1|Page
UNE MEDICAL BIOCHEMISTRY MIDTERM EXAM LATEST 2025
ACTUAL EXAM WITH COMPLETE QUESTIONS AND CORRECT
DETAILED ANSWERS (100% VERIFIED ANSWERS) |ALREADY
GRADED A+| ||PROFESSOR VERIFIED|| ||BRANDNEW!!!||
A suspected mutation in the cortisol receptor is discovered.
Cortisol can still bind its receptor but the dimerized complex
remains in the cytosol. Based on this description which region on
the receptor is likely impacted? - ANSWER-Nuclear localization
signal
Which of the following pathways provides the primary oxidizable
fuel for skeletal muscle in the fasted state? - ANSWER-Lipolysis
from adipose tissue
After a meal, fructose 2,6-bisphosphate levels are elevated. This
compound will allosterically activate which of the following
glycolytic compounds? - ANSWER-Phosphofructokinase-1 (PFK-
1)
Which of the following best describes the net effect of the 8 steps
of the TCA cycle? - ANSWER-This process completely oxidizes
an acetyl group to carbon dioxide
,2|Page
Which of the following intermediates of the TCA cycle is required
in the cytosol for fatty acid synthesis? - ANSWER-Citrate
In order for glucose to be retained within the cell, which of the
following modifications must occur? - ANSWER-Phosphorylation
Certain metabolic conditions will reduce flux through the TCA
cycle due to an increase in TCA cycle inhibitions. Elevation of
which of the following would be an example of a compound that
will reduce activity through the TCA? - ANSWER-NADH
Elevated levels of glucagon can enhance or inhibit many
processes. Which of the following processes is not impacted by
elevated levels of glucagon? - ANSWER-Skeletal muscle
glycogenolysis
Which of the following events occurs during the formation of
phosphoenolpyruvate from pyruvate during Gluconeogenesis? -
ANSWER-CO2 is required
,3|Page
During an overnight fast, which of the following is the major
source of blood glucose? - ANSWER-Hepatic glycogenolysis
When insulin levels are high, which of the following is true? -
ANSWER-Glycogen synthase is dephosphorylated and active
In the non-oxidative portion of the pentose phosphate pathway, 2-
carbon fragments of kept-sugars can be transferred to other
sugars to generate a large sugar molecule. This reaction is
catalyzed by which of the following enzymes? - ANSWER-
Transketolase
An 18-month old is newly diagnosed with hereditary fructose
intolerance (deficiency of Aldolase B). His mother reports he is
particularly upset when he gets up in the morning or if he has not
eaten in a while. Laboratory testing showed low blood glucose
levels at the time of presentation. This presentation is likely due to
an accumulation of fructose-1-phosphate and inhibition of which
of the following pathways? - ANSWER-Gluconeogenesis and
glycogenolysis
, 4|Page
Which of the following enzymes is involved in the non-oxidative
portion of the Pentose Pathway? - ANSWER-Transaldolase
In the red blood cell, glucose can be oxidized to two primary
products. One of the oxidation products is lactate and the other is
which of the following compounds? - ANSWER-Ribulose 5-
phosphate
Hereditary Fructose Intolerance (HFI) is a rare recessive disorder.
Which of the following is not a consequence of this enzyme
deficiency? - ANSWER-inability to metabolize glucose in skeletal
muscle
Galactose 1-phosphate is initially converted to glucose 1-
phosphate and requires which of the following compounds? -
ANSWER-UDP-glucose
Red blood cells lack mitochondria therefore glucose is primarily
oxidized to ribose and which of the following compounds? -
ANSWER-Lactate
UNE MEDICAL BIOCHEMISTRY MIDTERM EXAM LATEST 2025
ACTUAL EXAM WITH COMPLETE QUESTIONS AND CORRECT
DETAILED ANSWERS (100% VERIFIED ANSWERS) |ALREADY
GRADED A+| ||PROFESSOR VERIFIED|| ||BRANDNEW!!!||
A suspected mutation in the cortisol receptor is discovered.
Cortisol can still bind its receptor but the dimerized complex
remains in the cytosol. Based on this description which region on
the receptor is likely impacted? - ANSWER-Nuclear localization
signal
Which of the following pathways provides the primary oxidizable
fuel for skeletal muscle in the fasted state? - ANSWER-Lipolysis
from adipose tissue
After a meal, fructose 2,6-bisphosphate levels are elevated. This
compound will allosterically activate which of the following
glycolytic compounds? - ANSWER-Phosphofructokinase-1 (PFK-
1)
Which of the following best describes the net effect of the 8 steps
of the TCA cycle? - ANSWER-This process completely oxidizes
an acetyl group to carbon dioxide
,2|Page
Which of the following intermediates of the TCA cycle is required
in the cytosol for fatty acid synthesis? - ANSWER-Citrate
In order for glucose to be retained within the cell, which of the
following modifications must occur? - ANSWER-Phosphorylation
Certain metabolic conditions will reduce flux through the TCA
cycle due to an increase in TCA cycle inhibitions. Elevation of
which of the following would be an example of a compound that
will reduce activity through the TCA? - ANSWER-NADH
Elevated levels of glucagon can enhance or inhibit many
processes. Which of the following processes is not impacted by
elevated levels of glucagon? - ANSWER-Skeletal muscle
glycogenolysis
Which of the following events occurs during the formation of
phosphoenolpyruvate from pyruvate during Gluconeogenesis? -
ANSWER-CO2 is required
,3|Page
During an overnight fast, which of the following is the major
source of blood glucose? - ANSWER-Hepatic glycogenolysis
When insulin levels are high, which of the following is true? -
ANSWER-Glycogen synthase is dephosphorylated and active
In the non-oxidative portion of the pentose phosphate pathway, 2-
carbon fragments of kept-sugars can be transferred to other
sugars to generate a large sugar molecule. This reaction is
catalyzed by which of the following enzymes? - ANSWER-
Transketolase
An 18-month old is newly diagnosed with hereditary fructose
intolerance (deficiency of Aldolase B). His mother reports he is
particularly upset when he gets up in the morning or if he has not
eaten in a while. Laboratory testing showed low blood glucose
levels at the time of presentation. This presentation is likely due to
an accumulation of fructose-1-phosphate and inhibition of which
of the following pathways? - ANSWER-Gluconeogenesis and
glycogenolysis
, 4|Page
Which of the following enzymes is involved in the non-oxidative
portion of the Pentose Pathway? - ANSWER-Transaldolase
In the red blood cell, glucose can be oxidized to two primary
products. One of the oxidation products is lactate and the other is
which of the following compounds? - ANSWER-Ribulose 5-
phosphate
Hereditary Fructose Intolerance (HFI) is a rare recessive disorder.
Which of the following is not a consequence of this enzyme
deficiency? - ANSWER-inability to metabolize glucose in skeletal
muscle
Galactose 1-phosphate is initially converted to glucose 1-
phosphate and requires which of the following compounds? -
ANSWER-UDP-glucose
Red blood cells lack mitochondria therefore glucose is primarily
oxidized to ribose and which of the following compounds? -
ANSWER-Lactate
