UNE MEDICAL BIOCHEMISTRY MIDTERM QUESTIONS AND
ANSWERS 2024/2025 A COMPLETE EXAM SOLUTION ALL
ANSWERS GET IT 100% CORRECT VERIFIED BEST GRADED A+
FOR PASS
Which of the following cofactors or coenzymes would not typically participate in an activation transfer
reaction? - CORRECT ANSWERS NADH
Which of the following proteins is likely to have quaternary structure? - CORRECT ANSWERS A
multimeric protein that contains multiple peptide chains
Prosthetic groups are complex nonprotein molecules that participate in catalysis by providing functional
groups that form a covalent intermediate between the enzyme and the substrate. Which of the
following is an example of a coenzyme or cofactor that participates in a covalent catalysis reaction? -
CORRECT ANSWERS Pyridoxal phosphate
Cleavage of fructose 1,6 bisphosphate to dihydroxyacetone and Glyceraldehyde 3-phosphate involves
the breaking of a carbon-carbon bond through a process other than oxidation or hydrolysis. This is
achieved by what class of enzymes? - CORRECT ANSWERS Lyase
Which of the following best describes tertiary structure? - CORRECT ANSWERS Interactions
between alpha helices and beta sheets to form a domain
How do most enzymes reduce the activation energy needed to move a reaction forward? - CORRECT
ANSWERS providing an active site most complementary to the transition state
Which amino acid would not be commonly found in the middle of an alpha-helical domain? -
CORRECT ANSWERS Proline
Which of the following is a true statement with regards to the malate-aspartate shuttle system? -
CORRECT ANSWERS Generates 2.5 molecules of ATP in mitochondria per each NADH from
glycolysis.
, UNE MEDICAL BIOCHEMISTRY MIDTERM QUESTIONS AND
ANSWERS 2024/2025 A COMPLETE EXAM SOLUTION ALL
ANSWERS GET IT 100% CORRECT VERIFIED BEST GRADED A+
FOR PASS
The malate-aspartate shuttle is used to move reducing equivalents o cytosolic NADH into the
mitochondria where it can be oxidized. Which of the following compounds is used to move the reducing
equivalents from cytosolic NADH into the mitochondria? - CORRECT ANSWERS Malate
Which of the following is an example of enzyme regulation through covalent modification? -
CORRECT ANSWERS phosphorylation of muscle glycogen phosphorylase
Under low energy conditions, AMP will bind to phosphofructokinase I and glycogen phosphorylase at
site unique to the active site. This enhances the activity of these enzymes. This is an example of which of
the following types of enzyme regulation? - CORRECT ANSWERS Allosteric activation
A 28 year old male is recently diagnosed with HIV. As part of his treatment he is prescribed Nevirapine
which interferes with retroviral reverse transcript erase enzyme. Use the graph below, which of the
following best describes the impact of this drug on its target? - CORRECT ANSWERS It reduces
the catalytic activity of the enzyme.
In the image below, the blue line indicates enzyme kinetics with no inhibitor present. Based on this
information which of the following is true? - CORRECT ANSWERS The green line shows enzyme
kinetics with the addition of a noncompetitive inhibitor.
The following represents a series of reactions. As levels of B increase, this will decrease the conversion
of S3 to B. Which of the following best describes this type of regulation in a biosynthetic pathway? -
CORRECT ANSWERS Feedback inhibition
An example of enzyme activation by cleavage is best illustrated by which of the following? - CORRECT
ANSWERS Activation of chymotrypsinogen to chymotrpysin
A teenage female presenting with lack of menstruation (amenorrhea) is found to have dysfunctional
steroid receptor characteristic of androgen insensitivity syndrome. Which of the following statements
accurately describes steroid hormones? - CORRECT ANSWERS The enhance transcription when
bound to receptors.
ANSWERS 2024/2025 A COMPLETE EXAM SOLUTION ALL
ANSWERS GET IT 100% CORRECT VERIFIED BEST GRADED A+
FOR PASS
Which of the following cofactors or coenzymes would not typically participate in an activation transfer
reaction? - CORRECT ANSWERS NADH
Which of the following proteins is likely to have quaternary structure? - CORRECT ANSWERS A
multimeric protein that contains multiple peptide chains
Prosthetic groups are complex nonprotein molecules that participate in catalysis by providing functional
groups that form a covalent intermediate between the enzyme and the substrate. Which of the
following is an example of a coenzyme or cofactor that participates in a covalent catalysis reaction? -
CORRECT ANSWERS Pyridoxal phosphate
Cleavage of fructose 1,6 bisphosphate to dihydroxyacetone and Glyceraldehyde 3-phosphate involves
the breaking of a carbon-carbon bond through a process other than oxidation or hydrolysis. This is
achieved by what class of enzymes? - CORRECT ANSWERS Lyase
Which of the following best describes tertiary structure? - CORRECT ANSWERS Interactions
between alpha helices and beta sheets to form a domain
How do most enzymes reduce the activation energy needed to move a reaction forward? - CORRECT
ANSWERS providing an active site most complementary to the transition state
Which amino acid would not be commonly found in the middle of an alpha-helical domain? -
CORRECT ANSWERS Proline
Which of the following is a true statement with regards to the malate-aspartate shuttle system? -
CORRECT ANSWERS Generates 2.5 molecules of ATP in mitochondria per each NADH from
glycolysis.
, UNE MEDICAL BIOCHEMISTRY MIDTERM QUESTIONS AND
ANSWERS 2024/2025 A COMPLETE EXAM SOLUTION ALL
ANSWERS GET IT 100% CORRECT VERIFIED BEST GRADED A+
FOR PASS
The malate-aspartate shuttle is used to move reducing equivalents o cytosolic NADH into the
mitochondria where it can be oxidized. Which of the following compounds is used to move the reducing
equivalents from cytosolic NADH into the mitochondria? - CORRECT ANSWERS Malate
Which of the following is an example of enzyme regulation through covalent modification? -
CORRECT ANSWERS phosphorylation of muscle glycogen phosphorylase
Under low energy conditions, AMP will bind to phosphofructokinase I and glycogen phosphorylase at
site unique to the active site. This enhances the activity of these enzymes. This is an example of which of
the following types of enzyme regulation? - CORRECT ANSWERS Allosteric activation
A 28 year old male is recently diagnosed with HIV. As part of his treatment he is prescribed Nevirapine
which interferes with retroviral reverse transcript erase enzyme. Use the graph below, which of the
following best describes the impact of this drug on its target? - CORRECT ANSWERS It reduces
the catalytic activity of the enzyme.
In the image below, the blue line indicates enzyme kinetics with no inhibitor present. Based on this
information which of the following is true? - CORRECT ANSWERS The green line shows enzyme
kinetics with the addition of a noncompetitive inhibitor.
The following represents a series of reactions. As levels of B increase, this will decrease the conversion
of S3 to B. Which of the following best describes this type of regulation in a biosynthetic pathway? -
CORRECT ANSWERS Feedback inhibition
An example of enzyme activation by cleavage is best illustrated by which of the following? - CORRECT
ANSWERS Activation of chymotrypsinogen to chymotrpysin
A teenage female presenting with lack of menstruation (amenorrhea) is found to have dysfunctional
steroid receptor characteristic of androgen insensitivity syndrome. Which of the following statements
accurately describes steroid hormones? - CORRECT ANSWERS The enhance transcription when
bound to receptors.
