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RN Adult Medical-Surgical Nursing – Edition 12.0 | 2025/2026 – Verified Questions and Correct Answers with Rationales

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This document features verified questions and correct answers based on Edition 12.0 of the RN Adult Medical-Surgical Nursing curriculum, updated for the 2025/2026 academic year. It covers essential content areas such as cardiovascular, respiratory, gastrointestinal, endocrine, musculoskeletal, renal, and neurological systems, as well as critical care concepts and nursing interventions. Ideal for students preparing for ATI exams and the NCLEX-RN.

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Institution
RN Adult Medical-Surgical Nursing Edition 12.0
Course
RN Adult Medical-Surgical Nursing Edition 12.0

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RN Adult Medical-Surgical Nursing – Edition
12.0
ATI Nursing Education


Your essential guide to core medical-surgical nursing content, aligned with
current NCLEX-RN® test plans.

This resource includes:
Comprehensive coverage of adult medical-surgical conditions
Evidence-based nursing interventions and clinical reasoning
Charts, illustrations, and care priorities for quick reference
NCLEX-style practice questions with answers and rationales
Content assessments to track understanding and retention

,1 Introduction
The RN Adult Medical-Surgical Nursing – Edition 12.0 by ATI Nursing Education is a com-
prehensive resource designed to prepare nursing students and professionals for the NCLEX-
RN® exam and clinical practice. This guide provides in-depth coverage of adult medical-
surgical conditions, emphasizing evidence-based nursing interventions, clinical reasoning,
and patient-centered care. It includes quick-reference tools such as charts and care prior-
ities, NCLEX-style practice questions with detailed rationales, and content assessments to
reinforce learning and identify areas for improvement. Aligned with the current NCLEX-RN
test plan, this resource supports the development of critical thinking and clinical judgment
skills essential for managing complex medical-surgical conditions.


2 Quick-Reference Charts and Care Priorities

2.1 Cardiovascular Disorders: Acute Myocardial Infarction (AMI)

Key Assessment Find- Nursing Interventions
ings
Chest pain (crushing, Administer MONA (Morphine, Oxygen, Ni-
radiating) troglycerin, Aspirin) per protocol
ST elevation on ECG Obtain 12-lead ECG within 10 minutes
Diaphoresis, nausea, Monitor vital signs and oxygen saturation ev-
dyspnea ery 15 minutes


Care Priority: Ensure timely reperfusion therapy (e.g., percutaneous coronary intervention)
within 90 minutes to restore coronary blood flow.


2.2 Respiratory Disorders: Pneumonia

Key Assessment Find- Nursing Interventions
ings
Fever, productive Administer antibiotics within 4 hours of di-
cough agnosis
Crackles, tachypnea Encourage incentive spirometry every 2
hours




1

, Hypoxemia (SpO2 < Apply oxygen to maintain SpO2 � 95%
95%)


Care Priority: Promote airway clearance and oxygenation to prevent respiratory failure.


2.3 Gastrointestinal Disorders: Acute Pancreatitis

Key Assessment Find- Nursing Interventions
ings
Epigastric pain radi- Maintain NPO status to rest the pancreas
ating to back
Elevated amy- Administer IV fluids to correct hypovolemia
lase/lipase
Nausea, vomiting Monitor for signs of hypocalcemia
(Chvostek’s sign)


Care Priority: Manage pain and prevent complications like hypovolemic shock.


3 NCLEX-Style Practice Questions and Rationales
Question 1
A nurse is caring for a client with acute myocardial infarction. Which finding requires im-
mediate intervention?


A. Blood pressure 140/90 mm Hg
B. ST elevation on ECG
C. Chest pain rated 4/10
D. Heart rate 88 bpm
Correct Answer:
B. ST elevation on ECG
Rationale:
ST elevation (B) indicates acute myocardial ischemia, requiring immediate reperfusion ther-
apy (e.g., PCI). Hypertension (A) and moderate pain (C) are managed secondarily, and a
heart rate of 88 bpm (D) is within normal limits.



2

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Institution
RN Adult Medical-Surgical Nursing Edition 12.0
Course
RN Adult Medical-Surgical Nursing Edition 12.0

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Uploaded on
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