NURS8024 Pharm Exam 1 ACTUAL COMPLETE REAL
EXAM TEST QUESTIONS & CORRECTANSWERS
(A+ GRADED 100% VERIFIED) 2025/2026 NEWEST!!
Anti-Inflammatory Agents-Corticosteroids - ANSWER-•
Efficacy of topical
corticosteroids for tx inflammatory
dermatoses
• Numerous types available w/ choices of potencies,
concentrations, and
vehicles
• Anti-inflammatory and
antimitotic effects
• Original-
hydrocortisone
*Therapeutic effectiveness -based primarily on their anti-
inflammatory activity*
Topical Corticosteroids - ANSWER-• Minimally absorbed w/
application to normal skin
• Significantly increased absorption in inflamed skin (atopic
dermatitis etc.)
,• Occlusion w/ plastic wrap -tenfold increase in absorption
*• Significant regional anatomic variation in corticosteroid
penetration
• Compared w/ absorption from the forearm, hydrocortisone is
absorbed
• 0.14 times as well through the plantar foot arch
• 0.83 times as well through the palm
• 3.5 times as well through the scalp
• 6 times as well through the forehead
• 9 times as well through vulvar skin
• 42 times as well through scrotal skin
Adverse systemic effects of topical corticosteroids - ANSWER-•
All absorbable topical corticosteroids have potential to
suppress Hypothalamic Pituitary adrenal (HPA) axis
• Iatrogenic Cushing's syndrome can occur as a result of long
term use of topical corticosteroids in large quantities
• Steroid induced glaucoma/cataracts
* Adverse systemic effects in children-may take lesser
amt/duration for ADE-
growth retardation
possible
,• Pregnancy -caution advised-esp. 1st
trimester
• Geriatric patients more susceptible to
secondary infection
Adverse local effects of topical corticosteroids - ANSWER-
Atrophy-shiny,
depressed, wrinkled appearing skin with prominent
telangiectasia
-Purpura and ecchymosis
- Telangiectatic vessels, pustules, and papules
-Perioral dermatitis
- Steroid acne
- hypopigmentation
- Hypertrichosis
- Increased intraocular pressure
- worsening of cutaneous infections
Capsaicin - ANSWER-• Naturally occurring substance derived
from hot chili peppers
• Exact MOA unknown
• Initially stimulates then desensitizes and degenerates
cutaneous nociceptive neurons
, • Causes local depletion of substance P, involved in sensory
perception and pain transmission • Available as a 0.025%
cream and 0.075% cream
• Apply 3-4 x daily
• Used for Tx postherpetic neuralgia, painful diabetic
neuropathy, being investigated for Tx psoriasis, vitiligo,
intractable pruritus
Geriatric Changes in functional capacities include - ANSWER-
Most major organ systems show decline beginning in young
adulthood and continuing throughout the lifespan
Geriatric medication absorption - ANSWER-Large GI surface
area- absorption
usually not affected (passive
diffusion)
Compounds requiring active transport in Geriatrics may have
delayed absorption due to: - ANSWER-GI changes w/ age -
reduction in acid (more alkaline environment)
• Reduction in
• Blood flow
• Enzyme activity
• Gastric emptying
• Bowel motility
EXAM TEST QUESTIONS & CORRECTANSWERS
(A+ GRADED 100% VERIFIED) 2025/2026 NEWEST!!
Anti-Inflammatory Agents-Corticosteroids - ANSWER-•
Efficacy of topical
corticosteroids for tx inflammatory
dermatoses
• Numerous types available w/ choices of potencies,
concentrations, and
vehicles
• Anti-inflammatory and
antimitotic effects
• Original-
hydrocortisone
*Therapeutic effectiveness -based primarily on their anti-
inflammatory activity*
Topical Corticosteroids - ANSWER-• Minimally absorbed w/
application to normal skin
• Significantly increased absorption in inflamed skin (atopic
dermatitis etc.)
,• Occlusion w/ plastic wrap -tenfold increase in absorption
*• Significant regional anatomic variation in corticosteroid
penetration
• Compared w/ absorption from the forearm, hydrocortisone is
absorbed
• 0.14 times as well through the plantar foot arch
• 0.83 times as well through the palm
• 3.5 times as well through the scalp
• 6 times as well through the forehead
• 9 times as well through vulvar skin
• 42 times as well through scrotal skin
Adverse systemic effects of topical corticosteroids - ANSWER-•
All absorbable topical corticosteroids have potential to
suppress Hypothalamic Pituitary adrenal (HPA) axis
• Iatrogenic Cushing's syndrome can occur as a result of long
term use of topical corticosteroids in large quantities
• Steroid induced glaucoma/cataracts
* Adverse systemic effects in children-may take lesser
amt/duration for ADE-
growth retardation
possible
,• Pregnancy -caution advised-esp. 1st
trimester
• Geriatric patients more susceptible to
secondary infection
Adverse local effects of topical corticosteroids - ANSWER-
Atrophy-shiny,
depressed, wrinkled appearing skin with prominent
telangiectasia
-Purpura and ecchymosis
- Telangiectatic vessels, pustules, and papules
-Perioral dermatitis
- Steroid acne
- hypopigmentation
- Hypertrichosis
- Increased intraocular pressure
- worsening of cutaneous infections
Capsaicin - ANSWER-• Naturally occurring substance derived
from hot chili peppers
• Exact MOA unknown
• Initially stimulates then desensitizes and degenerates
cutaneous nociceptive neurons
, • Causes local depletion of substance P, involved in sensory
perception and pain transmission • Available as a 0.025%
cream and 0.075% cream
• Apply 3-4 x daily
• Used for Tx postherpetic neuralgia, painful diabetic
neuropathy, being investigated for Tx psoriasis, vitiligo,
intractable pruritus
Geriatric Changes in functional capacities include - ANSWER-
Most major organ systems show decline beginning in young
adulthood and continuing throughout the lifespan
Geriatric medication absorption - ANSWER-Large GI surface
area- absorption
usually not affected (passive
diffusion)
Compounds requiring active transport in Geriatrics may have
delayed absorption due to: - ANSWER-GI changes w/ age -
reduction in acid (more alkaline environment)
• Reduction in
• Blood flow
• Enzyme activity
• Gastric emptying
• Bowel motility
