NUR 521- Module 1/Test 1 Questions with Correct Answers Verified by Experts|
Latest Update
Why do we monitor drug therapy? - Determining therapeutic dosage
- Evaluating medication adequacy
- Identifying adverse effects
- Narrow Therapeutic index (NTI): difference between effective and lethal dose is small
What are reasons that patient's will not take their medications? How can you address these as
a provider? - Forgetfulness
- lack of planning
- cost
- dissatisfaction
- altered dosing
drug movement from site of administration into the blood Absorption
- rate of absorption is how fast effects take place
movement from the blood to the interstitial space of tissues and from there into the cells and
to the site of action Distribution
_______________ is determined by the blood flow to tissues, the ability of a drug to exit the
vascular system, and to a lesser extent the ability of a drug to enter cells distribution
breaking down of the drug/ enzymatic process that occurs in the liver Metabolism
(biotransformation)
P450 refers to cytochrome P450
Drugs that increase the rate of drug metabolism inducers
, Drugs that decrease the rate of drug metabolism inhibitors
the movement of drugs and their metabolites out of the body Excretion
Combination of metabolism and excretion is called _____________ Elimination
______________ refers to the amount of an active drug that reaches the systemic circulation
from its site of administration. Bioavailability
What are some factors that can affect bioavailability - Different formulations of the same
drug can vary in bioavailability
binders and fillers
Factors such as
- tablet disintegration time
- enteric coatings
- sustained-release formulations
can alter bioavailability and can thereby make drug responses variable.
When are drugs equal in bioavailability? if the drug they contain is absorbed at the same
rate and to the same extent
T/F: It is possible for two formulations of the same drug to be chemically equivalent while
differing in bioavailability. True
Latest Update
Why do we monitor drug therapy? - Determining therapeutic dosage
- Evaluating medication adequacy
- Identifying adverse effects
- Narrow Therapeutic index (NTI): difference between effective and lethal dose is small
What are reasons that patient's will not take their medications? How can you address these as
a provider? - Forgetfulness
- lack of planning
- cost
- dissatisfaction
- altered dosing
drug movement from site of administration into the blood Absorption
- rate of absorption is how fast effects take place
movement from the blood to the interstitial space of tissues and from there into the cells and
to the site of action Distribution
_______________ is determined by the blood flow to tissues, the ability of a drug to exit the
vascular system, and to a lesser extent the ability of a drug to enter cells distribution
breaking down of the drug/ enzymatic process that occurs in the liver Metabolism
(biotransformation)
P450 refers to cytochrome P450
Drugs that increase the rate of drug metabolism inducers
, Drugs that decrease the rate of drug metabolism inhibitors
the movement of drugs and their metabolites out of the body Excretion
Combination of metabolism and excretion is called _____________ Elimination
______________ refers to the amount of an active drug that reaches the systemic circulation
from its site of administration. Bioavailability
What are some factors that can affect bioavailability - Different formulations of the same
drug can vary in bioavailability
binders and fillers
Factors such as
- tablet disintegration time
- enteric coatings
- sustained-release formulations
can alter bioavailability and can thereby make drug responses variable.
When are drugs equal in bioavailability? if the drug they contain is absorbed at the same
rate and to the same extent
T/F: It is possible for two formulations of the same drug to be chemically equivalent while
differing in bioavailability. True
