BGZ2026 The Basic Principles of Pharmacology summary of all cases
Extensive summary of all cases with additional comments from the tutor
included
PROBLEM 1: THERAPEUTIC AND TOXIC EFFECTS OF COMPOUNDS – A
MATTER OF DOSE AND TIMING?
Problem statement:
Therapeutic and toxic effect of compounds – pharmacokinetics?
Brainstorm:
• Part 1A
Alcohol
The body and alcohol, body weight and composition
Into the liver: detoxication
Concentration per amount
Liver and kidney work them out of the body – metabolism
Coffee and waiting → how quickly is it broken down? Coffee influencing anything?
Enzyme function
• Part 1B
Multiple tablets → does the time of effect stretch?
Amount of enzymes
It may last longer, but not the double amount of time
• Part 1C
Overdoses of paracetamol → empty stomach
NAC
AST and ATL
Paracetamol level is 68 mg/ml → a high value
Metabolism → toxic
Learning goals:
1. What is the definition of pharmacokinetics?
2. What does ADME mean? (Absorption) (Distribution) (Metabolism) (Elimination)
3. What parameters describes the pharmacokinetics (volume of distribution, the clearance,
half-life of the drug, elimination constant and the absorption constant), T-max and C-max
Extensive summary of all cases with additional comments from the tutor
included
PROBLEM 1: THERAPEUTIC AND TOXIC EFFECTS OF COMPOUNDS – A
MATTER OF DOSE AND TIMING?
Problem statement:
Therapeutic and toxic effect of compounds – pharmacokinetics?
Brainstorm:
• Part 1A
Alcohol
The body and alcohol, body weight and composition
Into the liver: detoxication
Concentration per amount
Liver and kidney work them out of the body – metabolism
Coffee and waiting → how quickly is it broken down? Coffee influencing anything?
Enzyme function
• Part 1B
Multiple tablets → does the time of effect stretch?
Amount of enzymes
It may last longer, but not the double amount of time
• Part 1C
Overdoses of paracetamol → empty stomach
NAC
AST and ATL
Paracetamol level is 68 mg/ml → a high value
Metabolism → toxic
Learning goals:
1. What is the definition of pharmacokinetics?
2. What does ADME mean? (Absorption) (Distribution) (Metabolism) (Elimination)
3. What parameters describes the pharmacokinetics (volume of distribution, the clearance,
half-life of the drug, elimination constant and the absorption constant), T-max and C-max
