1 | Page
nanomedicine test 3 Questions and Correct Answers/
Latest Update / Already Graded
difference between nano devices and nanoparticles
Ans: - nano devices: they are made of nanoparticles (usually with different
composition -- ex. microneedles and nano needles, and nano-valves for drug
delivery)
- nanoparticles: particle of any shape with dimensions in the 1 x 10 ^-9 - 1x10 ^-7
(1-100nm)
why did we study micro-needles if they are not a nano object?
Ans: because they are still relevant in the field of medicine. Microneedles permit
transport of macromolecules, as well as possibly supramolecular complexes and
Microparticles
which skin layer can be reached using micro-needles?
Ans: stratum corneum
describe the three transdermal drug delivery methods using micro-needles
Ans: 1. poke with a patch -- use for insulin delivery into diabetic hairless rats
(sol of insulin was placed on top of the micro needle array and left)
2. coat and poke -- used for protein vaccine delivery (microneedles prepared with
dry film coating of antigen and then inserted into skin of hairless guinea pig --
possible allergy treatment?)
3. dip and scrape -- used for DNA delivery (arrays dipped into a solution of DNA
and scraped multiple times across the skin of mice to create micro abrasions)
which skin layer can be reached using nano-needles?
Ans: can only reach the upper layer of the epidermis because they are too small
to penetrate the stratum corneum
© 2025/ 2026 | ® All rights reserved
, 2 | Page
what are the main applications of nano-needles
Ans: drug delivery without nanoparticles and manipulation of organelles
describe and understand how it works the nano-valve designed by Zink et al
Ans: - a nano-valve that can be opened and closed (trap and release molecules0
-- could be used for drug delivery such as insulin release
how it works:
1. guest molecule is loaded into the pores (by diffusion)
2. valve is closed bc of oxidation of TTF
3. valve is opened by adding ascorbic acid to reduce TTF (position of CBPQT4
ring changes)
4. release of the guest molecule
what is nano-endoscopy as defined by Zhang et al
Ans: - single cell endoscopy: probes accurately inserted into a live cell (allows
for intracellular analysis)
- Zhang et al fabricated a nano device -- assembled single nanoporus gold
nanowire on the tip of a tungsten needle (+ NP to sense different cell types)
- sensing biomarkers for disease and able to eliminate damaged cells at an early
state
what are the advantages of performing nano coating on surgical blades?
© 2025/ 2026 | ® All rights reserved
nanomedicine test 3 Questions and Correct Answers/
Latest Update / Already Graded
difference between nano devices and nanoparticles
Ans: - nano devices: they are made of nanoparticles (usually with different
composition -- ex. microneedles and nano needles, and nano-valves for drug
delivery)
- nanoparticles: particle of any shape with dimensions in the 1 x 10 ^-9 - 1x10 ^-7
(1-100nm)
why did we study micro-needles if they are not a nano object?
Ans: because they are still relevant in the field of medicine. Microneedles permit
transport of macromolecules, as well as possibly supramolecular complexes and
Microparticles
which skin layer can be reached using micro-needles?
Ans: stratum corneum
describe the three transdermal drug delivery methods using micro-needles
Ans: 1. poke with a patch -- use for insulin delivery into diabetic hairless rats
(sol of insulin was placed on top of the micro needle array and left)
2. coat and poke -- used for protein vaccine delivery (microneedles prepared with
dry film coating of antigen and then inserted into skin of hairless guinea pig --
possible allergy treatment?)
3. dip and scrape -- used for DNA delivery (arrays dipped into a solution of DNA
and scraped multiple times across the skin of mice to create micro abrasions)
which skin layer can be reached using nano-needles?
Ans: can only reach the upper layer of the epidermis because they are too small
to penetrate the stratum corneum
© 2025/ 2026 | ® All rights reserved
, 2 | Page
what are the main applications of nano-needles
Ans: drug delivery without nanoparticles and manipulation of organelles
describe and understand how it works the nano-valve designed by Zink et al
Ans: - a nano-valve that can be opened and closed (trap and release molecules0
-- could be used for drug delivery such as insulin release
how it works:
1. guest molecule is loaded into the pores (by diffusion)
2. valve is closed bc of oxidation of TTF
3. valve is opened by adding ascorbic acid to reduce TTF (position of CBPQT4
ring changes)
4. release of the guest molecule
what is nano-endoscopy as defined by Zhang et al
Ans: - single cell endoscopy: probes accurately inserted into a live cell (allows
for intracellular analysis)
- Zhang et al fabricated a nano device -- assembled single nanoporus gold
nanowire on the tip of a tungsten needle (+ NP to sense different cell types)
- sensing biomarkers for disease and able to eliminate damaged cells at an early
state
what are the advantages of performing nano coating on surgical blades?
© 2025/ 2026 | ® All rights reserved
