NR 547 WEEK 6 SI REVIEW EXAM WITH VERIFIED ANSWERS
1.Genetics jAD: jGenes jplay ja jstrong jrole- jheritability jof j58-79% jfor jlate
jonset jand jover j90% jfor jearly jonset
2.WHAT jARE jTHE jTWO jHALLMARKS jOF jAD?: jamyloid jplaques jand
jneurofibril- jlary jtangles j-•Responsible jfor jissues jwith jmemory jand
jhigher-level jthinking
3.Neural jnetworks jAD: jDamage jto jsynapses, jmitochondrial
jabnormalities, jand jinflammatory jprocesses jcause jNTM jfailure jand
jneuronal jdeath
4.NTM jresponsible jfor jmemory jand jlearning: jACh
5.Does jAD jlead jto jan jincrease jor jdecrease jin jthis jNTM jactivity: jLeads jto
ja jdecrease jin jNTM jactivity
6.Decreased jACh jleads jto: ja jpermanent jloss jof jcholinergic jneurons= jthis
jcauses jshort jterm jmemory jdysfunction
7.Cholinesterase jinhibitors jexamples:
jDonepezil jRivastigmine
Galantamine
8.Cholinesterase jinhibitors: jalleviate jsymptoms, jdo jnot jstop
jprogression jIncrease jlevels jof jACH
Improves jcognition jwhich jimproves jmemory jand jthinking
9.Donepezil j(Aricept): jinhibits jcentrally jactive jACH• jHigher jdoses jcause
jhigher jincidence jof jadverse jeffects
10.Cholinesterase jinhibitors j- jWhat jhappens jwhen jadded jto jCYP2D6 jor j3A4?
1 j/
j19
,: jpossibility jof jperipheral jside jeffects
11.•Rivastigmine j(Exelon): jincreases jefficacy jof jboth
jacetylcholinesterase jand jbutyrylcholinesterase
Medications jthat jreduce jor jinhibit jCYP450 jmetabolism jwill jnot jaffect
jrivastigmine jmetabolism
12.Galantamine j(Razadyne, jRazadyne jER): jelevates jACH jin jthe jcerebral
jcortex jto jincrease jAch jrelease jfrom jexisting jpresynaptic jnerve
jterminals. jAlso jincreases jGlu jand j5HT
Cannot jbe jused jconcurrently jwith jNSAIDS jor jmedications jthat jslow jor
jdecrease jHR.
13.Memantine
N-Methyl-D-Aspartate jReceptor jAntagonist: j•NMDA jreceptor jantagonist
• Only japproved jmedication jto jmanage jmoderate- jsevere jAD
• Works jby jpreventing jglutamate jbinding jat jthe jreceptor jsite jand
jregulates jhow jmuch jcalcium jenters jthe jnerve jcell
• Blocking jNMDA jreceptors jprotects jneurons jfrom jthe jeffects jof jtoo
jmuch jGlu
14.Memantine jconsiderations: j•Cannot jbe jused jwith jamantadine,
jrimantadine, jketamine, jor jdextromethorphan
• Used jas ja jmonotherapy jor jin jconjunction jwith jChEIs, jif jso,
2 j/
j19
, Patient jis jat jincreased jrisk jof jfalls- jfall jprecautions jare jrequired, jand
jdriving jis jnot jallowed jd/t jdelayed jreactions
15.Aducanumab j- janti jamyloid: jclinical jtrial, jacts jby jbinding jto jand
jreducing jamyloid-beta jplaque jin jthe jbrain.
