Test bank for Tietz Fundamentals of Clinical Chemistry an
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Molecular Diagnostics,
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8th Edition by Nader Rifai, PhD
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Chapters 1 - 49
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,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
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Table of contents:
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I. Principles Of Laboratory Medicine
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Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
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Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
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Chapter 3. Clinical Evaluation of Methods
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Chapter 4. Evidence-Based Laboratory Medicine
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Chapter 5. Establishment and Use of Reference Values
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Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
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Chapter 7. Quality Management
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II. Analytical Techniques And Instrumentation
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Chapter 8. Principles of Basic Techniques and Laboratory Safety
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Chapter 9. Optical Techniques
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Chapter 10. Electrochemistry and Chemical Sensors
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Chapter 11. Electrophoresis
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Chapter 12. Chromatography
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Chapter 13. Mass Spectrometry
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Chapter 14. Enzyme and Rate Analyses
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Chapter 15. Immunochemical Techniques
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Chapter 16 Automation
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Chapter 17. Point-of-Care Instrumentation
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III. Analytes
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Chapter 18. Amino Acids, Peptides, and Proteins
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Chapter 19. Serum Enzymes
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Chapter 20. Tumor Markers and Cancer Genes
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Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
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Chapter 22. Carbohydrates
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Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
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Chapter 24. Electrolytes and Blood Gases
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Chapter 25. Hormones
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Chapter 26. Catecholamines and Serotonin
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Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
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Chapter 28. Hemoglobin, Iron, and Bilirubin
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Chapter 29. Porphyrins and Porphyrias
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Chapter 30. Therapeutic Drugs and Their Management
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Chapter 31. Clinical Toxicology
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Chapter 32. Toxic Metals
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IV. Pathophysiology
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Chapter 33. Diabetes
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,Chapter 34. Cardiovascular Disease
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Chapter 35. Kidney Disease
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Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
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Chapter 37. Liver Disease
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Chapter 38. Gastrointestinal and Pancreatic Diseases
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Chapter 39. Disorders of Bone and Mineral Metabolism
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Chapter 40. Disorders of the Pituitary Gland
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Chapter 41. Disorders of the Adrenal Cortex
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Chapter 42. Thyroid Disorders
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Chapter 43. Reproduction-Related Disorders
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Chapter 44. Pregnancy and Prenatal Testing
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Chapter 45. Newborn Screening and Inborn Errors of Metabolism
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Chapter 46. Pharmacogenetics
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V. Molecular Diagnostics
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Chapter 47. Principles of Molecular Biology
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Chapter 48. Nucleic Acid Techniques and Applications
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Chapter 49. Genomes and Nucleic Acid Alterations
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, Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
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TestBank
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MULTIPLE CHOICE q
1. An individual working in a clinical chemistry laboratory is married to a sales representative
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who works for a company that sells chemistry laboratory supplies. When the laboratory
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manager requests a list of needed supplies, cost of supplies, and vendors, this individual
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onlyrecommends the spouse’s company as the vendor. This is considered to be a(n):
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a. accounting issue. q
b. possible conflict of interest. q q q
c. maintenance of confidentiality issue. q q q
d. problem with resource allocation. q q q
ANS: B q
Concern has been raised over the interrelationships between practitioners in the medical
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fieldand commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
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Similarly, relationships have been scrutinized between clinical laboratorians and
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manufacturers and providers of diagnostic equipment and supplies. These concerns led the
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National Institutes of Health (NIH) in 1995 to require official institutional review of financial
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disclosure by researchers and management of situations in which disclosure indicates
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potentialconflicts of interest.
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DIF: 1 REF: Page 4-5 qqq q OBJ: 6 | 7 q q q
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce
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the pain following her recent surgery. A friend of the patient claims that the same
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painkiller―worked wonders‖ to reduce her pain after the same surgery. The physician
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states that the difference in the effect of the drug might be caused by , which is studied
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in pharmacogenetics.
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a. epidemiology
b. an inherited disease q q
c. a conflict of interest
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d. a genetic variation in drug-metabolizing enzymes
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ANS: D q
Pharmacogenetics is the study of the genetic variation of drug metabolism q q q q q q q q q q
betweenindividuals.
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DIF: 1 REF: Page 3 qqq q OBJ: 1 q
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the
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name of a close friend printed on the bar-coded label. The genetic test that is ordered on
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thefriend’s sample would provide diagnostic information about a disorder that has a poor
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prognosis, and the test is usually performed by John. He asks a fellow employee to
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analyzethe sample for him and not divulge the results. This ethical issue concerns:
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a. confidentiality of patient genetic and medical information. q q q q q q
b. a conflict of interest.
