2025 ABGC Practice Exam Questions With Correct Detailed Answers.

A 45-year-old patient with colon cancer comes for genetic counseling. In conjunction with microsatellite instability testing, which of the following is the BEST next step in deciding if the tumor is the result of Lynch syndrome? a. BRAF mutation testing b. immunohistochemical testing c. methylation testing d. KRAS mutation testing - Answer Immunohistochemical testing Which of the following issues is MOST important to discuss with a parent regarding testing their minor child for a familial MSH2 pathogenic variant? a. justice b. beneficence c. nonmaleficence d. autonomy - Answer Autonomy Before disclosing test results to an adult patient by phone, a genetic counselor should FIRST? a. determine if a support person is present b. confirm the genetic counselor is speaking to the patient c. re-assess understanding of possible test results d. re-establish rapport by making small talk - Answer Confirm the genetic counselor is speaking to the patient A couple seeks counseling because their first child was born with a ventricular septal defect. There is no family history of any congenital heart disease, and the parents have normal cardiac examinations. They should be counseled that the risk that a subsequent child will have a similar or other cardiac defect is closest to? a. 8-10% b. 25% c. less than 1% d. 3-5% - Answer 3-5% Exome sequencing is performed for a child with microcephaly, atrial septal defect, intellectual disability, and gross motor delay. A pathogenic variant is identified in a gene associated with Brugada syndrome. The BEST interpretation of this finding is that it is?