HSCT Questions with complete solution
2025
HSCT is the IV infusion of hematopoietic stems cells (HSCs) into a recipient
after admin of___ - correct answers HD chemotherapy
Rationales for HSCT
1. Able to admin_____ as myelosupp. (MLS) is the dose limiting tox (DLT) for
many chemo agents
2. Provide ___marrow
3. ____effect which essentially will provide an army of T cells to detect and kill
tumor cells--> changing tumor microenvironment - correct answers 1. higher
doses of chemo which may be needed for the tumor cells resistant to standard
doses
2. new functional
3. Graft vs. tumor or leukemia effect (GVT/GVL)
by age 20, these sites have rapidly declining sites of HSC production - correct
answers long bones: tibia and femur
at 20 still have high levels of HSC production in which areas (i.e, the bone
marrow in these areas produces the HSCs) - correct answers vertebrae
pelvis
sternum
ribs
prenatal sites of HSC production - correct answers yolk sac
liver
,spleen
bone marrow
Two types of allo HSCTs - correct answers related and unrelated
Types of related - correct answers MMR/Haplo-identical: mom or dad
Matched related (MRD): sibling
syngeneic (identical twins)
types of unrelated - correct answers Matched unrelated (MUD)
Mismatched unrelated
Mismatched unrelated comes from___ - correct answers National Donor
Program,
the types of related/unrelated are based on__ - correct answers HLA
role of auto HSCT:
`1. _____chemotherapy to
overcome drug resistance
2. Rescue the patient from myeloid ____effects
3. _____ toxicities becomes dose limiting - correct answers 1. dose
escalate/intensify
2. suppressive
3. other organ
role of allo HSCT:
, 1. Replace missing or abnormal hematopoietic or
lymphoid components
2. Rescue the recipient from myelo____therapy
3. Establish ___effect - correct answers 2. ablative
3. GVT--> since patient's tumor cells would be recog. as foreign by the graft
advantages of auto HSCTs (usually a curative option but for some just to
improve PFS)
1. No need for-__matching
2. No GV___
3. lower risk for ___ complications - correct answers 1. HLA
2. GVHD
3. transplant-related
thus d/t no GVHD risk in auto HSCTs ___does not occur - correct answers
immunosuppression (with therapy)
disadvantages of auto HSCTs:
1. stem cells are damaged from____
2. possible contamination with___when collected
3. no__effects for killing tumors - correct answers 1. prior therapy b/c recall
HSCTs are 2nd or 3rd line options in diff. cancers like leukemias
2. tumors
3. GVT
thus because there is no GVT effect in auto HSCTs, there is a higher risk of__
- correct answers relapse
2025
HSCT is the IV infusion of hematopoietic stems cells (HSCs) into a recipient
after admin of___ - correct answers HD chemotherapy
Rationales for HSCT
1. Able to admin_____ as myelosupp. (MLS) is the dose limiting tox (DLT) for
many chemo agents
2. Provide ___marrow
3. ____effect which essentially will provide an army of T cells to detect and kill
tumor cells--> changing tumor microenvironment - correct answers 1. higher
doses of chemo which may be needed for the tumor cells resistant to standard
doses
2. new functional
3. Graft vs. tumor or leukemia effect (GVT/GVL)
by age 20, these sites have rapidly declining sites of HSC production - correct
answers long bones: tibia and femur
at 20 still have high levels of HSC production in which areas (i.e, the bone
marrow in these areas produces the HSCs) - correct answers vertebrae
pelvis
sternum
ribs
prenatal sites of HSC production - correct answers yolk sac
liver
,spleen
bone marrow
Two types of allo HSCTs - correct answers related and unrelated
Types of related - correct answers MMR/Haplo-identical: mom or dad
Matched related (MRD): sibling
syngeneic (identical twins)
types of unrelated - correct answers Matched unrelated (MUD)
Mismatched unrelated
Mismatched unrelated comes from___ - correct answers National Donor
Program,
the types of related/unrelated are based on__ - correct answers HLA
role of auto HSCT:
`1. _____chemotherapy to
overcome drug resistance
2. Rescue the patient from myeloid ____effects
3. _____ toxicities becomes dose limiting - correct answers 1. dose
escalate/intensify
2. suppressive
3. other organ
role of allo HSCT:
, 1. Replace missing or abnormal hematopoietic or
lymphoid components
2. Rescue the recipient from myelo____therapy
3. Establish ___effect - correct answers 2. ablative
3. GVT--> since patient's tumor cells would be recog. as foreign by the graft
advantages of auto HSCTs (usually a curative option but for some just to
improve PFS)
1. No need for-__matching
2. No GV___
3. lower risk for ___ complications - correct answers 1. HLA
2. GVHD
3. transplant-related
thus d/t no GVHD risk in auto HSCTs ___does not occur - correct answers
immunosuppression (with therapy)
disadvantages of auto HSCTs:
1. stem cells are damaged from____
2. possible contamination with___when collected
3. no__effects for killing tumors - correct answers 1. prior therapy b/c recall
HSCTs are 2nd or 3rd line options in diff. cancers like leukemias
2. tumors
3. GVT
thus because there is no GVT effect in auto HSCTs, there is a higher risk of__
- correct answers relapse
