Test bank for Tietz Fundamentals of Clinical Chemistry
and Molecular Diagnostics,
8th Edition by Nader Rifai, PhD
Chapters 1 - 49
,Tietz ghFundamentals ghof ghClinical ghChemistry ghand ghMolecular ghDiagnostics gh8th g h Edition ghTest ghBank
Table ghof ghcontents:
I. ghPrinciples ghOf ghLaboratory ghMedicine
Chapter gh1. ghClinical ghChemistry, ghMolecular ghDiagnostics, ghand ghLaboratory ghMedicine
Chapter gh2. ghSelection ghand ghAnalytical ghEvaluation ghof ghMethods gh— ghWith ghStatistical
ghTechniques
Chapter gh3. ghClinical ghEvaluation ghof ghMethods
Chapter gh4. ghEvidence-Based ghLaboratory ghMedicine
Chapter gh5. ghEstablishment ghand ghUse ghof ghReference ghValues
Chapter gh6. ghSpecimen ghCollection, ghProcessing, ghand ghOther ghPreanalytical ghVariables
Chapter gh7. ghQuality ghManagement
II. ghAnalytical ghTechniques ghAnd ghInstrumentation
Chapter gh8. ghPrinciples ghof ghBasic ghTechniques ghand ghLaboratory ghSafety
Chapter gh9. ghOptical ghTechniques
Chapter gh10. ghElectrochemistry ghand ghChemical ghSensors
Chapter gh11. ghElectrophoresis
Chapter gh12. ghChromatography
Chapter gh13. ghMass ghSpectrometry
Chapter gh14. ghEnzyme ghand ghRate ghAnalyses
Chapter gh15. ghImmunochemical ghTechniques
Chapter gh16 ghAutomation
Chapter gh17. ghPoint-of-Care ghInstrumentation
III. g h Analytes
Chapter gh18. ghAmino ghAcids, ghPeptides, ghand ghProteins
Chapter gh19. ghSerum ghEnzymes
Chapter gh20. ghTumor ghMarkers ghand ghCancer ghGenes
Chapter gh21. ghKidney ghFunction ghTests gh— ghCreatinine, ghGFR, ghUrea, ghand ghUric ghAcid
Chapter gh22. ghCarbohydrates
Chapter gh23. ghLipids, ghLipoproteins, ghApolipoproteins, ghand ghOther ghCardiac ghRisk ghFactors
Chapter gh24. ghElectrolytes ghand ghBlood ghGases
Chapter gh25. ghHormones
Chapter gh26. g h Catecholamines ghand ghSerotonin
Chapter gh27. g h Vitamins, ghTrace ghElements, ghNutritional ghAssessment
Chapter gh28. ghHemoglobin, ghIron, ghand ghBilirubin
Chapter gh29. ghPorphyrins ghand ghPorphyrias
Chapter gh30. ghTherapeutic ghDrugs ghand ghTheir ghManagement
Chapter gh31. ghClinical ghToxicology
Chapter gh32. g h Toxic ghMetals
IV. g h Pathophysiology
Chapter gh33. ghDiabetes
,Chapter gh34. g h Cardiovascular ghDisease
Chapter gh35. ghKidney ghDisease
Chapter gh36. g h Physiology ghand ghDisorders ghof ghWater, ghElectrolyte, ghand ghAcid-Base
ghMetabolism
Chapter gh37. gh ghLiver ghDisease
Chapter gh38. g h Gastrointestinal ghand ghPancreatic ghDiseases
Chapter gh39. gh ghDisorders ghof ghBone ghand ghMineral ghMetabolism
Chapter gh40. gh ghDisorders ghof ghthe ghPituitary ghGland
Chapter gh41. g h Disorders ghof ghthe ghAdrenal ghCortex
Chapter gh42. g h Thyroid ghDisorders
Chapter gh43. g h Reproduction-Related ghDisorders
Chapter gh44. gh ghPregnancy ghand ghPrenatal ghTesting
Chapter gh45. g h Newborn ghScreening ghand ghInborn ghErrors ghof ghMetabolism
Chapter gh46. ghPharmacogenetics
V. g h Molecular ghDiagnostics
Chapter gh47. ghPrinciples ghof ghMolecular ghBiology
Chapter gh48. ghNucleic ghAcid ghTechniques ghand ghApplications
Chapter gh49. ghGenomes ghand ghNucleic ghAcid ghAlterations
, Chapter gh01: ghClinical ghChemistry, ghMolecular ghDiagnostics, ghand ghLaboratory
ghMedicine ghTestghBank
MULTIPLE ghCHOICE
1. An ghindividual ghworking ghin gha ghclinical ghchemistry ghlaboratory ghis ghmarried ghto gha
ghsales ghrepresentative ghwho ghworks ghfor gha ghcompany ghthat ghsells ghchemistry
ghlaboratory ghsupplies. ghWhen ghthe ghlaboratory ghmanager ghrequests gha ghlist ghof
ghneeded ghsupplies, ghcost ghof ghsupplies, ghand ghvendors, ghthis ghindividual ghonly
ghrecommends ghthe ghspouse’s ghcompany ghas ghthe ghvendor. ghThis ghis ghconsidered ghto ghbe
gha(n):
a. accounting ghissue.
