HEMATOLOGY EXAM 1 UAMS
QUESTIONS WITH CORRECT ANSWERS
Anticoagulants - Correct Answers -EDTA (most common), heparin, sodium citrate
Types of Normal Blood Cells Found in Peripheral Blood - Correct Answers -• Red Blood
Cells
Platelets
White Blood Cells
Lymphocyte
Monocyte
(Granulocytes)
Eosinophil
Basophil (baso)
Segmented neutrophil
• Band neutrophil
"cyte" - Correct Answers -cell
Intramedullary hemolysis - Correct Answers -within bone marrow cell break-up
Extramedullary hemolysis - Correct Answers -outside bone marrow cell lysis
- Cell destruction outside the bone marrow - Correct Answers -Extramedullary
hemolysis
Erythroid hyperplasia - Correct Answers -increased red cell formation
Lymphopenia - Correct Answers -decreased number of lymphs
Eosinophilia - Correct Answers -increased number of eos
Erythrocyte Replacement - Correct Answers -Approximately 1% of the total red cells are
removed from circulation on a daily basis
These red cells are replaced by approximately 1% - Correct Answers -approximately
1% of the younger RBCS reticulocytes from the bone marrow pool
,Erythropoiesis is dependent upon - Correct Answers -cytokine stimulation
Erythropoietin in the kidney Approximately - Correct Answers -1% of RBCS are
produced daily
Polycythemia - Correct Answers -All cells in the blood are increased many cells
increased
Intravascular Hemolysis - Correct Answers -inside vessel breakdown of RBCS
CBC includes - Correct Answers -WBC, RBC, platelet count, hemoglobin (hgb),
hematocrit (hct) Indices
• MCV • - Correct Answers -mean cell volume indicates RBC size
• MCH - Correct Answers -mean cell hemoglobin - weight of hemoglobin contained in
RBC
• MCHC - Correct Answers -mean cell hemoglobin content - average concentration of
hemoglobin in RBC
• MCH, MCHC decreased in - Correct Answers -microcytic anemia,
• MCH, MCHC increased - Correct Answers -macrocytic anemia
• One of the largest organs in the body - Correct Answers -Bone Marrow
Bone Marrow Defined as - Correct Answers -tissue located within the cavities of the
cortical bones
Bone Marrow Cavities consist of - Correct Answers -trabecular bone resembling a
honeycomb-like structure
• More than 100 times blood cells in your ———- than there are people in the world! -
Correct Answers -Bone Marrow
Bone marrow is located within - Correct Answers -within the cavities of the cortical
bones
Bone Marrow two types - Correct Answers -Red marrow Yellow marrow
Red marrow - Correct Answers -hematopoietically active marrow Produces cells
Yellow marrow - Correct Answers -hematopoietically inactive marrow composed
primarily of adipocytes (fat cells)
,Can return to active under right contions (example hemolysis) - Correct Answers -
Yellow marrow
• Not all bones contain - Correct Answers -bone marrow
During infancy and early childhood, bone marrow - Correct Answers -is mostly red
active marrow in all bones
Sites of hematopoiesis decreases - Correct Answers -during fetal development
Bone Marrow Retrogression occurs - Correct Answers -beginning at age 5-7
- Red marrow is restricted to - Correct Answers -flat bones, sternum, vertebrae, pelvis,
ribs, skull and proximal long bones
• By adulthood, marrow is - Correct Answers -50% blood cells and 50% fat
Blood & nutrients are supplied by the - Correct Answers -periosteal arteries that coil
around the central vein, passing along the bone canal
sinuses - Correct Answers -• Sinus is a venous vessel found in the RES that is larger
than a capillary but smaller than a vein
Sinuses hook up to - Correct Answers -larger veins and return into main circulation
Bone Marrow Blood Flow - Correct Answers -Blood & nutrients are supplied by the
periosteal arteries that coil around the central vein, passing along the bone canal -
Branches and forms capillaries then sinuses
Red Marrow Composed of - Correct Answers -extravascular cords that contain all of the
developing blood cell lineages, stem and progenitor cells, adventitial cells, and
macrophages
Composed of extravascular cords - Correct Answers -Red Marrow
Red Marrow - Cells are in - Correct Answers -semi-liquid cords or wedges between
sinuses supported by trabeculae of spongy bone and reticular adventitial cells Cells
