NR 568 weeks 5-8, Final exam 218
complete solutions.
NR 568 weeks 5-8, Final exam 218
complete solutions.
How do you manage Parkinsons disease in early stages - ANSWER Either with Pramipexole (mirapex) OR
Rotigotine (Neupro)
What is the most effective therapy for PD - ANSWER Combination therapy with levodopa/carbidopa or
levodopa/carbidopa/entacapone
What medications are used to treat off times including wearing off experiences - ANSWER Dopamine
agonists, COMT inhibitors and MAO-B inhibitors.
Entacapone-COMT- inhibitor
Rasagiline- MAO- B inhibitor
Adverse effects of Pramipexole - ANSWER Nausea, dizziness, daytime somnolence, insomnia,
constipation, weakness, and hallucinations, impulse control disorders
Which medication is the safest choice for someone on oral contraceptive - ANSWER Pregabalin
What is the purpose and timing of serum drug levels - ANSWER small changes in dosage produce large
changes in plasma levels, as a result small increases in dosage can cause toxicity and small decreases can
cause therapeutic failure. this relationship makes it difficult to establish and maintain a dosage that is
both safe and effective. for this reason, serum drug levels and trough levels are often used along with
assessments of seizure control o determine dosage.
Phenytoin drug interactions - ANSWER Oxcarbazepine inhibits the enzymes that metabolize phenytoin
thus raising phenytoin. Controversially phenytoin may decrease serum concentrations of oxcarbazepine
,NR 568 weeks 5-8, Final exam 218
complete solutions.
What can happen when you take phenytoin and oxcarbazepine together - ANSWER phenytoin toxicity
and subtherapeutic levels of oxcarbazepine can occur. These levels should be monitored and dosages
adjusted accordingly.
What is first line therapy for migraines and headaches? - ANSWER OTC medications such as Tylenol and
Advil
What medications can help prevent migraine attacks - ANSWER Propranolol metoprolol and 3 beta
blockers- timolol, atenolol and nadolol
what drugs can cause medication overuse headache - ANSWER almost all medications used for abortive
headache therapy: aspirin-like drugs, opioids, triptans, ergotamine- but not dihydroergotamine, and
caffeine
What measures can decrease MOH - ANSWER limit use of abortive medications. patient should not take
these drugs no more than 2-3 times a week and doses should not be higher than actually needed
What are contraindications for sumatriptan - ANSWER all triptans are contraindicated for patients with
ischemic heart disease, prior MI or uncontrolled HTN
What are alternative medications for migraines - ANSWER Beta blockers
antiseizure drugs
tricyclic antidepressants
estrogens and triptans for menstrual associated migraines
erenumab
botulinum toxin
what is the drug of choice for moderate alzheimers disease - ANSWER cholinesterase inhibitor: Aricept,
Razadyne ER and Exelon
, NR 568 weeks 5-8, Final exam 218
complete solutions.
Is it recommended to combine two cholinesterase inhibitors - ANSWER no
What is memantine indicated for - ANSWER mild to moderate AD, it is NOT indicated with mild AD as
studies have not shown symptom improvement
how is Rivastigmine (Exelon) administered - ANSWER orally or transdermal patch
where does Rivastigmine act on - ANSWER both acetylcholinesterase and butyrylcholinesterase thereby
increasing its efficacy.
Who should not take rivastigmine - ANSWER patients with COPD
Does Rivastigmine and galantamine require tappering - ANSWER no
what is the recommended starting dose for rivastigmine - ANSWER 1.5mg BID
What is Donepezil approved to tx - ANSWER moderate to severe AD
What dose is Donepezil given - ANSWER can dose at 23mg/day however there is minimal evidence to
show improvement from 10mg to 23mg. 23mg dose has shown to have more adverse effects
Does donepezil require tappering - ANSWER yes
Besides AD what else does donepezil treat - ANSWER anxiety, depression, apathy, delusions and pacing
what is the only NMDA drug approved to manage moderate to severe AD - ANSWER Memantine
what drug is associated with an increased life expectancy than that of donepezil - ANSWER Memantine
complete solutions.
