PHARM EXAM 1 EXAM
QUESTIONS WITH
CORRECT VERIFIED
SOLUTIONS RATED A+
"Which of the following statements about the major distribution barriers (blood-brain or fetal-
placental) is true?
A. Water soluble and ionized drugs cross these barriers rapidly.
B. The blood-brain barrier slows the entry of many drugs into and from brain cells.
C. The fetal-placental barrier protects the fetus from drugs taken by the mother.
D. Lipid soluble drugs do not pass these barriers and are safe for pregnant women. - CORRECT
ANSWER=> B"
"Drugs are metabolized mainly by the liver via Phase I or Phase II reactions. The purpose of both
of these types of reactions is to:
A. Inactivate prodrugs before they can be activated by target tissues
B. Change the drugs so they can cross plasma membranes
C. Change drug molecules to a form that an excretory organ can excrete
D. Make these drugs more ionized and polar to facilitate excretion - CORRECT ANSWER=> C"
"Once they have been metabolized by the liver, the metabolites may be:
A. More active than the parent drug
B. Less active than the parent drug
C. Totally "deactivated" so that they are excreted without any effect
D. All of the above - CORRECT ANSWER=> D"
"All drugs continue to act in the body until they are changed or excreted. The ability of the body
to excrete drugs via the renal system would be increased by:
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,A. Reduced circulation and perfusion of the kidney
B. Chronic renal disease
C. Competition for a transport site by another drug
D. Unbinding a nonvolatile drug from plasma proteins - CORRECT ANSWER=> D"
"Steady state is:
A. The point on the drug concentration curve when absorption exceeds excretion
B. When the amount of drug in the body remains constant
C. When the amount of drug in the body stays below the MTC
D. All of the above - CORRECT ANSWER=> B"
"Two different pain meds are given together for pain relief. The drug-drug interaction is:
A. Synergistic
B. Antagonistic
C. Potentiative
D. Additive - CORRECT ANSWER=> D"
"Actions taken to reduce drug-drug interaction problems include all of the following EXCEPT:
A. Reducing the dose of one of the drugs
B. Scheduling their administration at different times
C. Prescribing a third drug to counteract the adverse reaction of the combination
D. Reducing the dosage of both drugs - CORRECT ANSWER=> C"
"Phase I oxidative-reductive processes of drug metabolism require certain nutritional elements.
Which of the following would reduce or inhibit this process?
A. Protein malnutrition
B.Iron deficiency anemia
C.Both A and B
D.Neither A nor B - CORRECT ANSWER=> D"
"The time required for the amount of drug in the body to decrease by 50% is called:
A.Steady state
B.Half-life
C.Phase II metabolism
D.Reduced bioavailability time - CORRECT ANSWER=> B"
"An agonist activates a receptor and stimulates a response. When given frequently over time
the body may:
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, A.Up-regulate the total number of receptors
B.Block the receptor with a partial agonist
C.Alter the drug's metabolism
D.Down-regulate the numbers of that specific receptor - CORRECT ANSWER=> D"
"Drug antagonism is best defined as an effect of a drug that:
A.Leads to major physiologic psychological dependence
B.Is modified by the concurrent administration of another drug
C.Cannot be metabolized before another dose is administered
D.Leads to a decreased physiologic response when combined with another drug - CORRECT
ANSWER=> B"
"Instructions to a client regarding self-administration of oral enteric-coated tablets should
include which of the following statements?
A."Avoid any other oral medicines while taking this drug."
B."If swallowing this tablet is difficult, dissolve it in 3 ounces of orange juice."
C."The tablet may be crushed if you have any difficultly taking it."
D."To achieve best effect, take the tablet with at least 8 ounces of fluid." - CORRECT ANSWER=>
D"
"The major reason for not crushing a sustained release capsule is that, if crushed, the coated
beads of the drugs could possibly result in:
A.Disintegration
B.Toxicity
C.Malabsorption
D.Deterioration - CORRECT ANSWER=> B"
"Which of the following substances is the most likely to be absorbed in the intestines rather
than in the stomach?
A.Sodium bicarbonate
B.Ascorbic acid
C.Salicylic acid
D.Glucose - CORRECT ANSWER=> A"
"Which of the following variables is a factor in drug absorption?
A.The smaller the surface area for absorption, the more rapidly the drug is absorbed.
B.A rich blood supply to the area of absorption leads to better absorption.
C.The less soluble the drug, the more easily it is absorbed.
