Hematology
Final Test Review
(Questions & Solutions)
2025
1
,1. A 30-year-old woman presents with fatigue and pallor. Laboratory
tests reveal a positive direct antiglobulin (Coombs) test and spherocytes
on the peripheral smear. Which is the most likely diagnosis?
A) Hereditary spherocytosis
B) Autoimmune hemolytic anemia
C) Iron deficiency anemia
D) Thalassemia minor
Correct ANS: B
Rationale: A positive Coombs test indicates immune-mediated hemolysis,
consistent with autoimmune hemolytic anemia.
2. Which of the following autoantibodies is most specifically associated
with systemic lupus erythematosus (SLE)?
A) Anti-centromere antibody
B) Anti-dsDNA antibody
C) Anti-Ro/SSA antibody
D) Anti-smooth muscle antibody
Correct ANS: B
Rationale: Anti-dsDNA antibodies are highly specific for SLE.
3. Warm antibody autoimmune hemolytic anemia is primarily mediated
by which immunoglobulin class?
A) IgD
B) IgE
C) IgG
D) IgM
Correct ANS: C
Rationale: IgG autoantibodies are implicated in warm AIHA.
4. Which of the following is NOT a typical laboratory finding in
autoimmune hemolytic anemia?
A) Elevated LDH
B) Elevated haptoglobin
C) Spherocytes on blood smear
2
, D) Increased indirect bilirubin
Correct ANS: B
Rationale: Haptoglobin is decreased due to binding free hemoglobin in
hemolysis.
5. The first-line therapy for immune thrombocytopenic purpura (ITP) is:
A) Platelet transfusion
B) Corticosteroids
C) Immunoglobulin replacement
D) Splenectomy
Correct ANS: B
Rationale: Corticosteroids are first-line therapy; splenectomy is reserved
for refractory cases.
Coagulation Disorders
6. A deficiency of which factor is responsible for the congenital bleeding
disorder Hemophilia A?
A) Factor IX
B) Factor VIII
C) Factor XI
D) Factor V
Correct ANS: B
Rationale: Hemophilia A is caused by a deficiency of factor VIII.
7. Which of the following is a common initial laboratory finding in von
Willebrand Disease?
A) Prolonged prothrombin time (PT)
B) Prolonged activated partial thromboplastin time (aPTT)
C) Prolonged bleeding time
D) Elevated fibrinogen levels
Correct ANS: C
Rationale: Bleeding time is often prolonged due to impaired platelet
adhesion.
8. A patient with hemophilia B will have a deficiency in which coagulation
3
Final Test Review
(Questions & Solutions)
2025
1
,1. A 30-year-old woman presents with fatigue and pallor. Laboratory
tests reveal a positive direct antiglobulin (Coombs) test and spherocytes
on the peripheral smear. Which is the most likely diagnosis?
A) Hereditary spherocytosis
B) Autoimmune hemolytic anemia
C) Iron deficiency anemia
D) Thalassemia minor
Correct ANS: B
Rationale: A positive Coombs test indicates immune-mediated hemolysis,
consistent with autoimmune hemolytic anemia.
2. Which of the following autoantibodies is most specifically associated
with systemic lupus erythematosus (SLE)?
A) Anti-centromere antibody
B) Anti-dsDNA antibody
C) Anti-Ro/SSA antibody
D) Anti-smooth muscle antibody
Correct ANS: B
Rationale: Anti-dsDNA antibodies are highly specific for SLE.
3. Warm antibody autoimmune hemolytic anemia is primarily mediated
by which immunoglobulin class?
A) IgD
B) IgE
C) IgG
D) IgM
Correct ANS: C
Rationale: IgG autoantibodies are implicated in warm AIHA.
4. Which of the following is NOT a typical laboratory finding in
autoimmune hemolytic anemia?
A) Elevated LDH
B) Elevated haptoglobin
C) Spherocytes on blood smear
2
, D) Increased indirect bilirubin
Correct ANS: B
Rationale: Haptoglobin is decreased due to binding free hemoglobin in
hemolysis.
5. The first-line therapy for immune thrombocytopenic purpura (ITP) is:
A) Platelet transfusion
B) Corticosteroids
C) Immunoglobulin replacement
D) Splenectomy
Correct ANS: B
Rationale: Corticosteroids are first-line therapy; splenectomy is reserved
for refractory cases.
Coagulation Disorders
6. A deficiency of which factor is responsible for the congenital bleeding
disorder Hemophilia A?
A) Factor IX
B) Factor VIII
C) Factor XI
D) Factor V
Correct ANS: B
Rationale: Hemophilia A is caused by a deficiency of factor VIII.
7. Which of the following is a common initial laboratory finding in von
Willebrand Disease?
A) Prolonged prothrombin time (PT)
B) Prolonged activated partial thromboplastin time (aPTT)
C) Prolonged bleeding time
D) Elevated fibrinogen levels
Correct ANS: C
Rationale: Bleeding time is often prolonged due to impaired platelet
adhesion.
8. A patient with hemophilia B will have a deficiency in which coagulation
3