b. possible ghconflict ghof ghinterest.
c. maintenance ghof ghconfidentiality ghissue.
d. problem ghwith ghresource ghallocation.
ANS: g h B
Concern ghhas ghbeen ghraised ghover ghthe ghinterrelationships ghbetween ghpractitioners ghin
ghthe ghmedical ghfieldghand ghcommercial ghsuppliers ghof ghdrugs, ghdevices, ghequipment,
ghetc., ghto ghthe ghmedical ghprofession.
Similarly, ghrelationships ghhave ghbeen ghscrutinized ghbetween ghclinical ghlaboratorians ghand
ghmanufacturers ghand ghproviders ghof ghdiagnostic ghequipment ghand ghsupplies. ghThese
ghconcerns ghled ghthe ghNational ghInstitutes ghof ghHealth gh(NIH) ghin gh1995 ghto ghrequire
ghofficial ghinstitutional ghreview ghof ghfinancial ghdisclosure ghby ghresearchers ghand
ghmanagement ghof ghsituations ghin ghwhich ghdisclosure ghindicates ghpotentialghconflicts ghof
ghinterest.
DIF: 1 REF: gh gh ghPage gh4-5 OBJ: g h 6 gh| gh7
2. A ghpatient ghvisits ghher ghphysician ghstating ghthat ghher ghprescribed ghpainkiller ghis ghnot
ghworking ghto ghreduce ghthe ghpain ghfollowing ghher ghrecent ghsurgery. ghA ghfriend ghof ghthe
ghpatient ghclaims ghthat ghthe ghsame ghpainkillergh“worked ghwonders” ghto ghreduce ghher
ghpain ghafter ghthe ghsame ghsurgery. ghThe ghphysician ghstates ghthat ghthe ghdifference ghin
ghthe gheffect ghof ghthe ghdrug ghmight ghbe ghcaused ghby , ghwhich ghis ghstudied ghin
ghpharmacogenetics.
a. epidemiology
b. an ghinherited ghdisease
c. a ghconflict ghof ghinterest
d. a ghgenetic ghvariation ghin ghdrug-metabolizing ghenzymes
ANS: g h D
Pharmacogenetics ghis ghthe ghstudy ghof ghthe ghgenetic ghvariation ghof ghdrug
ghmetabolism ghbetweenghindividuals.
