BCH403 FINAL REVIEW
COMPREHENSIVE QUESTIONS
AND ANSWERS
Which one of the following is the most important regulation site of glycolysis?
- Fructose-1,6-bisphosphatase
- hexokinase
- glucokinase
- phosphofructokinase-1
- pyruvate kinase - Answer- phosphofructokinase-1
during gluconeogensis, we convert oxaloacetate to malate. Why?
- malate activates phosphoenolpyruvate carboxykinase
- malate activates fructose-1,6-bisphosphatase
- malate can be transported into the mitochondria
- Malate can be transported into the cytosol
- Malate can be transported into the endoplasmic reticulum - Answer- - Malate can be
transported into the cytosol
Which one of the following molecules is the major end product of glycogenolysis?
- Glucose
- glucose-1-phosphate
-glucose-6-phosphate
- maltose
- fructose - Answer- glucose-1-phosphate
Which one of the following molecules can control glycogen synthesis and glycogen
breakdown on a per cell basis?
- glucagon
- insulin
- glucose
- AMP
- Glucose-6-Phosphate - Answer- Glucose-6-phosphate
Human pyruvate dehydrogenase complex is regulated by all of the following molecules
except ________?
,- Insulin
- Glucagon
- Acetyl-CoA
- ATP
- ADP - Answer- glucagon
How many electrons does each cytochrome c protein donate to complex IV?
1
2
3
4
0 - Answer- 1
Which component of the F0 subunit rotates?
- a subunit
- b subunit
- c subunit
- d subunit
- stator - Answer- c subunit
Anaerobic catabolism of glucose results in the formation of:
- 2 ATP and 2 NADH
- 4 ATP and 2 NADH
- 32 ATP
- 4 ATP, 10 NADH, and 2 FADH2
- 2 ATP - Answer- 2 ATP
How many molecules of O2 can be completely reduced to H20 using electrons donated
from NADH generated by glycolysis (assume 1 molecule of glucose)?
0
1
2
3
4 - Answer- 1
T/F: Two different lipases are required to cleave all three fatty acid side chains from
triacylglycerol stored in adipose tissue - Answer- False
T/F: transport of fatty acids into the mitochondria is the main regulatory step of B-
oxidation - Answer- True
T/F: Vitamin D3 can be synthesized from cholesterol - Answer- False
, T/F: Because we are able to store nitrogen as urea, we do not need to constantly
replenish our amino acids from our diet - Answer- False
T/F: Biochemical starvation caused by the absence of pancreatic B-cells is classified as
Type I diabetes - Answer- True
T/F: Chylomicron is synthesized in mucosal cells of the small intestine - Answer- True
T/F: The liver is the only tissue in the body that can use ketone bodies for fuel - Answer-
False
T/F: Glycerol-3-Phsphate acyltransferase is the regulatory step of triacylglycerol
biosynthesis - Answer- True
T/F: Cardiac muscles prefer fatty acids as their primary fuel source - Answer- True
T/F: Acetyl-CoA can be used to synthesize glucose during gluconeogenesis - Answer-
False
Which one of the following enzymes is capable of cleaving all three fatty acid side
chains off of a glycerol backbone?
- Lipoprotein lipase
- Pancreatic lipase
- adipose triglyceride lipase
- hormone sensitive lipase
-salivary lipase - Answer- Lipoprotein lipase
Non-palmitate fatty acid biosynthesis occurs in which organelle of the cell?
- cytosol
- Mitochondria
- nucleus
- Endoplasmic reticulum
- Golgi Apparatus - Answer- Endoplasmic Reticulum
Which one of the following states the correct order of reactions in B-oxidation? Assume
saturated fatty acid.
- Dehydrogenation (oxidation), dehydration, dehydrogenation (oxidation) , thiolytic
cleavage
- Condensation, reduction, dehydration, reduction, transfer
- Dehydrogenation (oxidation), hydration, dehydrogenation (oxidation), thiolytic cleavage
- reduction, dehydration, reduction, condensation
COMPREHENSIVE QUESTIONS
AND ANSWERS
Which one of the following is the most important regulation site of glycolysis?
