Page |1
WALDEN 6630 PSYCHOPHARMACOLOGY
MIDTERM STUDY GUIDE |ACTUAL EXAM WITH
100% VERIFIED QUESTIONS AND CORRECT
ANSWERS| EXCELLENT SCORES
Serotonin regulates - Correct-answer-Mood, emotion, feeding, and
reproductive behavior
This class of antidepressants binds to presynaptic SERT and inhibits
them from reuptake of serotonin to increase levels in the synaptic cleft
to bind with postsysnaptic 5HT2 receptors - Correct-answer-SSRIs
First line therapy for MDD due to milder side effect profiles - Correct-
answer-SSRIs
Six Common SSRIs - Correct-answer-citalopram, escitalopram,
fluoxetine, fluvoxamine, sertraline, paroxetine
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Onset of therapeutic benefit from SSRIs - Correct-answer-4-6 weeks
In addition to MDD, SSRIs also treat - Correct-answer-Chronic Anxiety,
PTSD, OCD, and eating disorders (bulimia)
Five Common side effects of SSRIs include - Correct-answer-Anxiety,
insomnia, GI distress, sexual dysfunction (ED), SIADH
Severe side effect of SSRIs in children/adolescents under age 25 years
old - Correct-answer-suicidal ideation
Life threatening adverse effect of SSRIs, especially when used in
combination with other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) -
Correct-answer-Serotonin Syndrome
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Excess accumulation of serotonin resulting in overstimulation of the
nervous system - Correct-answer-Serotonin Syndrome
Seven symptoms of Serotonin Syndrome - Correct-answer-Flushing,
hyperthermia, agitation, muscle rigidity, seizure, coma, HYPERreflexia
This class of antidepressants is especially cardiotoxic and may cause
arrhythmias and prolonged QT interval: - Correct-answer-TCAs
Treatment of cardiotoxicity from TCAs: - Correct-answer-Sodium
Bicarbonate
The three most common causes of death from TCAs (The 3C's): -
Correct-answer-Convulsion, Coma, and Cardiotoxicity
This class of antidepressants inhibits Cytochrome P450 Enzymes: -
Correct-answer-TCAs
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Combining these substances with Cytochrome P450 enzyme inhibitors
can result in severe respiratory depression and death due to toxic
levels: - Correct-answer-Ethanol and sedative hypnotics (benzos)
These two neuron types have abundant Alpha 2 receptors: - Correct-
answer-Noradrenergic and Serotonergic
When stimulated Alpha 2 receptors inhibit the activity of the
presynaptic neuron and decrease the release of these two
neurotransmitters: - Correct-answer-Norepinephrine and Serotonin
Six common Atypical Antidepressants used for individuals that did not
respond to other antidepressants: - Correct-answer-mirtazapine,
trazadone, nefazodone, vilazodone, vortioxetine, bupropion
This antidepressant effects Alpha 2 receptors, 5-HT2A receptors, 5-
HT3A receptors, and Histamine H1 receptors: - Correct-answer-
mirtazapine
WALDEN 6630 PSYCHOPHARMACOLOGY
MIDTERM STUDY GUIDE |ACTUAL EXAM WITH
100% VERIFIED QUESTIONS AND CORRECT
ANSWERS| EXCELLENT SCORES
Serotonin regulates - Correct-answer-Mood, emotion, feeding, and
reproductive behavior
This class of antidepressants binds to presynaptic SERT and inhibits
them from reuptake of serotonin to increase levels in the synaptic cleft
to bind with postsysnaptic 5HT2 receptors - Correct-answer-SSRIs
First line therapy for MDD due to milder side effect profiles - Correct-
answer-SSRIs
Six Common SSRIs - Correct-answer-citalopram, escitalopram,
fluoxetine, fluvoxamine, sertraline, paroxetine
, Page |2
Onset of therapeutic benefit from SSRIs - Correct-answer-4-6 weeks
In addition to MDD, SSRIs also treat - Correct-answer-Chronic Anxiety,
PTSD, OCD, and eating disorders (bulimia)
Five Common side effects of SSRIs include - Correct-answer-Anxiety,
insomnia, GI distress, sexual dysfunction (ED), SIADH
Severe side effect of SSRIs in children/adolescents under age 25 years
old - Correct-answer-suicidal ideation
Life threatening adverse effect of SSRIs, especially when used in
combination with other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.) -
Correct-answer-Serotonin Syndrome
, Page |3
Excess accumulation of serotonin resulting in overstimulation of the
nervous system - Correct-answer-Serotonin Syndrome
Seven symptoms of Serotonin Syndrome - Correct-answer-Flushing,
hyperthermia, agitation, muscle rigidity, seizure, coma, HYPERreflexia
This class of antidepressants is especially cardiotoxic and may cause
arrhythmias and prolonged QT interval: - Correct-answer-TCAs
Treatment of cardiotoxicity from TCAs: - Correct-answer-Sodium
Bicarbonate
The three most common causes of death from TCAs (The 3C's): -
Correct-answer-Convulsion, Coma, and Cardiotoxicity
This class of antidepressants inhibits Cytochrome P450 Enzymes: -
Correct-answer-TCAs
, Page |4
Combining these substances with Cytochrome P450 enzyme inhibitors
can result in severe respiratory depression and death due to toxic
levels: - Correct-answer-Ethanol and sedative hypnotics (benzos)
These two neuron types have abundant Alpha 2 receptors: - Correct-
answer-Noradrenergic and Serotonergic
When stimulated Alpha 2 receptors inhibit the activity of the
presynaptic neuron and decrease the release of these two
neurotransmitters: - Correct-answer-Norepinephrine and Serotonin
Six common Atypical Antidepressants used for individuals that did not
respond to other antidepressants: - Correct-answer-mirtazapine,
trazadone, nefazodone, vilazodone, vortioxetine, bupropion
This antidepressant effects Alpha 2 receptors, 5-HT2A receptors, 5-
HT3A receptors, and Histamine H1 receptors: - Correct-answer-
mirtazapine
