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Ultimate HESI Pharmacology Review 2025: 50 MCQs with Detailed Rationales

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Ultimate HESI Pharmacology Review 2025: 50 MCQs with Detailed Rationales Description This comprehensive 50‑question HESI Pharmacology review is tailored for nursing students gearing up for the 2025 exam, featuring detailed rationales that explain mechanisms, therapeutic uses, adverse effects, and key nursing considerations . It covers all major pharmacology domains—from autonomic agents and cardiovascular drugs to anti‑infectives, endocrine therapies, and pain management—ensuring you master high‑yield content efficiently Studocu . Perfect for HESI and NCLEX prep, this set integrates current best practices and up‑to‑date exam strategies to boost your confidence and performance Quizlet . Hashtags #HESI2025 Best Hashtags #PharmacologyReview Best Hashtags #NursingExamPrep Best Hashtags #HESIPharmacology Best Hashtags #NurseStudentLife Best Hashtags

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Section I: Autonomic Agents
1. A client is experiencing symptomatic bradycardia.
Which medication should the nurse prepare?
A. Atropine
B. Propranolol
C. Metoprolol
D. Bethanechol
Answer: A. Atropine
Rationale: Atropine blocks muscarinic receptors,
inhibiting parasympathetic stimulation of the heart and
increasing heart rate (NursingTip).
2. A patient with asthma is prescribed albuterol.
Which statement indicates understanding?
A. “I will use it before exercise.”
B. “It will decrease mucus production.”
C. “It blocks beta-1 receptors.”
D. “I should take it with meals.”
Answer: A. “I will use it before exercise.”
Rationale: Albuterol is a β₂-agonist that
bronchodilates and is often used prophylactically
before exertion (Studocu).
3. Which drug would be contraindicated in a client
taking a nonselective β-blocker?
A. Atenolol
B. Metoprolol
C. Propranolol
D. Albuterol

, Answer: D. Albuterol
Rationale: Propranolol blocks both β₁ and β₂
receptors; using albuterol (a β₂-agonist) can be
antagonized and exacerbate bronchospasm
(Studocu).
4. For urinary retention following surgery, the nurse
anticipates administering:
A. Bethanechol
B. Neostigmine
C. Atropine
D. Oxybutynin
Answer: A. Bethanechol
Rationale: Bethanechol is a muscarinic agonist that
stimulates bladder contraction (NursingTip).
5. A patient on atropine should be monitored for
which adverse effect?
A. Diaphoresis
B. Urinary retention
C. Bradycardia
D. Diarrhea
Answer: B. Urinary retention
Rationale: Antimuscarinic effects include decreased
bladder tone leading to retention (NursingTip).
Section II: Cardiovascular Drugs
6. Which medication is first-line for acute angina
relief?
A. Metoprolol

, B. Nitroglycerin sublingual
C. Diltiazem
D. Lisinopril
Answer: B. Nitroglycerin sublingual
Rationale: Rapidly reduces preload via venous
dilation to relieve chest pain (Naxlex).
7. A client on furosemide should be monitored for:
A. Hyperkalemia
B. Hypokalemia
C. Hypertension
D. Bradycardia
Answer: B. Hypokalemia
Rationale: Loop diuretics increase K⁺ excretion,
risking hypokalemia (Naxlex).
8. Which antihypertensive drug is contraindicated in
pregnancy?
A. Methyldopa
B. Labetalol
C. Enalapril
D. Hydralazine
Answer: C. Enalapril
Rationale: ACE inhibitors cause fetal renal damage
and are contraindicated (Naxlex).
9. For dysrhythmias, amiodarone’s primary action is
to:
A. Block calcium channels
B. Prolong repolarization

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