GMS 6474: PROBLEM SETS EXAM WITH
COMPLETE SOLUTIONS
During contraction muscle fibers fatigue at different rates. Type 1 fibers fatigue ______
due to their ______ oxidative capacity.
last, low
last, high
first, low
first, high - ANSlast, high
The motor neuron releases this neurotransmitter into the post-synaptic cleft of the
neuromuscular junction to invoke an end-plate potential.
Acetylcholine
Potassium
Nicotine
Calcium - ANSAcetylcholine
What is the role of Titan within muscle?
It allows for the rapid depolarization of the muscle cell
It slows the electrical conduction through muscle cells
It tethers myosin filaments to the Z-line
It binds collagen. filaments to the M line
It sequesters Ca++ within the muscle cell - ANSIt tethers myosin filaments to the Z-line
In skeletal muscle, when there is maximal load, the velocity of contraction equals 0. This
is considered what type of contraction?
Isotonic
Isometric
Lengthening
Shortening - ANSIsometric
, Duchenne Muscular Dystrophy (DMD) is characterized by the complete loss of which of
the following muscle proteins?
Dystrophin
Actin
Myosin
Nebulin
Serca - ANSDystrophin
With respect to muscle physiology, after binding, the myosin pulls on actin towards the
M line and supersedes it. This causes the release of Pi as filaments are pulled together
and move towards the H zone, which results in contraction of the muscle. Which of the
following best describes this step of contraction?
Dissociation
Activation
Termination
Power Stoke
Binding - ANSPower Stoke
Cardiac muscle acts as a syncytium due to the presence of ________ and _________
found in Intercalated Disks
Desmosomes, gap junctions
mitochondria, dyad
sarcomeres, dyad
t-tubules, sarcoplasmic reticulum - ANSDesmosomes, gap junctions
What do smooth muscle fibers lack?
Tropmyosin
Troponins
Actin Filaments
Myosin Filaments - ANSTroponins
Calcium is released and sequestered differently in Skeletal and Cardiac muscles. What
is one physiological relevance of cardiac muscle calcium handling?
Calsequestrin prevents tetany
Large Calcium stores in the SR allows for full contraction once activated
Relies on Calcium Induced
Calcium Release for regulation of contractile strength
COMPLETE SOLUTIONS
During contraction muscle fibers fatigue at different rates. Type 1 fibers fatigue ______
due to their ______ oxidative capacity.
last, low
last, high
first, low
first, high - ANSlast, high
The motor neuron releases this neurotransmitter into the post-synaptic cleft of the
neuromuscular junction to invoke an end-plate potential.
Acetylcholine
Potassium
Nicotine
Calcium - ANSAcetylcholine
What is the role of Titan within muscle?
It allows for the rapid depolarization of the muscle cell
It slows the electrical conduction through muscle cells
It tethers myosin filaments to the Z-line
It binds collagen. filaments to the M line
It sequesters Ca++ within the muscle cell - ANSIt tethers myosin filaments to the Z-line
In skeletal muscle, when there is maximal load, the velocity of contraction equals 0. This
is considered what type of contraction?
Isotonic
Isometric
Lengthening
Shortening - ANSIsometric
, Duchenne Muscular Dystrophy (DMD) is characterized by the complete loss of which of
the following muscle proteins?
Dystrophin
Actin
Myosin
Nebulin
Serca - ANSDystrophin
With respect to muscle physiology, after binding, the myosin pulls on actin towards the
M line and supersedes it. This causes the release of Pi as filaments are pulled together
and move towards the H zone, which results in contraction of the muscle. Which of the
following best describes this step of contraction?
Dissociation
Activation
Termination
Power Stoke
Binding - ANSPower Stoke
Cardiac muscle acts as a syncytium due to the presence of ________ and _________
found in Intercalated Disks
Desmosomes, gap junctions
mitochondria, dyad
sarcomeres, dyad
t-tubules, sarcoplasmic reticulum - ANSDesmosomes, gap junctions
What do smooth muscle fibers lack?
Tropmyosin
Troponins
Actin Filaments
Myosin Filaments - ANSTroponins
Calcium is released and sequestered differently in Skeletal and Cardiac muscles. What
is one physiological relevance of cardiac muscle calcium handling?
Calsequestrin prevents tetany
Large Calcium stores in the SR allows for full contraction once activated
Relies on Calcium Induced
Calcium Release for regulation of contractile strength