develop in specific niches within the cords
Trabeculae - Correct Answers -calcified bone
Location of Cell Development RBCS - Correct Answers -develop in small clusters
adjacent to the outer surfaces of the vascular sinuses
, Location of Cell Development Megakaryocytes - Correct Answers -develop close to the
vascular walls
Location of Cell Development Granulocytes - Correct Answers -develop deep in the
cord and migrate closer to the vascular sinuses
• RBC precursors will also surround - Correct Answers -macrophages carrying iron to
incorporate iron into hemoglobin
Cells mature and - Correct Answers -between layers of reticular adventitial cells that
form a discontinuous layer along the sinus
Adjacent to the layer of adventitial cells is a - Correct Answers -basement membrane
followed by a continuous layer of endothelial cells
Adventitial cells... - Correct Answers -contract allowing mature blood cells to pass
through pores of the endothelial cytoplasm and into circulation
• Cells travel through the - Correct Answers -venous system
maintain steady state - Correct Answers -Supply of cells
Cellular needs will be supplied by - Correct Answers -bone marrow
Yellow lymph has the capability to convert - Correct Answers -to red marroW
Yellow lymph has the capability to convert to - Correct Answers -red marroW Increased
Demand - Hemolysis - Excessive blood loss
• Bean shaped structures that occur in groups or chains at various intervals - Correct
Answers -Lymph Nodes
Lymph Nodes - Correct Answers -• Bean shaped structures that occur in groups or
chains at various intervals among the lymphatic system - Runs parallel to but NOT part
of the circulatory system
Runs parallel to but NOT part of the circulatory system - Correct Answers -Lymph
Nodes
Does not contain RBCS - Correct Answers -Lymph Nodes
Lymph Nodes contain - Correct Answers -• Encapsulated collection of lymphocytes,
plasma cells, and macrophages
Cells in Lymph Node are organized... - Correct Answers -• Cells are organized by
trabeculae (fibrous connective tissue) that extend into cellular areas
QUESTIONS WITH CORRECT ANSWERS
Anticoagulants - Correct Answers -EDTA (most common), heparin, sodium citrate
Types of Normal Blood Cells Found in Peripheral Blood - Correct Answers -• Red Blood
Cells
Platelets
White Blood Cells
Lymphocyte
Monocyte
(Granulocytes)
Eosinophil
Basophil (baso)
Segmented neutrophil
• Band neutrophil
"cyte" - Correct Answers -cell
Intramedullary hemolysis - Correct Answers -within bone marrow cell break-up
Extramedullary hemolysis - Correct Answers -outside bone marrow cell lysis
- Cell destruction outside the bone marrow - Correct Answers -Extramedullary
hemolysis
Erythroid hyperplasia - Correct Answers -increased red cell formation
Lymphopenia - Correct Answers -decreased number of lymphs
Eosinophilia - Correct Answers -increased number of eos
Erythrocyte Replacement - Correct Answers -Approximately 1% of the total red cells are
removed from circulation on a daily basis
These red cells are replaced by approximately 1% - Correct Answers -approximately
1% of the younger RBCS reticulocytes from the bone marrow pool
,Erythropoiesis is dependent upon - Correct Answers -cytokine stimulation
Erythropoietin in the kidney Approximately - Correct Answers -1% of RBCS are
produced daily
Polycythemia - Correct Answers -All cells in the blood are increased many cells
increased
Intravascular Hemolysis - Correct Answers -inside vessel breakdown of RBCS
CBC includes - Correct Answers -WBC, RBC, platelet count, hemoglobin (hgb),
hematocrit (hct) Indices
• MCV • - Correct Answers -mean cell volume indicates RBC size
• MCH - Correct Answers -mean cell hemoglobin - weight of hemoglobin contained in
RBC
• MCHC - Correct Answers -mean cell hemoglobin content - average concentration of
hemoglobin in RBC
• MCH, MCHC decreased in - Correct Answers -microcytic anemia,
• MCH, MCHC increased - Correct Answers -macrocytic anemia
• One of the largest organs in the body - Correct Answers -Bone Marrow
Bone Marrow Defined as - Correct Answers -tissue located within the cavities of the
cortical bones
Bone Marrow Cavities consist of - Correct Answers -trabecular bone resembling a