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c. resource allocation. q
d. diagnostic accuracy. q
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Molecular Diagnostics,
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8th Edition by Nader Rifai, PhD
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Chapters 1 - 49
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,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
q q q q q q q q
q
q q
Table of contents:
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I. Principles Of Laboratory Medicine
q q q q
Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
q q q q q q q q
Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
q q q q q q q q q q q
Chapter 3. Clinical Evaluation of Methods
q q q q q
Chapter 4. Evidence-Based Laboratory Medicine
q q q q
Chapter 5. Establishment and Use of Reference Values
q q q q q q q
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
q q q q q q q q
Chapter 7. Quality Management
q q q
II. Analytical Techniques And Instrumentation
q q q q
Chapter 8. Principles of Basic Techniques and Laboratory Safety
q q q q q q q q
Chapter 9. Optical Techniques
q q q
Chapter 10. Electrochemistry and Chemical Sensors
q q q q q
Chapter 11. Electrophoresis
q q
Chapter 12. Chromatography
q q
Chapter 13. Mass Spectrometry
q q q
Chapter 14. Enzyme and Rate Analyses
q q q q q
Chapter 15. Immunochemical Techniques
q q q
Chapter 16 Automation
q q
Chapter 17. Point-of-Care Instrumentation
q q q
III. Analytes
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Chapter 18. Amino Acids, Peptides, and Proteins
q q q q q q
Chapter 19. Serum Enzymes
q q q
Chapter 20. Tumor Markers and Cancer Genes
q q q q q q
Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
q q q q q q q q q q q
Chapter 22. Carbohydrates
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Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
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Chapter 24. Electrolytes and Blood Gases
q q q q q
Chapter 25. Hormones
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Chapter 26. Catecholamines and Serotonin
q q q q
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
q q q q q q
Chapter 28. Hemoglobin, Iron, and Bilirubin
q q q q q
Chapter 29. Porphyrins and Porphyrias
q q q q
Chapter 30. Therapeutic Drugs and Their Management
q q q q q q
Chapter 31. Clinical Toxicology
q q q
Chapter 32. Toxic Metals
q q q
IV. Pathophysiology
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Chapter 33. Diabetes
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,Chapter 34. Cardiovascular Disease
q q q
Chapter 35. Kidney Disease
q q q
Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
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Chapter 37. Liver Disease
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Chapter 38. Gastrointestinal and Pancreatic Diseases
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Chapter 39. Disorders of Bone and Mineral Metabolism
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Chapter 40. Disorders of the Pituitary Gland
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Chapter 41. Disorders of the Adrenal Cortex
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Chapter 42. Thyroid Disorders
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Chapter 43. Reproduction-Related Disorders
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Chapter 44. Pregnancy and Prenatal Testing
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Chapter 45. Newborn Screening and Inborn Errors of Metabolism
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Chapter 46. Pharmacogenetics
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V. Molecular Diagnostics
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Chapter 47. Principles of Molecular Biology
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Chapter 48. Nucleic Acid Techniques and Applications
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Chapter 49. Genomes and Nucleic Acid Alterations
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, Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
q q q q q q q q
TestBank
q q
MULTIPLE CHOICE q
1. An individual working in a clinical chemistry laboratory is married to a sales representative
q q q q q q q q q q q q q
who works for a company that sells chemistry laboratory supplies. When the laboratory
q q q q q q q q q q q q q
manager requests a list of needed supplies, cost of supplies, and vendors, this individual
q q q q q q q q q q q q q q
onlyrecommends the spouse’s company as the vendor. This is considered to be a(n):
q q q q q q q q q q q q q q
a. accounting issue. q
b. possible conflict of interest. q q q
c. maintenance of confidentiality issue. q q q
d. problem with resource allocation. q q q
ANS: B q
Concern has been raised over the interrelationships between practitioners in the medical
q q q q q q q q q q q
fieldand commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
q q q q q q q q q q q q q
Similarly, relationships have been scrutinized between clinical laboratorians and
q q q q q q q q
manufacturers and providers of diagnostic equipment and supplies. These concerns led the
q q q q q q q q q q q q
National Institutes of Health (NIH) in 1995 to require official institutional review of financial
q q q q q q q q q q q q q q
disclosure by researchers and management of situations in which disclosure indicates
q q q q q q q q q q q
potentialconflicts of interest.
q q q q
DIF: 1 REF: Page 4-5 qqq q OBJ: 6 | 7 q q q
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce
q q q q q q q q q q q q q q
the pain following her recent surgery. A friend of the patient claims that the same
q q q q q q q q q q q q q q q
painkiller―worked wonders‖ to reduce her pain after the same surgery. The physician
q q q q q q q q q q q q q
states that the difference in the effect of the drug might be caused by , which is studied
q q q q q q q q q q q q q q q q q
in pharmacogenetics.
q q
a. epidemiology
b. an inherited disease q q
c. a conflict of interest
q q q
d. a genetic variation in drug-metabolizing enzymes
q q q q q
ANS: D q
Pharmacogenetics is the study of the genetic variation of drug metabolism q q q q q q q q q q
betweenindividuals.
q q
DIF: 1 REF: Page 3 qqq q OBJ: 1 q
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the
q q q q q q q q q q q q q q
name of a close friend printed on the bar-coded label. The genetic test that is ordered on
q q q q q q q q q q q q q q q q q
thefriend’s sample would provide diagnostic information about a disorder that has a poor
q q q q q q q q q q q q q q
prognosis, and the test is usually performed by John. He asks a fellow employee to
q q q q q q q q q q q q q q q
analyzethe sample for him and not divulge the results. This ethical issue concerns:
q q q q q q q q q q q q q q
a. confidentiality of patient genetic and medical information. q q q q q q
b. a conflict of interest.
q q q
c. resource allocation. q
d. diagnostic accuracy. q
