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• 2025 NURS 6230 Advanced Pathophysiology Midterm Review Guide

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• 2025 NURS 6230 Advanced Pathophysiology Midterm Review Guide

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1. A patient with cirrhosis has developed ascites. Which of the
following is a likely cause of ascites in this patient?
A. Decreased albumin production
B. Increased clotting factors
C. Increased renin production
D. Decreased red blood cell production
Answer: A) Decreased albumin production
Rationale: In cirrhosis, the liver's ability to produce albumin is
impaired, leading to a decrease in plasma oncotic pressure, which
contributes to fluid accumulation in the abdomen (ascites).

2. What is the most common cause of peptic ulcers?
A. Stress
B. Use of nonsteroidal anti-inflammatory drugs (NSAIDs)
C. Helicobacter pylori infection
D. Excessive alcohol consumption
Answer: C) Helicobacter pylori infection
Rationale: H. pylori infection is the leading cause of peptic ulcers
due to its ability to disrupt the mucosal lining of the stomach.

3. Which of the following is a primary complication of untreated
hypertension?
A. Diabetes
B. Stroke
C. Asthma
D. Hyperthyroidism
Answer: B) Stroke
Rationale: Untreated hypertension can cause damage to blood
vessels, increasing the risk of a stroke due to the development of
atherosclerosis or rupture of a weakened vessel.

,4. What is the primary cause of hypercapnia in patients with
chronic obstructive pulmonary disease (COPD)?
A. Increased carbon dioxide production
B. Airway obstruction
C. Pulmonary fibrosis
D. Decreased tidal volume
Answer: B) Airway obstruction
Rationale: In COPD, airway obstruction leads to difficulty in
exhaling CO2, resulting in the accumulation of carbon dioxide in
the bloodstream (hypercapnia).

5. What is a common sign of a urinary tract infection (UTI) in
older adults?
A. Fever and chills
B. Confusion and delirium
C. Painful urination
D. Excessive thirst
Answer: B) Confusion and delirium
Rationale: In older adults, UTIs may present with atypical
symptoms such as confusion, delirium, or agitation, rather than
the typical symptoms of fever and dysuria.

6. Which of the following lab findings is typically seen in a patient
with acute renal failure (ARF)?
A. Increased serum creatinine
B. Decreased serum potassium
C. Decreased blood urea nitrogen (BUN)
D. Decreased urine output (oliguria)
Answer: A) Increased serum creatinine
Rationale: In acute renal failure, the kidneys' ability to excrete
waste products diminishes, leading to an increase in serum
creatinine levels.

, 7. What is the primary cause of osteoarthritis?
A. Autoimmune reaction
B. Wear and tear on the joints
C. Bacterial infection
D. Vitamin D deficiency
Answer: B) Wear and tear on the joints
Rationale: Osteoarthritis is primarily caused by the degeneration
of cartilage due to repetitive use or aging, leading to joint pain
and stiffness.

8. Which of the following is a common sign of hypovolemic
shock?
A. Bradycardia
B. Tachycardia
C. Warm skin
D. Hypertension
Answer: B) Tachycardia
Rationale: In hypovolemic shock, blood volume decreases, and the
body compensates by increasing the heart rate (tachycardia) to
maintain blood flow to vital organs.

9. What is a classic symptom of Parkinson’s disease?
A. Muscle rigidity
B. Hypotension
C. Polyuria
D. Weight gain
Answer: A) Muscle rigidity
Rationale: Parkinson’s disease is characterized by symptoms such
as muscle rigidity, tremors, and bradykinesia due to a loss of
dopaminergic neurons in the brain.

10. A patient with diabetes mellitus presents with polyuria,
polydipsia, and weight loss. What condition might these

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