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Exam (elaborations)

Common and serious adverse effects to propylthiouracil and methimazole

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Propylthiouracil (PTU) and methimazole are antithyroid medications used to treat hyperthyroidism. Common adverse effects include rash, agranulocytosis (severe decrease in white blood cells), and liver toxicity (especially with PTU). Both drugs may lead to hypothyroidism if overused or improperly dosed. Methimazole is also associated with teratogenic effects (birth defects) if used during pregnancy, while PTU is preferred in the first trimester for this reason.

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Advance Nursing
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Common and serious adverse effects to
propylthiouracil and methimazole

What increased levels to report in nephrotoxicity? - Blood urea nitrogen and
creatinine levels


What to monitor for nephrotoxicity for abnormal test results - Urinalyses and
kidney function


What to treat purpuric maculopapular skin eruption if it becomes severe? -
Change to methimazole and short term oral steroids


When does purpuric maculopapular skin eruption occur? - The first 2 weeks of
therapy




The most common reaction in propylthiouracil therapy? - Purpuric maculopapular
skin eruption


Usual treatment for Purpuric maculopapular skin eruption - Spontaneous without
treatment


What are the symptoms of hepatotoxicity? - Anorexia
Nausea
Vomiting
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Uploaded on
June 22, 2025
Number of pages
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Written in
2024/2025
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  • propylthiouracil methimazole agranulocytosis
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