and Molecular Diagnostics,
8th Edition by Nader Rifai, PhD
Chapters 1 - 49
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
ED ED ED ED ED ED ED ED
E D
ED ED
Table of contents: ED ED
I. Principles Of Laboratory Medicine
ED ED ED ED
Chapter 1. Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine
ED ED ED ED ED ED ED ED
Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
ED ED ED ED ED ED ED ED ED ED ED
Chapter 3. Clinical Evaluation of Methods
ED ED ED ED ED
Chapter 4. Evidence-Based Laboratory Medicine
ED ED ED ED
Chapter 5. Establishment and Use of Reference Values
ED ED ED ED ED ED ED
Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
ED ED ED ED ED ED ED ED
Chapter 7. Quality Management
ED ED ED
II. Analytical Techniques And Instrumentation
ED ED ED ED
Chapter 8. Principles of Basic Techniques and Laboratory Safety
ED ED ED ED ED ED ED ED
Chapter 9. Optical Techniques
ED ED ED
Chapter 10. Electrochemistry and Chemical Sensors
ED ED ED ED ED
Chapter 11. Electrophoresis
ED ED
Chapter 12. Chromatography
ED ED
Chapter 13. Mass Spectrometry
ED ED ED
Chapter 14. Enzyme and Rate Analyses
ED ED ED ED ED
Chapter 15. Immunochemical Techniques
ED ED ED
Chapter 16 Automation ED ED
Chapter 17. Point-of-Care Instrumentation
ED ED ED
III. Analytes
E D
Chapter 18. Amino Acids, Peptides, and Proteins
ED ED ED ED ED ED
Chapter 19. Serum EnzymesED ED ED
Chapter 20. Tumor Markers and Cancer Genes
ED ED ED ED ED ED
Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
ED ED ED ED ED ED ED ED ED ED ED
Chapter 22. CarbohydratesED ED
Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
ED ED ED ED ED ED ED ED ED
Chapter 24. Electrolytes and Blood Gases
ED ED ED ED ED
Chapter 25. Hormones ED ED
Chapter 26. Catecholamines and Serotonin
ED E D ED ED
Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
ED E D ED ED ED ED
Chapter 28. Hemoglobin, Iron, and Bilirubin
ED ED ED ED ED
Chapter 29. Porphyrins and Porphyrias
ED ED ED ED
Chapter 30. Therapeutic Drugs and Their Management
ED ED ED ED ED ED
Chapter 31. Clinical Toxicology
ED ED ED
Chapter 32. Toxic Metals ED E D ED
IV. Pathophysiology
E D
Chapter 33. Diabetes ED ED
,Chapter 34. Cardiovascular Disease
ED E D ED
Chapter 35. Kidney Disease
ED ED ED
Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
ED E D ED ED ED ED ED ED ED ED
Chapter 37. Liver Disease
ED EDED ED
Chapter 38. Gastrointestinal and Pancreatic Diseases
ED E D ED ED ED
Chapter 39. Disorders of Bone and Mineral Metabolism
ED EDED ED ED ED ED ED
Chapter 40. Disorders of the Pituitary Gland
ED EDED ED ED ED ED
Chapter 41. Disorders of the Adrenal Cortex
ED E D ED ED ED ED
Chapter 42. Thyroid Disorders
ED E D ED
Chapter 43. Reproduction-Related Disorders
ED E D ED
Chapter 44. Pregnancy and Prenatal Testing
ED EDED ED ED ED
Chapter 45. Newborn Screening and Inborn Errors of Metabolism
ED E D ED ED ED ED ED ED
Chapter 46. Pharmacogenetics
ED ED
V. Molecular Diagnostics
E D ED
Chapter 47. Principles of Molecular Biology
ED ED ED ED ED
Chapter 48. Nucleic Acid Techniques and Applications
ED ED ED ED ED ED
Chapter 49. Genomes and Nucleic Acid Alterations
ED ED ED ED ED ED
, Chapter 01: Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine TestBank
ED ED ED ED ED ED ED ED ED E
D
MULTIPLE CHOICE ED
1. An individual working in a clinical chemistry laboratory is married to a sales representative wh
ED ED ED ED ED ED ED ED ED ED ED ED ED ED
o works for a company that sells chemistry laboratory supplies. When the laboratory manager
ED ED ED ED ED ED ED ED ED ED ED ED ED E
requests a list of needed supplies, cost of supplies, and vendors, this individual onlyrecommen
D ED ED ED ED ED ED ED ED ED ED ED ED ED DE
ds the spouse’s company as the vendor. This is considered to be a(n):
ED ED ED ED ED ED ED ED ED ED ED ED
a. accounting issue. ED
b. possible conflict of interest. ED ED ED
c. maintenance of confidentiality issue. ED ED ED
d. problem with resource allocation. ED ED ED
ANS: B E D
Concern has been raised over the interrelationships between practitioners in the medical field
ED ED ED ED ED ED ED ED ED ED ED ED DE
and commercial suppliers of drugs, devices, equipment, etc., to the medical profession.
ED ED ED ED ED ED ED ED ED ED ED
Similarly, relationships have been scrutinized between clinical laboratorians and manufacturer
ED ED ED ED ED ED ED ED ED
s and providers of diagnostic equipment and supplies. These concerns led the National Institute
ED ED ED ED ED ED ED ED ED ED ED ED ED
s of Health (NIH) in 1995 to require official institutional review of financial disclosure by researc
ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED
hers and management of situations in which disclosure indicates potentialconflicts of interest.
ED ED ED ED ED ED ED ED ED DE ED ED
DIF: 1 REF: Page 4-5 EDEDED ED OBJ: 6 | 7 E D ED ED
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce th
ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED
e pain following her recent surgery. A friend of the patient claims that the same painkiller“wo
ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED DE
rked wonders” to reduce her pain after the same surgery. The physician states that the differ
ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED
ence in the effect of the drug might be caused by
ED ED ED ED ED ED ED ED ED ED
, which is studied in pharmacogenetics.
ED ED ED ED ED
a. epidemiology
b. an inherited disease ED ED
c. a conflict of interest ED ED ED
d. a genetic variation in drug-metabolizing enzymes
ED ED ED ED ED
ANS: D E D
Pharmacogenetics is the study of the genetic variation of drug metabolism betweeni ED ED ED ED ED ED ED ED ED ED ED DE
ndividuals.
DIF: 1 REF: Page 3 EDEDE D ED OBJ: 1 E D
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the na
ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED
me of a close friend printed on the bar-
ED ED ED ED ED ED ED ED
coded label. The genetic test that is ordered on thefriend’s sample would provide diagnostic i
ED ED ED ED ED ED ED ED ED DE ED ED ED ED ED
nformation about a disorder that has a poor prognosis, and the test is usually performed by J ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED
ohn. He asks a fellow employee to analyzethe sample for him and not divulge the results. This
ED ED ED ED ED ED ED DE ED ED ED ED ED ED ED ED ED
ethical issue concerns:
ED ED ED
a. confidentiality of patient genetic and medical information. ED ED ED ED ED ED
b. a conflict of interest. ED ED ED
c. resource allocation. ED
d. diagnostic accuracy. ED