honeycomb-like structure
• More than 100 times blood cells in your ———- than there are people in the world! -
Correct Answers -Bone Marrow
Bone marrow is located within - Correct Answers -within the cavities of the cortical
bones
Bone Marrow two types - Correct Answers -Red marrow Yellow marrow
Red marrow - Correct Answers -hematopoietically active marrow Produces cells
Yellow marrow - Correct Answers -hematopoietically inactive marrow composed
primarily of adipocytes (fat cells)
,Can return to active under right contions (example hemolysis) - Correct Answers -
Yellow marrow
• Not all bones contain - Correct Answers -bone marrow
During infancy and early childhood, bone marrow - Correct Answers -is mostly red
active marrow in all bones
Sites of hematopoiesis decreases - Correct Answers -during fetal development
Bone Marrow Retrogression occurs - Correct Answers -beginning at age 5-7
- Red marrow is restricted to - Correct Answers -flat bones, sternum, vertebrae, pelvis,
ribs, skull and proximal long bones
• By adulthood, marrow is - Correct Answers -50% blood cells and 50% fat
Blood & nutrients are supplied by the - Correct Answers -periosteal arteries that coil
around the central vein, passing along the bone canal
sinuses - Correct Answers -• Sinus is a venous vessel found in the RES that is larger
than a capillary but smaller than a vein
Sinuses hook up to - Correct Answers -larger veins and return into main circulation
Bone Marrow Blood Flow - Correct Answers -Blood & nutrients are supplied by the
periosteal arteries that coil around the central vein, passing along the bone canal -
Branches and forms capillaries then sinuses
Red Marrow Composed of - Correct Answers -extravascular cords that contain all of the
developing blood cell lineages, stem and progenitor cells, adventitial cells, and
macrophages
Composed of extravascular cords - Correct Answers -Red Marrow
Red Marrow - Cells are in - Correct Answers -semi-liquid cords or wedges between
sinuses supported by trabeculae of spongy bone and reticular adventitial cells Cells
develop in specific niches within the cords
Trabeculae - Correct Answers -calcified bone
Location of Cell Development RBCS - Correct Answers -develop in small clusters
adjacent to the outer surfaces of the vascular sinuses
, Location of Cell Development Megakaryocytes - Correct Answers -develop close to the
vascular walls
Location of Cell Development Granulocytes - Correct Answers -develop deep in the
cord and migrate closer to the vascular sinuses
• RBC precursors will also surround - Correct Answers -macrophages carrying iron to
incorporate iron into hemoglobin
Cells mature and - Correct Answers -between layers of reticular adventitial cells that
form a discontinuous layer along the sinus
Adjacent to the layer of adventitial cells is a - Correct Answers -basement membrane
followed by a continuous layer of endothelial cells
Adventitial cells... - Correct Answers -contract allowing mature blood cells to pass
through pores of the endothelial cytoplasm and into circulation
• Cells travel through the - Correct Answers -venous system
maintain steady state - Correct Answers -Supply of cells
Cellular needs will be supplied by - Correct Answers -bone marrow
Yellow lymph has the capability to convert - Correct Answers -to red marroW
Yellow lymph has the capability to convert to - Correct Answers -red marroW Increased
Demand - Hemolysis - Excessive blood loss
• Bean shaped structures that occur in groups or chains at various intervals - Correct
Answers -Lymph Nodes
Lymph Nodes - Correct Answers -• Bean shaped structures that occur in groups or
chains at various intervals among the lymphatic system - Runs parallel to but NOT part
of the circulatory system
Runs parallel to but NOT part of the circulatory system - Correct Answers -Lymph
Nodes
Does not contain RBCS - Correct Answers -Lymph Nodes
Lymph Nodes contain - Correct Answers -• Encapsulated collection of lymphocytes,
plasma cells, and macrophages
Cells in Lymph Node are organized... - Correct Answers -• Cells are organized by
trabeculae (fibrous connective tissue) that extend into cellular areas
