Infertility - Definition - Answers The inability to conceive after 1 year of unprotected intercourse
The probability of achieving pregnancy in 1 cycle is ___ % - Answers 20%
___% of all couples with normal fertility will achieve pregnancy in 12 months - Answers 85%
Female fertility should be examined prior to male. True or False? - Answers False.
Male fertility is non invasive and should be checked first.
General factors causing infertility (4) - Answers - Weight (overweight BMI >29 or very underweight)
- Alcohol use
- Recreational drug use
- Smoking (active and 2nd hand) - male and female
Female causes of infertility (3) - Answers - Increasing age
- Ovulatory dysfunction (PCOS, Anovulation, Luteal phase defect, hyperprolactemia)
- Anatomical factors (tubal dysfunction, cervical factors)
Fertility declines after age ___, marked decline after age ___. - Answers 30
40
With increasing age, why is it harder to conceive? (3) - Answers - Fewer and lower quality eggs remain
- Ovulation becomes more irregular
- Increased exposure to disease development (eg. PID, endometriosis)
Anovulation results from disruption of the hypothalmic-pituitary-ovarian axis. True or False? - Answers
True
Hypothalmic-pituitary-ovarian axis can be thrown off by what causes? (4) - Answers CEASED:
Chemotherapy
Excessive exercise
, Anorexia/bulimia
Stress
Endocrine diseases such as DM, Thyroid dysfunction
Direct injury(neoplasm)
The most common cause of anovulation is PCOS. True or False? - Answers True.
Affects 6-7% of women of reproductive age.
PCOS - Pathophysiology? - Answers Inappropriate gonadotropin secretion - *hypersecretion of LH and
Insulin stimulate production of androgens*.
Insulin sensitivity in ovaries(causing hyperandrogenism). Insulin resistance in other tissues.
PCOS is defined by 3 characteristics: - Answers - Hyperandrogenism
- Oligomenorrhea or amenorrhea
- Polycystic ovaries
PCOS signs and symptoms (4) - Answers - Hyperandrogenism (hirsutism, acne, male pattern baldness,
ancanthosis nigricans)
- Obesity
- Menstrual cycle anomalies
- Infertility
PCOS - 1st line Pharmacotherapy to treat infertility aspect - Answers Clomiphene citrate
Metformin
PCOS - To treat hirsutism, can give ___ - Answers Spironolactone
Metformin
PCOS - To treat abnormal menstruation, can give ___ - Answers OCPs