NURS 533 EXAM 1 WITH 100% RATED CORRECT REAL EXAM
QUESTIONS AND CORRECT ANSWERS| GRADED A+ |2025 LATEST
VERSION | 100% VERIFIED
Inherited forms of cancer are __________ mutations are thought to account for approximately
_______% of all adult cancers - (answer)germ line
5-10%
Hereditary diffuse gastric cancer (HDGC) susceptibility syndrome involves germ line mutations
in which gene? What does it encode? - (answer)CDH1 gene that encodes the protein E-cadherin
Hereditary breast & ovarian cancer is more common in which ethnic group? - (answer)More
common in people of Ashkenazi Jewish decent
Women with hereditary breast & ovarian cancer (HBOC) syndrome have a germ line mutation in
which gene? - (answer)Either BRCA1 or BRCA2
Approximately what percent of gastic cancers involves germ line mutations in CDH1 gene? -
(answer)Approximately 3 % of all gastric cancers
Life time risk of developing breast & ovarian cancer is up to _____% (breast) and _____%
(ovarian). - (answer)85%
40%
,HNPCC (Hereditary non-polyposis colorectal cancer), also known as Lynch Syndrome, comes
from a mutation in several genes involved in what function? - (answer)DNA repair
Hallmarks of hereditary cancers (5):
EMBRA - (answer)- Early age on onset: < 40 - 50 years for adult onset cancers
- Multiple primary cancers in a single individual: (breast & ovarian)
- Bilateral cancers in paired organs (breast, kidney)
- Rare presentations of cancer (male with breast cancer)
- Abnormalities known to be linked with ↑ cancer risk—atypical nevi & risk of melanoma
What is one of the most common types of hereditary cancer? - (answer)Breast and ovarian cancer
Familial cancers suggest a clustering of cancers that likely occurred by chance. How is this
explained? - (answer)There may be a combination of genetic and non-genetic (i.e.,
environmental) factors that contributed to the development of cancers within a family. i.e.
smoking, obesity
True or False. In familial cancer, an alteration in a single major gene is typically identified. -
(answer)False. In familial cancer, an alteration in a single major gene is unlikely or not identified
What are four examples of environmental factors that may influence cancer risk? - (answer)Diet,
lifestyle, sun exposure, hormonal responses
What are the three defining characteristics of cancer cells? - (answer)Dysregulated growth - this
factor alone does not cause malignancy; ability to invade and metastasize are of equal
pathophysiologic importance
,Capacity for local invasion
Metastasis
Up to ____% of cancers are linked to environmental factors. - (answer)90%
Bening tumor or malignant tumor?
Slow growth - (answer)Benign tumor
Which population is particularly at risk in developing cancer related to immunologic factors? -
(answer)Kidney transplants - greater risk of developing cancer after having a transplant and
having been on long-term immunosuppression.
Bening tumor or malignant tumor?
Defined capsule - (answer)Benign tumor
Bening tumor or malignant tumor?
Not invasive - (answer)Benign tumor
Bening tumor or malignant tumor?
Well differentiated - resembles tissue from which they arose - (answer)Benign tumor
, Bening tumor or malignant tumor?
Low mitotic index (few dividing cells) - (answer)Benign tumor
Bening tumor or malignant tumor?
Do not metastasize - (answer)Benign tumor
Bening tumor or malignant tumor?
Metastasize - (answer)Malignant tumor
Bening tumor or malignant tumor?
Rapid uncontrolled
growth - (answer)Malignant tumor
Bening tumor or malignant tumor?
Not encapsulated - (answer)Malignant tumor
Bening tumor or malignant tumor?
Invasive - (answer)Malignant tumor
QUESTIONS AND CORRECT ANSWERS| GRADED A+ |2025 LATEST
VERSION | 100% VERIFIED
Inherited forms of cancer are __________ mutations are thought to account for approximately
_______% of all adult cancers - (answer)germ line
5-10%
Hereditary diffuse gastric cancer (HDGC) susceptibility syndrome involves germ line mutations
in which gene? What does it encode? - (answer)CDH1 gene that encodes the protein E-cadherin
Hereditary breast & ovarian cancer is more common in which ethnic group? - (answer)More
common in people of Ashkenazi Jewish decent
Women with hereditary breast & ovarian cancer (HBOC) syndrome have a germ line mutation in
which gene? - (answer)Either BRCA1 or BRCA2
Approximately what percent of gastic cancers involves germ line mutations in CDH1 gene? -
(answer)Approximately 3 % of all gastric cancers
Life time risk of developing breast & ovarian cancer is up to _____% (breast) and _____%
(ovarian). - (answer)85%
40%
,HNPCC (Hereditary non-polyposis colorectal cancer), also known as Lynch Syndrome, comes
from a mutation in several genes involved in what function? - (answer)DNA repair
Hallmarks of hereditary cancers (5):
EMBRA - (answer)- Early age on onset: < 40 - 50 years for adult onset cancers
- Multiple primary cancers in a single individual: (breast & ovarian)
- Bilateral cancers in paired organs (breast, kidney)
- Rare presentations of cancer (male with breast cancer)
- Abnormalities known to be linked with ↑ cancer risk—atypical nevi & risk of melanoma
What is one of the most common types of hereditary cancer? - (answer)Breast and ovarian cancer
Familial cancers suggest a clustering of cancers that likely occurred by chance. How is this
explained? - (answer)There may be a combination of genetic and non-genetic (i.e.,
environmental) factors that contributed to the development of cancers within a family. i.e.
smoking, obesity
True or False. In familial cancer, an alteration in a single major gene is typically identified. -
(answer)False. In familial cancer, an alteration in a single major gene is unlikely or not identified
What are four examples of environmental factors that may influence cancer risk? - (answer)Diet,
lifestyle, sun exposure, hormonal responses
What are the three defining characteristics of cancer cells? - (answer)Dysregulated growth - this
factor alone does not cause malignancy; ability to invade and metastasize are of equal
pathophysiologic importance
,Capacity for local invasion
Metastasis
Up to ____% of cancers are linked to environmental factors. - (answer)90%
Bening tumor or malignant tumor?
Slow growth - (answer)Benign tumor
Which population is particularly at risk in developing cancer related to immunologic factors? -
(answer)Kidney transplants - greater risk of developing cancer after having a transplant and
having been on long-term immunosuppression.
Bening tumor or malignant tumor?
Defined capsule - (answer)Benign tumor
Bening tumor or malignant tumor?
Not invasive - (answer)Benign tumor
Bening tumor or malignant tumor?
Well differentiated - resembles tissue from which they arose - (answer)Benign tumor
, Bening tumor or malignant tumor?
Low mitotic index (few dividing cells) - (answer)Benign tumor
Bening tumor or malignant tumor?
Do not metastasize - (answer)Benign tumor
Bening tumor or malignant tumor?
Metastasize - (answer)Malignant tumor
Bening tumor or malignant tumor?
Rapid uncontrolled
growth - (answer)Malignant tumor
Bening tumor or malignant tumor?
Not encapsulated - (answer)Malignant tumor
Bening tumor or malignant tumor?
Invasive - (answer)Malignant tumor
