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Instrumental Analysis – Exam 1 Questions with Verified Answers – Analytical Chemistry Principles, Mass Spectrometry, and Chromatographic Fundamentals

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This document presents a comprehensive and verified set of Exam 1 questions and answers for Instrumental Analysis, covering foundational analytical chemistry methods and instrumentation. Topics include qualitative vs quantitative analysis, interferences (additive, multiplicative, chemical, physical), chromatography principles (retention factor, isotherms, plate theory), calibration techniques, mass spectrometry components and ionization methods (EI, CI, ESI, MCP, TOF, Orbitrap), and system types (open, closed). Ideal for building a solid conceptual framework in both classical and instrumental analytical techniques.

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Instrumental Analysis
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Institution
Instrumental Analysis
Course
Instrumental Analysis

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Uploaded on
June 6, 2025
Number of pages
11
Written in
2024/2025
Type
Exam (elaborations)
Contains
Questions & answers

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instrumental analysis exam 1 questions with verified
answers
2 that gives quantitative information Ans✓✓✓ volumetric analysis
(titration): measurement of substances based on volumetric
measurement


Gravimetric analysis: determine compounds based on mass


3 components of MS Ans✓✓✓ 1. source of ions
2. mass separation/ analyzer
3. detector


4 qualitative information Ans✓✓✓ Extraction: using properties of
solvents to separate materials in solution


precipitation: solid formed in solution during chemical reaction.


distillation: separating components based on boiling points


chemical tests: prove existence or presence of specific chemical


additive interference Ans✓✓✓ direct effect (look at picture of graph)

, example: pH meters respond to Na+ in addition to H+ can lead to error
w/ high concentration of Na+


analyte Ans✓✓✓ species being studied


analytical chemistry Ans✓✓✓ study of separation, identification, &
quantification of chemical components in a materials


calibration curve Ans✓✓✓ plot of detector response against analyte
concentration


two variables : known & measured response correlated to known


chemical interference Ans✓✓✓ other components interfere w/ results
like:
- other solutes or matrix effects
- pH


chromatogram Ans✓✓✓ graph that shows detectors response as a
function of elution time


chromatography Ans✓✓✓ method od separating components in a
mixture

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