombination - 🧠 ANSWER ✔✔gene segments of antibody rearrange to
form variable domain gene
junctional diversity - 🧠 ANSWER ✔✔source of antibody diversity
RAG yields DNA hairpin which is then cleaved, TdT adds nucleotides at random,
gaps filled by DNA synthesis
isotope class switching - 🧠 ANSWER ✔✔VDJ region is brought to a new constant
region of the heavy chain
heavy chain constant region determined by cytokines
constant region=isotype
isotype class switching signals - 🧠 ANSWER ✔✔1. CD40 ligand (on T cell)
interacts with CD40 on B cell
2. Cytokine determines isotype class
memory B cell formation - 🧠 ANSWER ✔✔1. B cell interacts with T cell via
antigen-MHC and CD40-CD40 L
2. Cytokine released from T cell
2
COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
STATEMENT. ALL RIGHTS RESERVED
