answers
62-year-old patient with type 2 diabetes has noticed a 30-pound weight
gain over the past 2 years. Which of the following drugs would most
likely worsen her weight gain?
Pramlintide
Exenatide
Rosiglitazone
Saxagliptin Ans✓✓✓ C - Rosiglitazone is correct. Thiazolidinediones
(pioglitazone and rosiglitazone) activate PPAR-gamma receptors in the
body. Activation of these receptors results in mobilization of visceral fat
and promotes deposition in subcutaneous adipose tissue. Pramlintide
and exenatide (Answers A and B) tend to promote weight loss, while
saxagliptin (Answer D) is weight neutral.
A 28-year-old woman with Type 1 diabetes for 10 years needs to re-
calculate a correction bolus based on her new insulin regimen. Her
current total daily dose (TDD) of insulin is 60 units. Which of the
following best estimates the amount 1 unit of insulin will lower her
blood glucose level?
3 mg/dL
8 mg/dL
25 mg/dL
30 mg/dL Ans✓✓✓ D - 30 mg/dL is correct. The Rule of 1800 (some
providers recommend 1700 for patients on insulin pumps, or 1500 for
, patients injecting regular insulin) estimates the amount 1 unit of insulin
will lower her blood glucose level. This patient takes a total daily dose
(TDD) of 60 units (1800 divided by 60 units = 30 mg/dL). A general rule
of thumb is that 1 unit of insulin will lower the blood glucose by 50
mg/dL.
A 28-year-old woman with Type 1 diabetes for 10 years presents for
follow-up. Recent laboratory tests showed fasting plasma glucose of
194 mg/dl and a hemoglobin A1C of 10.3%. A spot urine was positive
for microalbumin at 58. Blood pressure today is 118/64 without
symptoms and all other laboratory values were within normal limits.
Which of the following is the most appropriate blood pressure goal for
this patient based on the 2016 ADA Standards of Care?
< 140/90 mmHg
< 140/80 mmHg
< 130/80 mmHg
< 120/75 mmHg Ans✓✓✓ C - <130/80 mmHg is correct. The 2016 ADA
guidelines recommend a blood pressure goal of <140/90 mmHg for
most adults with diabetes. However, lower blood pressure targets are
considered appropriate for younger patients whose potential duration
of disease is longer; those with albuminuria suggesting presence of
sustained kidney damage; and those in whom the burden of treatment
is minimal. This young patient with type 1 diabetes would certainly be
able to withstand the treatment burden and will likely reap benefits
during her lifetime from tighter blood pressure control.