16.Grandma jDoesn't jRemember jMEMAN: jGalantamine, jDonepezil,
jRivastig- jmine, jMemantine
17.Patients jwho jtake jmeds jcan jreverse jAD: jFalse j- jAD jcannot jbe
jreversed. jMedication jis jused jto jalleviate jsymptoms jand jdelay
jprogression
18.clozapine jis ja jfirst jline jtx jfor jbehavioral jsymptoms jin jAD: jfalse j- jthese
jare jnot jused jfirst jline jbecause jthey jincrease jthe jrisk jof jmortality jand
jcardiovascular jSE. jSSRIs jand jSNRIs jare jused jfirst jline
19.Galantamine j- jcholinesterase jinhibitors jpregnancy: jcholinesterase
jin- jhibitors jare jnot jrecommended jfor jpregnancy jor jbreastfeeding
20.A jpatient jis jprescribed jmemantine jin jcombination jwith jdonepezil. jWhich
jof jthe jfollowing jteachings jneeds jto jbe jincluded jin jthe jpatient's jcare jplan?:
jThe jpatient jneeds jto jensure jtheir jliving jenvironment jis jfree jof jclutter
jand jwell jlit. jDriving jis javoided jfor jthe jduration jthe jpatient jis jon jthe
jmedication
21.•Which jof jthe jfollowing jstatements jis jtrue jabout jgalantamine?: jThis
jmed- jication jshould jbe javoided jin jpatients jwho jfrequently juse jNSAIDS
22.DSM j5 jCriteria jfor jMemory jLoss: j•Memory jloss- jdifficulty jin jlaying
jdown jnew jmemories jand/or jin jthe jrecall jof jprevious jmemories
• May jincludes jdeficits jin:
• Registration- jability jto jrepeat jnumbers jor jwords jimmediately jafter
jhearing jthem
• Short-term j recall
• Recognition- jthe jability jto jretrieve jpreciously jforgotten jnames jif
jprovided jwith jclues
• Remote jmemory- jrecall jof jimportant jof jhistorical jevents
23.•Memory jloss jetiologies jinclude:: j•Direct jphysiological jeffect jon
jthe jCNS j(substance juse jor ja jmedication)
• General jmedical jconditions
• Associated jfeature jof janother jmental jdisorder
• A jdissociative jphenomenon j(PTSD, jDissociative jDisorder)
24.DSM j5 jcriteria: j•It jmust jbe jdetermined jthat jthe jmemory jloss jis
jsufficiently jsevere jto jbe jclinically jsignificant jand jthat jit jis jmore jsevere
jthan jmight jbe jexpected jgiven jthe jperson's jprevious jmemory
jfunctioning jand jthe jnorms jfor jhis jor jher jage
3 j/
j19
1.Genetics jAD: jGenes jplay ja jstrong jrole- jheritability jof j58-79% jfor jlate
jonset jand jover j90% jfor jearly jonset
2.WHAT jARE jTHE jTWO jHALLMARKS jOF jAD?: jamyloid jplaques jand
jneurofibril- jlary jtangles j-•Responsible jfor jissues jwith jmemory jand
jhigher-level jthinking
3.Neural jnetworks jAD: jDamage jto jsynapses, jmitochondrial
jabnormalities, jand jinflammatory jprocesses jcause jNTM jfailure jand
jneuronal jdeath
4.NTM jresponsible jfor jmemory jand jlearning: jACh
5.Does jAD jlead jto jan jincrease jor jdecrease jin jthis jNTM jactivity: jLeads jto
ja jdecrease jin jNTM jactivity
6.Decreased jACh jleads jto: ja jpermanent jloss jof jcholinergic jneurons= jthis
jcauses jshort jterm jmemory jdysfunction
7.Cholinesterase jinhibitors jexamples:
jDonepezil jRivastigmine
Galantamine
8.Cholinesterase jinhibitors: jalleviate jsymptoms, jdo jnot jstop
jprogression jIncrease jlevels jof jACH
Improves jcognition jwhich jimproves jmemory jand jthinking
9.Donepezil j(Aricept): jinhibits jcentrally jactive jACH• jHigher jdoses jcause
jhigher jincidence jof jadverse jeffects
10.Cholinesterase jinhibitors j- jWhat jhappens jwhen jadded jto jCYP2D6 jor j3A4?
1 j/
j19
,: jpossibility jof jperipheral jside jeffects
11.•Rivastigmine j(Exelon): jincreases jefficacy jof jboth
jacetylcholinesterase jand jbutyrylcholinesterase
Medications jthat jreduce jor jinhibit jCYP450 jmetabolism jwill jnot jaffect
jrivastigmine jmetabolism
12.Galantamine j(Razadyne, jRazadyne jER): jelevates jACH jin jthe jcerebral
jcortex jto jincrease jAch jrelease jfrom jexisting jpresynaptic jnerve
jterminals. jAlso jincreases jGlu jand j5HT
Cannot jbe jused jconcurrently jwith jNSAIDS jor jmedications jthat jslow jor
jdecrease jHR.