DIF: 1 REF: gh gh ghPage gh3 OBJ: g h 1
3. John ghworks ghin gha ghmolecular ghdiagnostics ghlaboratory ghand ghreceives gha ghblood
ghsample ghthat ghhas ghthe ghname ghof gha ghclose ghfriend ghprinted ghon ghthe ghbar-coded
ghlabel. ghThe ghgenetic ghtest ghthat ghis ghordered ghon ghtheghfriend’s ghsample ghwould
ghprovide ghdiagnostic ghinformation ghabout gha ghdisorder ghthat ghhas gha ghpoor
ghprognosis, ghand ghthe ghtest ghis ghusually ghperformed ghby ghJohn. ghHe ghasks gha ghfellow
ghemployee ghto ghanalyzeghthe ghsample ghfor ghhim ghand ghnot ghdivulge ghthe ghresults. ghThis
and Molecular Diagnostics,
8th Edition by Nader Rifai, PhD
Chapters 1 - 49
,Tietz ghFundamentals ghof ghClinical ghChemistry ghand ghMolecular ghDiagnostics gh8th g h Edition ghTest ghBank
Table ghof ghcontents:
I. ghPrinciples ghOf ghLaboratory ghMedicine
Chapter gh1. ghClinical ghChemistry, ghMolecular ghDiagnostics, ghand ghLaboratory ghMedicine
Chapter gh2. ghSelection ghand ghAnalytical ghEvaluation ghof ghMethods gh— ghWith ghStatistical
ghTechniques
Chapter gh3. ghClinical ghEvaluation ghof ghMethods
Chapter gh4. ghEvidence-Based ghLaboratory ghMedicine
Chapter gh5. ghEstablishment ghand ghUse ghof ghReference ghValues
Chapter gh6. ghSpecimen ghCollection, ghProcessing, ghand ghOther ghPreanalytical ghVariables
Chapter gh7. ghQuality ghManagement
II. ghAnalytical ghTechniques ghAnd ghInstrumentation
Chapter gh8. ghPrinciples ghof ghBasic ghTechniques ghand ghLaboratory ghSafety
Chapter gh9. ghOptical ghTechniques
Chapter gh10. ghElectrochemistry ghand ghChemical ghSensors
Chapter gh11. ghElectrophoresis
Chapter gh12. ghChromatography
Chapter gh13. ghMass ghSpectrometry
Chapter gh14. ghEnzyme ghand ghRate ghAnalyses
Chapter gh15. ghImmunochemical ghTechniques
Chapter gh16 ghAutomation
Chapter gh17. ghPoint-of-Care ghInstrumentation
III. g h Analytes
Chapter gh18. ghAmino ghAcids, ghPeptides, ghand ghProteins
Chapter gh19. ghSerum ghEnzymes
Chapter gh20. ghTumor ghMarkers ghand ghCancer ghGenes
Chapter gh21. ghKidney ghFunction ghTests gh— ghCreatinine, ghGFR, ghUrea, ghand ghUric ghAcid
Chapter gh22. ghCarbohydrates
Chapter gh23. ghLipids, ghLipoproteins, ghApolipoproteins, ghand ghOther ghCardiac ghRisk ghFactors
Chapter gh24. ghElectrolytes ghand ghBlood ghGases
Chapter gh25. ghHormones
Chapter gh26. g h Catecholamines ghand ghSerotonin
Chapter gh27. g h Vitamins, ghTrace ghElements, ghNutritional ghAssessment
Chapter gh28. ghHemoglobin, ghIron, ghand ghBilirubin
Chapter gh29. ghPorphyrins ghand ghPorphyrias
Chapter gh30. ghTherapeutic ghDrugs ghand ghTheir ghManagement
Chapter gh31. ghClinical ghToxicology
Chapter gh32. g h Toxic ghMetals
IV. g h Pathophysiology
Chapter gh33. ghDiabetes
,Chapter gh34. g h Cardiovascular ghDisease
Chapter gh35. ghKidney ghDisease
Chapter gh36. g h Physiology ghand ghDisorders ghof ghWater, ghElectrolyte, ghand ghAcid-Base
ghMetabolism
Chapter gh37. gh ghLiver ghDisease
Chapter gh38. g h Gastrointestinal ghand ghPancreatic ghDiseases
Chapter gh39. gh ghDisorders ghof ghBone ghand ghMineral ghMetabolism
Chapter gh40. gh ghDisorders ghof ghthe ghPituitary ghGland
Chapter gh41. g h Disorders ghof ghthe ghAdrenal ghCortex
Chapter gh42. g h Thyroid ghDisorders
Chapter gh43. g h Reproduction-Related ghDisorders
Chapter gh44. gh ghPregnancy ghand ghPrenatal ghTesting
Chapter gh45. g h Newborn ghScreening ghand ghInborn ghErrors ghof ghMetabolism
Chapter gh46. ghPharmacogenetics
V. g h Molecular ghDiagnostics
Chapter gh47. ghPrinciples ghof ghMolecular ghBiology
Chapter gh48. ghNucleic ghAcid ghTechniques ghand ghApplications
Chapter gh49. ghGenomes ghand ghNucleic ghAcid ghAlterations
, Chapter gh01: ghClinical ghChemistry, ghMolecular ghDiagnostics, ghand ghLaboratory
ghMedicine ghTestghBank
MULTIPLE ghCHOICE
1. An ghindividual ghworking ghin gha ghclinical ghchemistry ghlaboratory ghis ghmarried ghto gha
ghsales ghrepresentative ghwho ghworks ghfor gha ghcompany ghthat ghsells ghchemistry
ghlaboratory ghsupplies. ghWhen ghthe ghlaboratory ghmanager ghrequests gha ghlist ghof
ghneeded ghsupplies, ghcost ghof ghsupplies, ghand ghvendors, ghthis ghindividual ghonly
ghrecommends ghthe ghspouse’s ghcompany ghas ghthe ghvendor. ghThis ghis ghconsidered ghto ghbe
gha(n):
a. accounting ghissue.