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QUESTIONS WITH
CORRECT VERIFIED
SOLUTIONS RATED A+
"Which of the following statements about the major distribution barriers (blood-brain or fetal-
placental) is true?
A. Water soluble and ionized drugs cross these barriers rapidly.
B. The blood-brain barrier slows the entry of many drugs into and from brain cells.
C. The fetal-placental barrier protects the fetus from drugs taken by the mother.
D. Lipid soluble drugs do not pass these barriers and are safe for pregnant women. - CORRECT
ANSWER=> B"
"Drugs are metabolized mainly by the liver via Phase I or Phase II reactions. The purpose of both
of these types of reactions is to:
A. Inactivate prodrugs before they can be activated by target tissues
B. Change the drugs so they can cross plasma membranes
C. Change drug molecules to a form that an excretory organ can excrete
D. Make these drugs more ionized and polar to facilitate excretion - CORRECT ANSWER=> C"
"Once they have been metabolized by the liver, the metabolites may be:
A. More active than the parent drug
B. Less active than the parent drug
C. Totally "deactivated" so that they are excreted without any effect
D. All of the above - CORRECT ANSWER=> D"
"All drugs continue to act in the body until they are changed or excreted. The ability of the body
to excrete drugs via the renal system would be increased by:
Page | 1
,A. Reduced circulation and perfusion of the kidney
B. Chronic renal disease
C. Competition for a transport site by another drug
D. Unbinding a nonvolatile drug from plasma proteins - CORRECT ANSWER=> D"
"Steady state is:
A. The point on the drug concentration curve when absorption exceeds excretion
B. When the amount of drug in the body remains constant
C. When the amount of drug in the body stays below the MTC
D. All of the above - CORRECT ANSWER=> B"
"Two different pain meds are given together for pain relief. The drug-drug interaction is:
A. Synergistic
B. Antagonistic
C. Potentiative
D. Additive - CORRECT ANSWER=> D"
"Actions taken to reduce drug-drug interaction problems include all of the following EXCEPT:
A. Reducing the dose of one of the drugs
B. Scheduling their administration at different times
C. Prescribing a third drug to counteract the adverse reaction of the combination
D. Reducing the dosage of both drugs - CORRECT ANSWER=> C"
"Phase I oxidative-reductive processes of drug metabolism require certain nutritional elements.
Which of the following would reduce or inhibit this process?
A. Protein malnutrition
B.Iron deficiency anemia
C.Both A and B
D.Neither A nor B - CORRECT ANSWER=> D"
"The time required for the amount of drug in the body to decrease by 50% is called:
A.Steady state
B.Half-life
C.Phase II metabolism
D.Reduced bioavailability time - CORRECT ANSWER=> B"
"An agonist activates a receptor and stimulates a response. When given frequently over time
the body may:
Page | 2
, A.Up-regulate the total number of receptors
B.Block the receptor with a partial agonist
C.Alter the drug's metabolism
D.Down-regulate the numbers of that specific receptor - CORRECT ANSWER=> D"
"Drug antagonism is best defined as an effect of a drug that:
A.Leads to major physiologic psychological dependence
B.Is modified by the concurrent administration of another drug
C.Cannot be metabolized before another dose is administered
D.Leads to a decreased physiologic response when combined with another drug - CORRECT
ANSWER=> B"
"Instructions to a client regarding self-administration of oral enteric-coated tablets should
include which of the following statements?
A."Avoid any other oral medicines while taking this drug."
B."If swallowing this tablet is difficult, dissolve it in 3 ounces of orange juice."
C."The tablet may be crushed if you have any difficultly taking it."
D."To achieve best effect, take the tablet with at least 8 ounces of fluid." - CORRECT ANSWER=>
D"
"The major reason for not crushing a sustained release capsule is that, if crushed, the coated
beads of the drugs could possibly result in:
A.Disintegration
B.Toxicity
C.Malabsorption
D.Deterioration - CORRECT ANSWER=> B"
"Which of the following substances is the most likely to be absorbed in the intestines rather
than in the stomach?
A.Sodium bicarbonate
B.Ascorbic acid
C.Salicylic acid
D.Glucose - CORRECT ANSWER=> A"
"Which of the following variables is a factor in drug absorption?
A.The smaller the surface area for absorption, the more rapidly the drug is absorbed.
B.A rich blood supply to the area of absorption leads to better absorption.
C.The less soluble the drug, the more easily it is absorbed.
Page | 3
