WGU D027 ADVANCED
PATHOPHARMACOLOGICAL
FOUNDATIONS QUESTIONS AND
ANSWERS WITH VERIFIED SOLUTIONS
100% CORRECT !!!
A 26-year-old female presents with fatigue, muscle aches, abdominal pain,
tingling in extremities, bloating, and constipation following recent use of anti-
diarrheals. She reports GI upset after meals. Antibody testing suggests Celiac
disease.
What is the gold standard follow-up test to confirm the diagnosis?
A. Abdominal X-ray
B. Colonoscopy
✔✔ C. Endoscopy with small intestine biopsy
D. Capsule endoscopy
📝 Explanation: The definitive diagnosis for Celiac disease is made through an
upper endoscopy with biopsy of the small intestine to assess for villous atrophy.
A 44-year-old woman with advanced metastatic non-small-cell lung cancer
undergoes genetic testing. She is started on osimertinib (Tagrisso).
Which genetic mutation is most likely present?
A. ALK mutation
✔✔ B. EGFR mutation
C. BRCA mutation
D. MET amplification mutation
📝 Explanation: Osimertinib is an EGFR tyrosine kinase inhibitor, commonly used
for NSCLC patients who test positive for EGFR mutations.
A 20-year-old male reports a long history of toe-walking, frequent falls, and
difficulty standing. His symptoms have worsened over the years, and he now
experiences stiffness and progressive weakness. No family history of genetic
,conditions is noted.
What is the most likely diagnosis?
✔✔ A. Becker muscular dystrophy
B. Myotonic dystrophy
C. Facioscapulohumeral muscular dystrophy (FSHD)
D. Limb-girdle muscular dystrophy
📝 Explanation: Becker muscular dystrophy typically presents in late childhood or
adolescence with progressive muscle weakness, difficulty with mobility, and
preserved cognition. It’s a milder, slower-progressing form of Duchenne muscular
dystrophy.
Which statement should the provider give the patient regarding the
pathophysiology of SLE and its relation to thrombocytopenia?
A. SLE disrupts immune homeostasis and promotes development of self-reactive
antibodies.
B. SLE causes a cross-reaction of antibodies with normal platelet antigens.
C. SLE causes a defect in the number and function of regulatory B cells.
D. SLE increases megakaryocyte maturation. - ANSWER✔✔A. SLE disrupts
immune homeostasis and promotes development of self-reactive antibodies
A female patient presents to an office to establish care. Her previous primary care
provider told her to follow up regarding an elevated ferritin level. She has no
previous medical history and is currently asymptomatic. She is concerned about
the elevated ferritin and would like to know if she should be worried.
What should the provider do next for this patient?
A. Order a liver function test
, B. Order a renal ultrasound
C. Refer her for a bone marrow biopsy
D. Order a thyroid panel - ANSWER✔✔A. Order a liver function test
A 75-year-old female presents to the emergency department with an irregular heart
rate of 130.
What can be ascertained about this patient's findings given the limited information?
A. She has a normal sinus rhythm and needs her heart rate controlled with
metoprolol (Lopressor).
B. She is diagnosed with atrial fibrillation and needs her heart rate controlled with
metoprolol (Lopressor).
C. She is diagnosed with ventricular tachycardia and needs her heart rhythm
controlled with metoprolol (Lopressor).
D. She is diagnosed with torsades de pointes and needs her heart rate controlled
with magnesium. - ANSWER✔✔B. She is diagnosed with atrial fibrillation and
needs her heart rate controlled with metoprolol (Lopressor)
Which condition from this patient's medical history is contributing to the loss of
contractility?
A. Atrial fibrillation
B. Acute myocardial infarction
C. Angina
D. Transient ischemic attack - ANSWER✔✔B. Acute myocardial infarction
PATHOPHARMACOLOGICAL
FOUNDATIONS QUESTIONS AND
ANSWERS WITH VERIFIED SOLUTIONS
100% CORRECT !!!
A 26-year-old female presents with fatigue, muscle aches, abdominal pain,
tingling in extremities, bloating, and constipation following recent use of anti-
diarrheals. She reports GI upset after meals. Antibody testing suggests Celiac
disease.
What is the gold standard follow-up test to confirm the diagnosis?
A. Abdominal X-ray
B. Colonoscopy
✔✔ C. Endoscopy with small intestine biopsy
D. Capsule endoscopy
📝 Explanation: The definitive diagnosis for Celiac disease is made through an
upper endoscopy with biopsy of the small intestine to assess for villous atrophy.
A 44-year-old woman with advanced metastatic non-small-cell lung cancer
undergoes genetic testing. She is started on osimertinib (Tagrisso).
Which genetic mutation is most likely present?
A. ALK mutation
✔✔ B. EGFR mutation
C. BRCA mutation
D. MET amplification mutation
📝 Explanation: Osimertinib is an EGFR tyrosine kinase inhibitor, commonly used
for NSCLC patients who test positive for EGFR mutations.
A 20-year-old male reports a long history of toe-walking, frequent falls, and
difficulty standing. His symptoms have worsened over the years, and he now
experiences stiffness and progressive weakness. No family history of genetic
,conditions is noted.
What is the most likely diagnosis?
✔✔ A. Becker muscular dystrophy
B. Myotonic dystrophy
C. Facioscapulohumeral muscular dystrophy (FSHD)
D. Limb-girdle muscular dystrophy
📝 Explanation: Becker muscular dystrophy typically presents in late childhood or
adolescence with progressive muscle weakness, difficulty with mobility, and
preserved cognition. It’s a milder, slower-progressing form of Duchenne muscular
dystrophy.
Which statement should the provider give the patient regarding the
pathophysiology of SLE and its relation to thrombocytopenia?
A. SLE disrupts immune homeostasis and promotes development of self-reactive
antibodies.
B. SLE causes a cross-reaction of antibodies with normal platelet antigens.
C. SLE causes a defect in the number and function of regulatory B cells.
D. SLE increases megakaryocyte maturation. - ANSWER✔✔A. SLE disrupts
immune homeostasis and promotes development of self-reactive antibodies
A female patient presents to an office to establish care. Her previous primary care
provider told her to follow up regarding an elevated ferritin level. She has no
previous medical history and is currently asymptomatic. She is concerned about
the elevated ferritin and would like to know if she should be worried.
What should the provider do next for this patient?
A. Order a liver function test
, B. Order a renal ultrasound
C. Refer her for a bone marrow biopsy
D. Order a thyroid panel - ANSWER✔✔A. Order a liver function test
A 75-year-old female presents to the emergency department with an irregular heart
rate of 130.
What can be ascertained about this patient's findings given the limited information?
A. She has a normal sinus rhythm and needs her heart rate controlled with
metoprolol (Lopressor).
B. She is diagnosed with atrial fibrillation and needs her heart rate controlled with
metoprolol (Lopressor).
C. She is diagnosed with ventricular tachycardia and needs her heart rhythm
controlled with metoprolol (Lopressor).
D. She is diagnosed with torsades de pointes and needs her heart rate controlled
with magnesium. - ANSWER✔✔B. She is diagnosed with atrial fibrillation and
needs her heart rate controlled with metoprolol (Lopressor)
Which condition from this patient's medical history is contributing to the loss of
contractility?
A. Atrial fibrillation
B. Acute myocardial infarction
C. Angina
D. Transient ischemic attack - ANSWER✔✔B. Acute myocardial infarction