b. possible ghconflict ghof ghinterest.
c. maintenance ghof ghconfidentiality ghissue.
d. problem ghwith ghresource ghallocation.
ANS: g h B
Concern ghhas ghbeen ghraised ghover ghthe ghinterrelationships ghbetween ghpractitioners ghin
ghthe ghmedical ghfieldghand ghcommercial ghsuppliers ghof ghdrugs, ghdevices, ghequipment,
ghetc., ghto ghthe ghmedical ghprofession.
Similarly, ghrelationships ghhave ghbeen ghscrutinized ghbetween ghclinical ghlaboratorians ghand
ghmanufacturers ghand ghproviders ghof ghdiagnostic ghequipment ghand ghsupplies. ghThese
ghconcerns ghled ghthe ghNational ghInstitutes ghof ghHealth gh(NIH) ghin gh1995 ghto ghrequire
ghofficial ghinstitutional ghreview ghof ghfinancial ghdisclosure ghby ghresearchers ghand
ghmanagement ghof ghsituations ghin ghwhich ghdisclosure ghindicates ghpotentialghconflicts ghof
ghinterest.
DIF: 1 REF: gh gh ghPage gh4-5 OBJ: g h 6 gh| gh7
2. A ghpatient ghvisits ghher ghphysician ghstating ghthat ghher ghprescribed ghpainkiller ghis ghnot
ghworking ghto ghreduce ghthe ghpain ghfollowing ghher ghrecent ghsurgery. ghA ghfriend ghof ghthe
ghpatient ghclaims ghthat ghthe ghsame ghpainkillergh“worked ghwonders” ghto ghreduce ghher
ghpain ghafter ghthe ghsame ghsurgery. ghThe ghphysician ghstates ghthat ghthe ghdifference ghin
ghthe gheffect ghof ghthe ghdrug ghmight ghbe ghcaused ghby , ghwhich ghis ghstudied ghin
ghpharmacogenetics.
a. epidemiology
b. an ghinherited ghdisease
c. a ghconflict ghof ghinterest
d. a ghgenetic ghvariation ghin ghdrug-metabolizing ghenzymes
ANS: g h D
Pharmacogenetics ghis ghthe ghstudy ghof ghthe ghgenetic ghvariation ghof ghdrug
ghmetabolism ghbetweenghindividuals.
DIF: 1 REF: gh gh ghPage gh3 OBJ: g h 1
3. John ghworks ghin gha ghmolecular ghdiagnostics ghlaboratory ghand ghreceives gha ghblood
ghsample ghthat ghhas ghthe ghname ghof gha ghclose ghfriend ghprinted ghon ghthe ghbar-coded
ghlabel. ghThe ghgenetic ghtest ghthat ghis ghordered ghon ghtheghfriend’s ghsample ghwould
ghprovide ghdiagnostic ghinformation ghabout gha ghdisorder ghthat ghhas gha ghpoor
ghprognosis, ghand ghthe ghtest ghis ghusually ghperformed ghby ghJohn. ghHe ghasks gha ghfellow
ghemployee ghto ghanalyzeghthe ghsample ghfor ghhim ghand ghnot ghdivulge ghthe ghresults. ghThis
