DBB TEST 5 QUESTIONS WITH DETAILED
VERIFIED ANSWERS
Biotransformation of drugs in the liver often occur in two stages; phase 1 changes are ____
and include _____
non-synthetic; oxidation
Which of the following procedures would be used for quantifying molecules in various
body fluids and tissue extracts from known samples
radioimmunoassay
This image shows a graphical display of mutant mice performing on a locomotion task.
Which mutation has occurs and what is the explanation for locomotion differences between
the control and the mutant?
Dopamine receptor 1; mutant mouse has reduced locomotion and is less sensitive to cocaine
treatment
This pathway shows catecholamine synthesis. Enzyme A is called ______ and is considered
a ______and enzyme B is needed to produce ___
tyrosine hydroxylase; rate limiting step; NE
This table shows drugs that affect the DA system. Box B (SKF38393) _____ D1 receptors
while box C is a drug that ______ D2 receptors. Additionally, haloperidol can cause ______
in rodents.
stimulates; blocks; catalepsy
Dopaminergic cell bodies in the VTA send projections to the nucleus accumbens and the
amygdala via the ____ dopamine pathway.
mesolimbic
In radio ligand binding studies, _____ represents the number of binding sites and ___ is an
indication of receptor affinity.
,Bmax; Kd
Which of the following about MDMA is false?
It has definitively been shown to produce degeneration of nerve fibers in all human users.
The least efficacious dug in this dose response curve is
aspirin
In the passive avoidance learning paradigm, learning is demonstrated by
increased latency to enter the dark compartment.
he pre-training administration of 8-OH-DPAT impairs memory in the one-trial fear
conditioning protocol, while injection just after training has no effect.
One interpretation of this finding is that stimulation of hippocampal 5-HT1A receptors
hyperpolarizes neurons normally activated during memory encoding.
Epigenetic changes affect gene expression by
DNA methylation; chromatin remodeling
Using the figure below, determine which organ would be inserted in box (4);
liver
The sac-like structures in the presynaptic terminal are called ____ and are filled with ____
synaptic vesicles; NT molecules
Binding of neurotropic factors to their respective trk receptors results in the
Reciprocal phosphorylation of the two receptor molecules
Knockout mice lacking the serotonin transporter SERT exhibit all of the following except
for
enhanced maternal behavior
Anti-migraine drugs known as trip tans act as ______ agonsist and cause ____ of blood
vessels
, 5HT1b/1D; constriction
After drug administration has occurs, the amount of drug in the blood tat is free to bind at
specific target sites is referred to as
bioavailability
Evidence that serotonergic abnormalities may be involved in sudden infant death
syndrome comes from studies showing that
mutant mice deficient in 5-HT2a receptors have trouble breathing
The area postrema and the median emencement represent area in the brain where ____ is
not complete
The BBB
Figure B is unique because
capillaries in the blood brain barrier have tight junctions
In one study, mice that were genetically engineered to express R6/2 (Huntington's)
exhibited motor disturbance that ______over time and these mice also showed a _____
worsened; shortened life span
Hypertension and _____ can be treated with B-receptor agonists
anxiety
The ______ administration of oxytocin has been proposed as a treatment for autism
intranasal
MDMA has recently been shown to improve the clinical response in patients undergoing
treatment for
PTSD
Which of the following describes the interaction of two drugs when the combined drug
effects are greater than would be predicted from that combination?
VERIFIED ANSWERS
Biotransformation of drugs in the liver often occur in two stages; phase 1 changes are ____
and include _____
non-synthetic; oxidation
Which of the following procedures would be used for quantifying molecules in various
body fluids and tissue extracts from known samples
radioimmunoassay
This image shows a graphical display of mutant mice performing on a locomotion task.
Which mutation has occurs and what is the explanation for locomotion differences between
the control and the mutant?
Dopamine receptor 1; mutant mouse has reduced locomotion and is less sensitive to cocaine
treatment
This pathway shows catecholamine synthesis. Enzyme A is called ______ and is considered
a ______and enzyme B is needed to produce ___
tyrosine hydroxylase; rate limiting step; NE
This table shows drugs that affect the DA system. Box B (SKF38393) _____ D1 receptors
while box C is a drug that ______ D2 receptors. Additionally, haloperidol can cause ______
in rodents.
stimulates; blocks; catalepsy
Dopaminergic cell bodies in the VTA send projections to the nucleus accumbens and the
amygdala via the ____ dopamine pathway.
mesolimbic
In radio ligand binding studies, _____ represents the number of binding sites and ___ is an
indication of receptor affinity.
,Bmax; Kd
Which of the following about MDMA is false?
It has definitively been shown to produce degeneration of nerve fibers in all human users.
The least efficacious dug in this dose response curve is
aspirin
In the passive avoidance learning paradigm, learning is demonstrated by
increased latency to enter the dark compartment.
he pre-training administration of 8-OH-DPAT impairs memory in the one-trial fear
conditioning protocol, while injection just after training has no effect.
One interpretation of this finding is that stimulation of hippocampal 5-HT1A receptors
hyperpolarizes neurons normally activated during memory encoding.
Epigenetic changes affect gene expression by
DNA methylation; chromatin remodeling
Using the figure below, determine which organ would be inserted in box (4);
liver
The sac-like structures in the presynaptic terminal are called ____ and are filled with ____
synaptic vesicles; NT molecules
Binding of neurotropic factors to their respective trk receptors results in the
Reciprocal phosphorylation of the two receptor molecules
Knockout mice lacking the serotonin transporter SERT exhibit all of the following except
for
enhanced maternal behavior
Anti-migraine drugs known as trip tans act as ______ agonsist and cause ____ of blood
vessels
, 5HT1b/1D; constriction
After drug administration has occurs, the amount of drug in the blood tat is free to bind at
specific target sites is referred to as
bioavailability
Evidence that serotonergic abnormalities may be involved in sudden infant death
syndrome comes from studies showing that
mutant mice deficient in 5-HT2a receptors have trouble breathing
The area postrema and the median emencement represent area in the brain where ____ is
not complete
The BBB
Figure B is unique because
capillaries in the blood brain barrier have tight junctions
In one study, mice that were genetically engineered to express R6/2 (Huntington's)
exhibited motor disturbance that ______over time and these mice also showed a _____
worsened; shortened life span
Hypertension and _____ can be treated with B-receptor agonists
anxiety
The ______ administration of oxytocin has been proposed as a treatment for autism
intranasal
MDMA has recently been shown to improve the clinical response in patients undergoing
treatment for
PTSD
Which of the following describes the interaction of two drugs when the combined drug
effects are greater than would be predicted from that combination?