- Fructose-1,6-bisphosphatase
- hexokinase
- glucokinase
- phosphofructokinase-1
- pyruvate kinase - Answer- phosphofructokinase-1
during gluconeogensis, we convert oxaloacetate to malate. Why?
- malate activates phosphoenolpyruvate carboxykinase
- malate activates fructose-1,6-bisphosphatase
- malate can be transported into the mitochondria
- Malate can be transported into the cytosol
- Malate can be transported into the endoplasmic reticulum - Answer- - Malate can be
transported into the cytosol
Which one of the following molecules is the major end product of glycogenolysis?
- Glucose
- glucose-1-phosphate
-glucose-6-phosphate
- maltose
- fructose - Answer- glucose-1-phosphate
Which one of the following molecules can control glycogen synthesis and glycogen
breakdown on a per cell basis?
- glucagon
- insulin
- glucose
- AMP
- Glucose-6-Phosphate - Answer- Glucose-6-phosphate
Human pyruvate dehydrogenase complex is regulated by all of the following molecules
except ________?
,- Insulin
- Glucagon
- Acetyl-CoA
- ATP
- ADP - Answer- glucagon
How many electrons does each cytochrome c protein donate to complex IV?
1
2
3
4
0 - Answer- 1
Which component of the F0 subunit rotates?
- a subunit
- b subunit
- c subunit
- d subunit
- stator - Answer- c subunit
Anaerobic catabolism of glucose results in the formation of:
- 2 ATP and 2 NADH
- 4 ATP and 2 NADH
- 32 ATP
- 4 ATP, 10 NADH, and 2 FADH2
- 2 ATP - Answer- 2 ATP
How many molecules of O2 can be completely reduced to H20 using electrons donated
from NADH generated by glycolysis (assume 1 molecule of glucose)?
0
1
2
3
4 - Answer- 1
T/F: Two different lipases are required to cleave all three fatty acid side chains from
triacylglycerol stored in adipose tissue - Answer- False
T/F: transport of fatty acids into the mitochondria is the main regulatory step of B-
oxidation - Answer- True
T/F: Vitamin D3 can be synthesized from cholesterol - Answer- False
, T/F: Because we are able to store nitrogen as urea, we do not need to constantly
replenish our amino acids from our diet - Answer- False
T/F: Biochemical starvation caused by the absence of pancreatic B-cells is classified as
Type I diabetes - Answer- True
T/F: Chylomicron is synthesized in mucosal cells of the small intestine - Answer- True
T/F: The liver is the only tissue in the body that can use ketone bodies for fuel - Answer-
False
T/F: Glycerol-3-Phsphate acyltransferase is the regulatory step of triacylglycerol
biosynthesis - Answer- True
T/F: Cardiac muscles prefer fatty acids as their primary fuel source - Answer- True
T/F: Acetyl-CoA can be used to synthesize glucose during gluconeogenesis - Answer-
False
Which one of the following enzymes is capable of cleaving all three fatty acid side
chains off of a glycerol backbone?
- Lipoprotein lipase
- Pancreatic lipase
- adipose triglyceride lipase
- hormone sensitive lipase
-salivary lipase - Answer- Lipoprotein lipase
Non-palmitate fatty acid biosynthesis occurs in which organelle of the cell?
- cytosol
- Mitochondria
- nucleus
- Endoplasmic reticulum
- Golgi Apparatus - Answer- Endoplasmic Reticulum
Which one of the following states the correct order of reactions in B-oxidation? Assume
saturated fatty acid.
- Dehydrogenation (oxidation), dehydration, dehydrogenation (oxidation) , thiolytic
cleavage
- Condensation, reduction, dehydration, reduction, transfer
- Dehydrogenation (oxidation), hydration, dehydrogenation (oxidation), thiolytic cleavage
- reduction, dehydration, reduction, condensation