13.Memantine
N-Methyl-D-Aspartate jReceptor jAntagonist: j•NMDA jreceptor jantagonist
• Only japproved jmedication jto jmanage jmoderate- jsevere jAD
• Works jby jpreventing jglutamate jbinding jat jthe jreceptor jsite jand
jregulates jhow jmuch jcalcium jenters jthe jnerve jcell
• Blocking jNMDA jreceptors jprotects jneurons jfrom jthe jeffects jof jtoo
jmuch jGlu
14.Memantine jconsiderations: j•Cannot jbe jused jwith jamantadine,
jrimantadine, jketamine, jor jdextromethorphan
• Used jas ja jmonotherapy jor jin jconjunction jwith jChEIs, jif jso,
2 j/
j19
, Patient jis jat jincreased jrisk jof jfalls- jfall jprecautions jare jrequired, jand
jdriving jis jnot jallowed jd/t jdelayed jreactions
15.Aducanumab j- janti jamyloid: jclinical jtrial, jacts jby jbinding jto jand
jreducing jamyloid-beta jplaque jin jthe jbrain.
16.Grandma jDoesn't jRemember jMEMAN: jGalantamine, jDonepezil,
jRivastig- jmine, jMemantine
17.Patients jwho jtake jmeds jcan jreverse jAD: jFalse j- jAD jcannot jbe
jreversed. jMedication jis jused jto jalleviate jsymptoms jand jdelay
jprogression
18.clozapine jis ja jfirst jline jtx jfor jbehavioral jsymptoms jin jAD: jfalse j- jthese
jare jnot jused jfirst jline jbecause jthey jincrease jthe jrisk jof jmortality jand
jcardiovascular jSE. jSSRIs jand jSNRIs jare jused jfirst jline
19.Galantamine j- jcholinesterase jinhibitors jpregnancy: jcholinesterase
jin- jhibitors jare jnot jrecommended jfor jpregnancy jor jbreastfeeding
20.A jpatient jis jprescribed jmemantine jin jcombination jwith jdonepezil. jWhich
jof jthe jfollowing jteachings jneeds jto jbe jincluded jin jthe jpatient's jcare jplan?:
jThe jpatient jneeds jto jensure jtheir jliving jenvironment jis jfree jof jclutter
jand jwell jlit. jDriving jis javoided jfor jthe jduration jthe jpatient jis jon jthe
jmedication
21.•Which jof jthe jfollowing jstatements jis jtrue jabout jgalantamine?: jThis
jmed- jication jshould jbe javoided jin jpatients jwho jfrequently juse jNSAIDS
22.DSM j5 jCriteria jfor jMemory jLoss: j•Memory jloss- jdifficulty jin jlaying
jdown jnew jmemories jand/or jin jthe jrecall jof jprevious jmemories
• May jincludes jdeficits jin:
• Registration- jability jto jrepeat jnumbers jor jwords jimmediately jafter
jhearing jthem
• Short-term j recall
• Recognition- jthe jability jto jretrieve jpreciously jforgotten jnames jif
jprovided jwith jclues
• Remote jmemory- jrecall jof jimportant jof jhistorical jevents
23.•Memory jloss jetiologies jinclude:: j•Direct jphysiological jeffect jon
jthe jCNS j(substance juse jor ja jmedication)
• General jmedical jconditions
• Associated jfeature jof janother jmental jdisorder
• A jdissociative jphenomenon j(PTSD, jDissociative jDisorder)
24.DSM j5 jcriteria: j•It jmust jbe jdetermined jthat jthe jmemory jloss jis
jsufficiently jsevere jto jbe jclinically jsignificant jand jthat jit jis jmore jsevere
jthan jmight jbe jexpected jgiven jthe jperson's jprevious jmemory
jfunctioning jand jthe jnorms jfor jhis jor jher jage
3 j/
j19