NR 568 weeks 5-8, Final exam 218
complete solutions.
How do you manage Parkinsons disease in early stages - ANSWER Either with Pramipexole (mirapex) OR
Rotigotine (Neupro)
What is the most effective therapy for PD - ANSWER Combination therapy with levodopa/carbidopa or
levodopa/carbidopa/entacapone
What medications are used to treat off times including wearing off experiences - ANSWER Dopamine
agonists, COMT inhibitors and MAO-B inhibitors.
Entacapone-COMT- inhibitor
Rasagiline- MAO- B inhibitor
Adverse effects of Pramipexole - ANSWER Nausea, dizziness, daytime somnolence, insomnia,
constipation, weakness, and hallucinations, impulse control disorders
Which medication is the safest choice for someone on oral contraceptive - ANSWER Pregabalin
What is the purpose and timing of serum drug levels - ANSWER small changes in dosage produce large
changes in plasma levels, as a result small increases in dosage can cause toxicity and small decreases can
cause therapeutic failure. this relationship makes it difficult to establish and maintain a dosage that is
both safe and effective. for this reason, serum drug levels and trough levels are often used along with
assessments of seizure control o determine dosage.
Phenytoin drug interactions - ANSWER Oxcarbazepine inhibits the enzymes that metabolize phenytoin
thus raising phenytoin. Controversially phenytoin may decrease serum concentrations of oxcarbazepine
,NR 568 weeks 5-8, Final exam 218
complete solutions.
What can happen when you take phenytoin and oxcarbazepine together - ANSWER phenytoin toxicity
and subtherapeutic levels of oxcarbazepine can occur. These levels should be monitored and dosages
adjusted accordingly.
What is first line therapy for migraines and headaches? - ANSWER OTC medications such as Tylenol and
Advil
What medications can help prevent migraine attacks - ANSWER Propranolol metoprolol and 3 beta
blockers- timolol, atenolol and nadolol
what drugs can cause medication overuse headache - ANSWER almost all medications used for abortive
headache therapy: aspirin-like drugs, opioids, triptans, ergotamine- but not dihydroergotamine, and
caffeine
What measures can decrease MOH - ANSWER limit use of abortive medications. patient should not take
these drugs no more than 2-3 times a week and doses should not be higher than actually needed
What are contraindications for sumatriptan - ANSWER all triptans are contraindicated for patients with
ischemic heart disease, prior MI or uncontrolled HTN
What are alternative medications for migraines - ANSWER Beta blockers
antiseizure drugs
tricyclic antidepressants
estrogens and triptans for menstrual associated migraines
erenumab
botulinum toxin
what is the drug of choice for moderate alzheimers disease - ANSWER cholinesterase inhibitor: Aricept,
Razadyne ER and Exelon
, NR 568 weeks 5-8, Final exam 218
complete solutions.
Is it recommended to combine two cholinesterase inhibitors - ANSWER no
What is memantine indicated for - ANSWER mild to moderate AD, it is NOT indicated with mild AD as
studies have not shown symptom improvement
how is Rivastigmine (Exelon) administered - ANSWER orally or transdermal patch
where does Rivastigmine act on - ANSWER both acetylcholinesterase and butyrylcholinesterase thereby
increasing its efficacy.
Who should not take rivastigmine - ANSWER patients with COPD
Does Rivastigmine and galantamine require tappering - ANSWER no
what is the recommended starting dose for rivastigmine - ANSWER 1.5mg BID
What is Donepezil approved to tx - ANSWER moderate to severe AD
What dose is Donepezil given - ANSWER can dose at 23mg/day however there is minimal evidence to
show improvement from 10mg to 23mg. 23mg dose has shown to have more adverse effects
Does donepezil require tappering - ANSWER yes
Besides AD what else does donepezil treat - ANSWER anxiety, depression, apathy, delusions and pacing
what is the only NMDA drug approved to manage moderate to severe AD - ANSWER Memantine
what drug is associated with an increased life expectancy than that of donepezil - ANSWER Memantine
