NUR 180 QUIZ 1 QUESTIONS & ANSWERS
What is a generic name medications? - Answers -the nonproprietary name that is
given by the United States Adopted Names Council. Each medication has only one
generic name.
What is a trade name medications? - Answers -is the brand or proprietary name given
by the company that manufactures the medication. One medication may have multiple
trade names.
What are the four components of pharmacokinetics? - Answers -absorption,
distribution, metabolism, excretion
What is absorption? - Answers -transmission of meds from location of admin to
bloodstream.
What is distribution? - Answers -the movement of drugs throughout the body
What is metabolism (biotransformation)? - Answers -The enzymatic alteration of drug
structure, most often takes place in the liver
What is excretion? - Answers -The removal of drugs from the body; can exit body
through urine, sweat, saliva, breast milk and expired air
What factors influence distribution? - Answers -Circulation: conditions that stop blood
flow/perfusion (peripheral vascular/cardiac disease)
Permeability of cell membrane: meds must be able to pass through tissues/membranes
to reach target area; meds that are lipid-soluble or have a transport system can cross
the blood-brain barrier and the placenta
Plasma protein binding: meds compete for protein binding sites within blood stream
(primarily albumin.
How do alterations influence target cells? - Answers -Plasma protein binding: meds
compete for protein binding sites within blood stream (primarily albumin. The ability of a
med to bind to protein can affect how much medication will leave/travel to target tissues.
Two meds can compete for same binding site resulting in toxicity.
How do enterohepatic complications influence medication activity? - Answers -If
hepatic sys is compromised, subjective to alcoholism, regular use of recreational drugs,
& hepatitis (some type of hepatic infec) than the CP450 will NOT yield the expected
results. We'll have TOO MUCH active drug floating around (drug toxicity)
What is the first-pass effect? What should the nurse monitor? - Answers -Hepatic
inactivation of medication by CYP450.
What is a generic name medications? - Answers -the nonproprietary name that is
given by the United States Adopted Names Council. Each medication has only one
generic name.
What is a trade name medications? - Answers -is the brand or proprietary name given
by the company that manufactures the medication. One medication may have multiple
trade names.
What are the four components of pharmacokinetics? - Answers -absorption,
distribution, metabolism, excretion
What is absorption? - Answers -transmission of meds from location of admin to
bloodstream.
What is distribution? - Answers -the movement of drugs throughout the body
What is metabolism (biotransformation)? - Answers -The enzymatic alteration of drug
structure, most often takes place in the liver
What is excretion? - Answers -The removal of drugs from the body; can exit body
through urine, sweat, saliva, breast milk and expired air
What factors influence distribution? - Answers -Circulation: conditions that stop blood
flow/perfusion (peripheral vascular/cardiac disease)
Permeability of cell membrane: meds must be able to pass through tissues/membranes
to reach target area; meds that are lipid-soluble or have a transport system can cross
the blood-brain barrier and the placenta
Plasma protein binding: meds compete for protein binding sites within blood stream
(primarily albumin.
How do alterations influence target cells? - Answers -Plasma protein binding: meds
compete for protein binding sites within blood stream (primarily albumin. The ability of a
med to bind to protein can affect how much medication will leave/travel to target tissues.
Two meds can compete for same binding site resulting in toxicity.
How do enterohepatic complications influence medication activity? - Answers -If
hepatic sys is compromised, subjective to alcoholism, regular use of recreational drugs,
& hepatitis (some type of hepatic infec) than the CP450 will NOT yield the expected
results. We'll have TOO MUCH active drug floating around (drug toxicity)
What is the first-pass effect? What should the nurse monitor? - Answers -Hepatic
inactivation of medication by CYP450.
